INT181636

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 4.46
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (BMP1) peptidase activity (BMP1) extracellular space (BMP1)
small molecule metabolic process (BMP1) extracellular region (BMP1) lipid metabolic process (BMP1)
Anatomy Link Frequency
urine 6
adipose tissue 2
BMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dextromethorphan 4 99.16 Very High Very High Very High
withdrawal 4 88.80 High High
cocaine 8 86.04 High High
alcohol 9 80.16 Quite High
gABA 1 64.64 Quite High
Onset of action 4 64.28 Quite High
Glutamate receptor 1 58.56 Quite High
headache 3 55.76 Quite High
Migraine 5 54.60 Quite High
Pain 3 49.12 Quite Low
Disease Link Frequency Relevance Heat
Poisoning 84 99.96 Very High Very High Very High
Obesity 4 95.60 Very High Very High Very High
Schizophrenia 24 94.16 High High
Overdose 8 85.60 High High
Neuroleptic Malignant Syndrome 4 83.44 Quite High
Thyroid Crisis 4 82.00 Quite High
Viral Meningitis 4 81.40 Quite High
Meningitis 4 80.72 Quite High
Sepsis 4 80.24 Quite High
Hyponatremia 4 79.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, a qualitative urine toxicologic screen has become mandatory standard of care for any patient, infant or adult, with altered mental status of unknown etiology.13 Although earlier literature describes three dose-related stages of PCP intoxication, quantitative PCP levels do not correlate well with clinical findings and thus should not guide clinical management.1, 6, 13, 20, 22
Positive_regulation (quantitative) of Gene_expression (levels) of PCP in urine associated with poisoning
1) Confidence 0.44 Published 2007 Journal The California Journal of Emergency Medicine Section Body Doc Link PMC2859735 Disease Relevance 1.75 Pain Relevance 0.12
Several drugs like diphenhydramine, dextromethorphan, and venlafaxine and its derivatives may cause a urine specimen to test positive for PCP if tests other than gas chromatography/mass spectrophotometry (GS/MS) are used, such as the fluorescence polarization immunoassay or high pressure liquid chromatography.35, 36
Spec (may) Positive_regulation (cause) of Gene_expression (test) of PCP in urine associated with dextromethorphan
2) Confidence 0.38 Published 2007 Journal The California Journal of Emergency Medicine Section Body Doc Link PMC2859735 Disease Relevance 0.95 Pain Relevance 0.11
Several drugs like diphenhydramine, dextromethorphan, and venlafaxine and its derivatives may cause a urine specimen to test positive for PCP if tests other than gas chromatography/mass spectrophotometry (GS/MS) are used, such as the fluorescence polarization immunoassay or high pressure liquid chromatography.35, 36
Positive_regulation (positive) of Gene_expression (test) of PCP in urine associated with dextromethorphan
3) Confidence 0.38 Published 2007 Journal The California Journal of Emergency Medicine Section Body Doc Link PMC2859735 Disease Relevance 0.93 Pain Relevance 0.11
In animal experiments PCP-binding antibodies actually increased serum concentrations of PCP, indicating that they simply alter its distribution.16 PCP levels are highest in adipose tissue, and because of its slow, uneven release from lipid stores, the half-life of PCP is believed to be three days.3, 13 Due to the brain’s high lipid content and ion trapping, cerebral levels of PCP may be nine times serum levels, allowing its CNS effects to last from seven hours to as long as seven days in chronic users.17
Positive_regulation (increased) of Gene_expression (antibodies) of PCP-binding in adipose tissue associated with obesity
4) Confidence 0.38 Published 2007 Journal The California Journal of Emergency Medicine Section Body Doc Link PMC2859735 Disease Relevance 0.33 Pain Relevance 0.11
Since PCP as well exerts
Positive_regulation (Since) of Gene_expression (exerts) of PCP
5) Confidence 0.03 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.50 Pain Relevance 0.22

General Comments

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