INT181639

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.72
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (NOS3) aging (NOS3) Golgi apparatus (NOS3)
mitochondrion organization (NOS3) cytoplasm (NOS3) cytosol (NOS3)
Anatomy Link Frequency
nerve 2
NOS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 95 99.44 Very High Very High Very High
bradykinin 12 94.80 High High
Inflammation 77 94.24 High High
ischemia 24 93.92 High High
cINOD 66 89.32 High High
COX-2 inhibitor 7 88.40 High High
cytokine 26 87.60 High High
antagonist 12 81.20 Quite High
b2 receptor 1 77.76 Quite High
Inflammatory mediators 5 73.44 Quite High
Disease Link Frequency Relevance Heat
Stress 35 99.98 Very High Very High Very High
Reperfusion Injury 14 94.68 High High
INFLAMMATION 93 94.24 High High
Atherosclerosis 11 94.08 High High
Cv Unclassified Under Development 37 93.92 High High
Increased Venous Pressure Under Development 163 93.40 High High
Diabetes Mellitus 22 91.24 High High
Targeted Disruption 6 89.84 High High
Stroke 4 88.84 High High
Cardiovascular Disease 14 86.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In animal models, steady laminar shear stress induces the upregulation of both eNOS and COX-2 [37].
Positive_regulation (induces) of Positive_regulation (upregulation) of eNOS associated with stress
1) Confidence 0.41 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582806 Disease Relevance 0.49 Pain Relevance 0.54
Formation of NO could also occur after receptor stimulated activation of constitutive NOS (cNOS) or activation of neuronal NOS (nNOS) in nerve endings.
Positive_regulation (stimulated) of Positive_regulation (activation) of cNOS in nerve
2) Confidence 0.38 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1693561 Disease Relevance 0.50 Pain Relevance 0.29
These medications are thought to produce a local effect through upregulation and activation of eNOS to increase NO production (Tseng et al 2005).
Neg (NO) Positive_regulation (increase) of Positive_regulation (activation) of eNOS
3) Confidence 0.35 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 1.47 Pain Relevance 0.18
The main tools available to study NOS-dependent effects in humans in vivo have until recently been the nonselective NOS inhibitor l-NMMA and agonists such as acetylcholine that induce eNOS activation.
Positive_regulation (induce) of Positive_regulation (activation) of eNOS associated with agonist
4) Confidence 0.34 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.53 Pain Relevance 0.08
The activation of eNOS is induced by increase in
Positive_regulation (induced) of Positive_regulation (activation) of eNOS
5) Confidence 0.25 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.24 Pain Relevance 0.15
NO regulation and synthesis via activation of the Ca2+ dependent eNOS or nNOS isozymes can occur in response to a diverse array of agonists that signal through GPCRs, including the widely documented bradykinin and muscarinic acetylcholine receptors signalling pathways, in addition to TP [70,80].
Positive_regulation (activation) of Positive_regulation (dependent) of eNOS associated with agonist and bradykinin
6) Confidence 0.20 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.17
Another study has revealed that eNOS upregulation induced by RGZ may
Positive_regulation (induced) of Positive_regulation (upregulation) of eNOS
7) Confidence 0.19 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 0.35 Pain Relevance 0
Pathological increases in cellular NO levels due to an increase in iNOS expression or overactivation of eNOS and nNOS result in the formation of peroxynitrite (ONOO-) radical [67].
Positive_regulation (increase) of Positive_regulation (overactivation) of eNOS
8) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 0.13 Pain Relevance 0

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