INT181650

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Context Info
Confidence 0.77
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 23
Total Number 27
Disease Relevance 13.66
Pain Relevance 5.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Glud1) oxidoreductase activity (Glud1) enzyme binding (Glud1)
cellular amino acid metabolic process (Glud1) cytoplasm (Glud1)
Anatomy Link Frequency
neurons 11
brain 4
neuronal 2
hippocampus 1
Glud1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 2838 100.00 Very High Very High Very High
Hippocampus 553 99.44 Very High Very High Very High
chemokine 207 85.84 High High
Central nervous system 161 85.44 High High
anesthesia 26 76.96 Quite High
Inflammation 92 76.16 Quite High
ketamine 3 76.00 Quite High
Neurotransmitter 139 63.92 Quite High
Dopamine 23 61.28 Quite High
Pyramidal cell 23 53.84 Quite High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 276 99.44 Very High Very High Very High
Targeted Disruption 1794 99.26 Very High Very High Very High
Aging 276 98.82 Very High Very High Very High
Injury 184 97.88 Very High Very High Very High
Lifespan 138 96.28 Very High Very High Very High
Disease 302 93.96 High High
Stress 557 83.88 Quite High
Death 297 82.92 Quite High
Nervous System Malformation 184 76.44 Quite High
INFLAMMATION 161 76.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The genes whose expression would be significantly altered in Glud1 mice compared with age-matched wild type (wt) animals, and the molecular pathways and cellular functions that they represent, may help unravel the most substantial neuronal responses to the over-expression of Glud1 and the exposure of cells to excess Glu stimulation.
Gene_expression (expression) of Glud1 in neuronal associated with glutamate
1) Confidence 0.77 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.50 Pain Relevance 0.29
This observation supported the idea that neurons and glia in the brains of the Glud1 Tg mice were responding to the chronic over-expression of Glud1 in neurons by exhibiting a different pattern of DNA transcription than that seen in wt mice.
Gene_expression (expression) of Glud1 in neurons associated with targeted disruption
2) Confidence 0.77 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.78 Pain Relevance 0.11
GDH (cytosolic marker), CZ (lysosomal marker) and CRT (ER marker) were detected in the soluble fractions by Western blot using the appropriate antibodies.


Gene_expression (detected) of GDH
3) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
In addition to the increases in Glu release, the Glud1 mice may also be exposed to altered intracellular metabolic states as a result of the over-expression of the mitochondrial enzyme GLUD1.
Gene_expression (expression) of GLUD1 associated with glutamate
4) Confidence 0.67 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.54 Pain Relevance 0.30
Yet, despite the loss of labelling by MAP2A, PTK2B labelling appeared to be well preserved in the dendrites of neurons from the Glud1 mice as revealed by the lack of significant differences in the same fields of the stratum radiatum of the CA1 region from the same sections of Glud1 and wt mouse hippocampus as those analyzed for MAP2A labelling (PTK2B = 43.72 ± 4.21, for Glud1; 41.32 ± .03, for wt; n = 3 Tg and 3 wt mice; P = 0.69, ANOVA).
Gene_expression (sections) of Glud1 in hippocampus associated with targeted disruption and hippocampus
5) Confidence 0.67 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.23 Pain Relevance 0.19
This observation supported the idea that neurons and glia in the brains of the Glud1 Tg mice were responding to the chronic over-expression of Glud1 in neurons by exhibiting a different pattern of DNA transcription than that seen in wt mice.
Gene_expression (over) of Glud1 in neurons associated with targeted disruption
6) Confidence 0.60 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.78 Pain Relevance 0.11
The present study has focused on the molecular pathways that may be affected by the over-expression of Glud1 in neurons in young adult mice.
Gene_expression (-) of Glud1 in neurons
7) Confidence 0.60 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.86 Pain Relevance 0.13
Thus, it appeared that hippocampal neurons responded to excess expression of Glud1 and activation of Glu neurotransmission by up-regulating several genes related to vesicular trafficking, genes that are also part of the Huntington's disease pathway.


Gene_expression (expression) of Glud1 in neurons associated with glutamate and disease
8) Confidence 0.60 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.71 Pain Relevance 0.14
The present study has focused on the molecular pathways that may be affected by the over-expression of Glud1 in neurons in young adult mice.
Gene_expression (expression) of Glud1 in neurons
9) Confidence 0.60 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.86 Pain Relevance 0.13
The present study has focused on the molecular pathways that may be affected by the over-expression of Glud1 in neurons in young adult mice.
Gene_expression (over) of Glud1 in neurons
10) Confidence 0.60 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.86 Pain Relevance 0.13
Transcriptomic changes in neurobiological processes, functions, and pathways in response to Glud1 over-expression
Gene_expression (expression) of Glud1
11) Confidence 0.60 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.30 Pain Relevance 0.05
To achieve excess Glu formation in neurons and increased release from synaptic terminals in these animals, the gene for the enzyme glutamate dehydrogenase 1 (Glud1) was introduced under the control of the promoter for neuron-specific enolase (Nse), thus its over-expression occurs only in neurons [14].
Gene_expression (expression) of glutamate dehydrogenase 1 in neurons associated with glutamate
12) Confidence 0.60 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.73 Pain Relevance 0.45
Transcriptomic changes in neurobiological processes, functions, and pathways in response to Glud1 over-expression
Gene_expression (over) of Glud1
13) Confidence 0.60 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.30 Pain Relevance 0.05
In our previous studies, we have shown that over-expression of Glud1 and the resultant moderate excess Glu formation and synaptic release, were correlated with neuronal, dendritic spine, and nerve ending losses in select regions of the brains of Tg mice, such as the CA1 region of the hippocampus.
Gene_expression (expression) of Glud1 in brains associated with targeted disruption, glutamate and hippocampus
14) Confidence 0.60 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.36 Pain Relevance 0.32
To achieve excess Glu formation in neurons and increased release from synaptic terminals in these animals, the gene for the enzyme glutamate dehydrogenase 1 (Glud1) was introduced under the control of the promoter for neuron-specific enolase (Nse), thus its over-expression occurs only in neurons [14].
Gene_expression (expression) of Glud1 in neurons associated with glutamate
15) Confidence 0.60 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.72 Pain Relevance 0.43
The genes whose expression would be significantly altered in Glud1 mice compared with age-matched wild type (wt) animals, and the molecular pathways and cellular functions that they represent, may help unravel the most substantial neuronal responses to the over-expression of Glud1 and the exposure of cells to excess Glu stimulation.
Gene_expression (over) of Glud1 in neuronal associated with glutamate
16) Confidence 0.60 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.50 Pain Relevance 0.29
Antibodies anti-glutamate dehydrogenase (GDH), anti-CZ and anti-TcCRT were generated in rabbits from proteins either purified from the parasite (first two) or expressed in E. coli (last one).


Gene_expression (expressed) of GDH associated with glutamate
17) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0.16
Antibodies anti-glutamate dehydrogenase (GDH), anti-CZ and anti-TcCRT were generated in rabbits from proteins either purified from the parasite (first two) or expressed in E. coli (last one).


Gene_expression (expressed) of glutamate dehydrogenase associated with glutamate
18) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0.16
GDH was only detectable in mitochondria and mitochondria treated with Triton X-100.
Gene_expression (detectable) of GDH
19) Confidence 0.58 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 0 Pain Relevance 0.05
In the present study, we present a detailed analysis of genome-wide expression differences between nine month-old Glud1 and wt mice.
Gene_expression (expression) of Glud1
20) Confidence 0.58 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.54 Pain Relevance 0.32

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