INT181665

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.67
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Apaf1) aging (Apaf1) Golgi apparatus (Apaf1)
intracellular (Apaf1) cytoplasm (Apaf1) cytosol (Apaf1)
Anatomy Link Frequency
respiratory 1
Apaf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 1 83.32 Quite High
Glutamate 144 82.60 Quite High
Kinase C 21 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 119 97.60 Very High Very High Very High
Death 78 94.48 High High
Stress 20 75.68 Quite High
Malignant Neoplastic Disease 1 55.92 Quite High
Necrosis 5 47.48 Quite Low
Cancer 1 47.12 Quite Low
Injury 5 35.40 Quite Low
Parkinson's Disease 3 28.40 Quite Low
Hepatotoxicity 14 20.44 Low Low
Body Weight 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the cytosol, Apaf1, procaspase-9 and released cytochrome c from the mitochondria interact to form the apoptosome that drives the activation of caspase-3.
Localization (released) of Apaf1
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.95 Pain Relevance 0
Another recently characterized mechanism for pro-caspase-3 activation involves translocation of the respiratory chain protein, cytochrome c (Apaf-2), from mitochondria to the cytosol during the induction of apoptosis by a variety of different agents in non-neuronal and neuronal cells such as cerebellar granule cells [21,50].
Localization (translocation) of Apaf-2 in respiratory associated with apoptosis
2) Confidence 0.20 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 0.72 Pain Relevance 0.23

General Comments

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