INT181668

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Context Info
Confidence 0.77
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.59
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
Spinal 1
cleavage 1
apoptotic cell 1
nervous systems 1
sperm 1
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 121 100.00 Very High Very High Very High
Glutamate 338 99.66 Very High Very High Very High
Morphine 99 99.36 Very High Very High Very High
Raphe magnus 36 97.32 Very High Very High Very High
Dorsal horn neuron 5 94.96 High High
Glutamate receptor 20 94.12 High High
agonist 12 92.00 High High
Spinal cord 47 91.84 High High
nMDA receptor 6 82.84 Quite High
withdrawal 47 78.96 Quite High
Disease Link Frequency Relevance Heat
Death 138 98.58 Very High Very High Very High
Apoptosis 150 98.36 Very High Very High Very High
Coronary Heart Disease 4 97.96 Very High Very High Very High
Drug Induced Neurotoxicity 16 93.84 High High
Hypertrophy 8 89.68 High High
Targeted Disruption 15 88.36 High High
Cv General 4 Under Development 10 85.52 High High
Adhesions 1 84.96 Quite High
Emphysema 27 76.24 Quite High
Nociception 10 70.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic morphine-induced EPSC increase involves PKC pathway
Protein_catabolism (pathway) of PKC associated with kinase c and morphine
1) Confidence 0.77 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074357 Disease Relevance 0 Pain Relevance 0.86
Spinal activation of PKC increases release of glutamate in vivo [9] and in vitro [12], and formalin-induced release of glutamate is prevented by blockade of PKC [17].
Protein_catabolism (blockade) of PKC in Spinal associated with glutamate and kinase c
2) Confidence 0.74 Published 2006 Journal Mol Pain Section Body Doc Link PMC1482680 Disease Relevance 0 Pain Relevance 1.33
White et al. (2007) while experimenting on intact sea urchin spermatozoa showed PKC, most likely through its cleavage into active catalytic product PKM, was the central signaling mediator associated with maintenance of sperm mobility [26].
Protein_catabolism (cleavage) of PKC in sperm
3) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.05 Pain Relevance 0
These results strongly suggest that proleolytic cleavage of PKC involves active caspase-3.
Protein_catabolism (cleavage) of PKC in cleavage
4) Confidence 0.24 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 0.37 Pain Relevance 0.21
That activation of pro-caspase-3 does indeed occur in glutamate-induced apoptotic cell death of primary rat cortical cells was confirmed by the demonstration that PKC, an endogenenous substrate of active caspase-3, was cleaved into two 45 kDa and 48 kDa BDPs [35,36].
Protein_catabolism (cleaved) of PKC in apoptotic cell associated with glutamate, apoptosis and death
5) Confidence 0.18 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 0.49 Pain Relevance 0.20
PKC isoenzymes are degraded in a differential manner upon A?
Protein_catabolism (degraded) of PKC associated with kinase c
6) Confidence 0.12 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.40 Pain Relevance 0.34
In contrast, a high degree of PKC ?
Protein_catabolism (degree) of PKC
7) Confidence 0.11 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1142330 Disease Relevance 1.12 Pain Relevance 0
Gravin is expressed in an extensive array of tissue including fibroblasts, vascular endothelium, neural crest derived cells, and portions of the central (cerebellum) and peripheral (peripheral nerve, myenteric plexus and satellite cells) nervous systems [7] SSeCKS (previously identified as clone 72, [8]) has been characterized as a substrate of PKC, PKA or rho family members [9-11].
Protein_catabolism (family) of PKC in nervous systems
8) Confidence 0.05 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.16 Pain Relevance 0.13

General Comments

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