INT181720

Context Info Confidence 0.20 First Reported 2005 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 3.65 Pain Relevance 1.79

endosome (IL15) aging (IL15) Golgi apparatus (IL15) cell-cell signaling (IL15) cytoplasm (IL15) extracellular space (IL15)

Anatomy Link Frequency NK cells 3 B lymphocytes 1 neutrophil 1 IL15 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 215 100.00 rheumatoid arthritis 140 96.72 tolerance 7 94.40 Inflammation 202 85.16 antagonist 41 81.68 anakinra 5 80.80 Kinase C 3 71.56 corticosteroid 86 71.52 abatacept 2 67.20 Bioavailability 12 60.24

Disease Link Frequency Relevance Heat Asthma 321 99.08 Cancer 35 98.36 Disease 136 97.16 Rheumatoid Arthritis 141 96.72 Urological Neuroanatomy 11 96.00 Severe Combined Immunodeficiency 2 91.60 Apoptosis 71 89.04 Anaemia 12 86.24 INFLAMMATION 227 85.16 Hypersensitivity 15 84.36

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

IL-15 is regulated by P (see above), and recent evidence suggests a central role for IL-15 in secretory phase endometrium in the recruitment of peripheral blood CD16-NK cells into the tissue in this phase of the cycle [35].

Regulation (regulated) of IL-15 in NK cells

1) Confidence 0.20 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775064 Disease Relevance 0.34 Pain Relevance 0.12

IL-15 is P-regulated and is important as a chemoattractant and stimulator of NK cell replication [26,27].

Regulation (regulated) of IL-15 in NK cell

2) Confidence 0.20 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775064 Disease Relevance 0 Pain Relevance 0

High levels of IL-7 and IL-15 mRNA and protein expression have been demonstrated in synovial tissue cells from RA patients [41].

Regulation (levels) of IL-15 associated with rheumatoid arthritis

3) Confidence 0.15 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 0.60 Pain Relevance 0.40

There are no clinical studies on the effect of IL-15 pathway modulation in asthmatic patients.

Regulation (effect) of IL-15 associated with asthma

4) Confidence 0.06 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.37 Pain Relevance 0.14

Some that are currently in development and at the trial stages are agents targeting IL-1, cytokines from the TNF superfamily, IL-15, IL-17, B lymphocytes, IL-12/IL-23, SyK kinase, JAK3 kinase, and inhibitors of osteoclastogenesis.40–51 Chemistry and mechanism of action

Regulation (targeting) of IL-15 in B lymphocytes associated with cytokine

5) Confidence 0.06 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2990387 Disease Relevance 0.36 Pain Relevance 0.43

Firstly, loss of NK cells and down regulation of IL-15 transmission may lad to impaired innate immunity and memory.

Regulation (regulation) of IL-15 in NK cells

6) Confidence 0.05 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.34 Pain Relevance 0.22

These cytokines include IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21.

Regulation (include) of IL-15 associated with cytokine

7) Confidence 0.04 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.19 Pain Relevance 0.30

No significant effects on systemic cytokines (IL-6, IL-12P40, IL-15, IL-17, IL-1?

Neg (No) Regulation (effects) of IL-15 associated with cytokine

8) Confidence 0.04 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.16 Pain Relevance 0.08

On the other hand, VAA-I could modulate the IL-15-induced neutrophil responses.

Regulation (modulate) of IL-15 in neutrophil

9) Confidence 0.04 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1062151 Disease Relevance 0.28 Pain Relevance 0.11

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