INT181729

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 16
Disease Relevance 1.21
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GP6)
Anatomy Link Frequency
platelet 5
GP6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 15 93.80 High High
agonist 75 90.32 High High
antagonist 46 56.64 Quite High
Pain 1 23.36 Low Low
Inflammation 2 23.00 Low Low
Inflammatory response 1 5.20 Low Low
anesthesia 15 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
complementary and alternative medicine 3 5.00 Very Low Very Low Very Low
bradykinin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 676 96.88 Very High Very High Very High
Paralysis 1 53.80 Quite High
Thrombosis 17 46.64 Quite Low
Nociception 1 27.80 Quite Low
Pain 1 23.36 Low Low
INFLAMMATION 3 23.00 Low Low
Bacterial Respiratory Disease 17 5.00 Very Low Very Low Very Low
Bacterial Infection 4 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These molecules can be found in several venoms such as botrocetin, a platelet-agglutinating protein (45), and bothrojaracin, a thrombin inhibitor, in B.jararaca venom (46,47); and convulxin, a pro-aggregating protein that binds to platelet GPVI receptor, in C.durissus terrificus venom (44,48,49) (Fig. 1).
GPVI Binding (binds) of in platelet
1) Confidence 0.35 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1062156 Disease Relevance 0.13 Pain Relevance 0.03
We have identified several peptides that interact with GpVI, in particular a peptide designated III-30 with the sequence GAOGLRGGAGPOGPEGGKGAAGPOGPO.
GpVI Binding (interact) of
2) Confidence 0.31 Published 2008 Journal Blood Section Abstract Doc Link PMC2602586 Disease Relevance 0.14 Pain Relevance 0.04
Peptide III-30 may prove a valuable tool for modeling and understanding the GpVI-collagen interaction, and provide insights into the differences between human and murine GpVI binding to collagen.
GpVI Binding (interaction) of
3) Confidence 0.31 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0 Pain Relevance 0.05
1(III)CB4 fragment6 contains most of its GpVI reactivity.
GpVI Binding (reactivity) of
4) Confidence 0.24 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.14 Pain Relevance 0
Peptide III-30 stands out as the best GpVI-binding substrate.
GpVI Binding (binding) of
5) Confidence 0.24 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.09 Pain Relevance 0
Modifications of the peptide sequence indicated that the hydroxyproline residues play a significant role in supporting its GpVI reactivity.
GpVI Binding (reactivity) of
6) Confidence 0.24 Published 2008 Journal Blood Section Abstract Doc Link PMC2602586 Disease Relevance 0.16 Pain Relevance 0.05
Peptides III-01b and III-01c were designed to reproduce the spacing of GPO and GPOGPO present in III-30; however, III-01b bound murine platelets and III-01c did not, further supporting our contention that GpVI binding is not determined solely by location and quantity of OGP/GPO motifs.
GpVI Binding (binding) of in platelets
7) Confidence 0.24 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.06 Pain Relevance 0
Although GPP is structurally similar to GPO, and would align with the CRP-binding site on GpVI,32 the interaction is thought to be too weak to sustain binding.
GpVI Binding (interaction) of
8) Confidence 0.24 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.14 Pain Relevance 0
These data indicate that the ability of a triple-helical peptide to bind GpVI is not solely determined by the presence or spatial arrangement of these OGP/GPO motifs within the peptides.



GpVI Binding (bind) of
9) Confidence 0.24 Published 2008 Journal Blood Section Abstract Doc Link PMC2602586 Disease Relevance 0.16 Pain Relevance 0.04
We have identified a major GpVI-binding locus that contains 3 HYP residues within OGP/GPO motifs.
GpVI Binding (binding) of
10) Confidence 0.23 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0 Pain Relevance 0
Recent work using peptides comprising both GPP and GPO triplets shows that platelet and GpVI binding increases with GPO content, such that maximum interaction requires at least 4 contiguous GPO triplets.16
GpVI Binding (binding) of in platelet
11) Confidence 0.23 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.05 Pain Relevance 0
These data indicate that GpVI interacts with specific loci in collagen and that motifs other than OGP/GPO contribute to these binding sites.


GpVI Binding (interacts) of
12) Confidence 0.23 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0 Pain Relevance 0
These data suggest that the particular spatial arrangement generated when collagen clusters GpVI is a significant determinant of the subsequent activation of the platelet and further support the view that the interactions of human and murine GpVI with collagen differ significantly.
GpVI Binding (interactions) of in platelet
13) Confidence 0.21 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0 Pain Relevance 0.03
The loss of the single GPO motif abolishes murine but not human platelet binding, highlighting potential differences between murine and human GpVI function.
GpVI Binding (binding) of in platelet
14) Confidence 0.21 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0 Pain Relevance 0
III-30 also supported binding of recombinant GpVI ectodomains.
recombinant GpVI Binding (binding) of
15) Confidence 0.21 Published 2008 Journal Blood Section Abstract Doc Link PMC2602586 Disease Relevance 0.15 Pain Relevance 0.05
Further work will identify those features of III-30 that contribute to GpVI-binding activity.



GpVI Binding (activity) of
16) Confidence 0.20 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0 Pain Relevance 0.04

General Comments

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