INT181738

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Context Info
Confidence 0.02
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.46
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Gtf3a) nucleus (Gtf3a) intracellular (Gtf3a)
DNA binding (Gtf3a)
Anatomy Link Frequency
glial cells 2
nucleus 2
Gtf3a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 23 100.00 Very High Very High Very High
Inflammatory response 7 96.28 Very High Very High Very High
Substantia nigra 4 72.80 Quite High
Spinal cord 1 70.12 Quite High
Inflammation 12 28.24 Quite Low
Inflammatory mediators 8 7.60 Low Low
Central nervous system 21 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
potassium channel 6 5.00 Very Low Very Low Very Low
adenocard 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 15 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
Disease Progression 5 98.08 Very High Very High Very High
Motor Neuron Diseases 11 97.60 Very High Very High Very High
INFLAMMATION 26 95.92 Very High Very High Very High
Disease 69 93.28 High High
Neurodegenerative Disease 17 89.28 High High
Drug Induced Neurotoxicity 6 87.80 High High
Apoptosis 9 86.16 High High
Tremor 1 85.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It may be noteworthy in this context that Müller cells are capable of secreting the vascular endothelial growth factor (VEGF) [37], [38], a key player in increasing the retinal vascular permeability.
Positive_regulation (increasing) of Localization (secreting) of factor
1) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.06 Pain Relevance 0
In another model evaluating the interaction between radiation and a monoclo-nal antibody, ionizing radiation was observed to trigger epidermal growth factor (EGF) import into the nucleus and as a consequence increase in DNA-repair kinase activity.
Positive_regulation (trigger) of Localization (import) of factor in nucleus
2) Confidence 0.01 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721318 Disease Relevance 0.35 Pain Relevance 0
A potential link between TLR signaling and an increase in neurotrophic factor secretion from glial cells may prove to be a therapeutic approach in ALS.


Positive_regulation (increase) of Localization (secretion) of factor in glial cells associated with motor neuron diseases
3) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 1.84 Pain Relevance 0.12
g/ml of the retentate fraction from Thujae occidentalis herba led to an increased secretion of the cytokines IL-1, IL-6 and tumor necrosis factor-?
Positive_regulation (increased) of Localization (secretion) of factor associated with necrosis, cancer and cytokine
4) Confidence 0.00 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1062158 Disease Relevance 0.20 Pain Relevance 0.13

General Comments

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