INT181744

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Context Info
Confidence 0.05
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 7.67
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (MLH1) nucleus (MLH1) cell cycle (MLH1)
MLH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 6 60.28 Quite High
endometriosis 6 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Taxol 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
pain pelvic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microsatellite Instability 126 99.48 Very High Very High Very High
Endometrial Cancer 213 99.06 Very High Very High Very High
Hereditary Nonpolyposis Colorectal Neoplasms 88 98.64 Very High Very High Very High
Ovarian Cancer 6 96.82 Very High Very High Very High
Colon Cancer 114 90.88 High High
Cancer 336 90.36 High High
Malignant Neoplastic Disease 23 89.64 High High
Carcinoma 30 84.32 Quite High
Syndrome 16 82.56 Quite High
Endometroid Carcinoma 36 81.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Feng et al. identified a B-raf mutation in 21% of patients with endometrial cancers and suggest that the mutation correlated with decreased hMLH1 expression [14].
Negative_regulation (decreased) of Gene_expression (expression) of hMLH1 associated with endometrial cancer
1) Confidence 0.05 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 1.43 Pain Relevance 0
Parc et al. demonstrated that 34% of young patients with endometrial cancer (median age 46) were associated with MI, 57% of the MI positive group showed an absence of hMLH1 expression, 19% showed an absence of hMLH2 expression, and 23.8% demonstrated a normal expression of both proteins, while 9.5% of all patients were diagnosed with Lynch syndrome [59].
Negative_regulation (absence) of Gene_expression (expression) of hMLH1 associated with microsatellite instability, endometrial cancer and hereditary nonpolyposis colorectal neoplasms
2) Confidence 0.04 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 2.03 Pain Relevance 0.06
Parc et al. demonstrated that 34% of young patients with endometrial cancer (median age 46) were associated with MI, 57% of the MI positive group showed an absence of hMLH1 expression, 19% showed an absence of hMLH2 expression, and 23.8% demonstrated a normal expression of both proteins, while 9.5% of all patients were diagnosed with Lynch syndrome [59].
Negative_regulation (absence) of Gene_expression (expression) of hMLH2 associated with microsatellite instability, endometrial cancer and hereditary nonpolyposis colorectal neoplasms
3) Confidence 0.04 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 2.07 Pain Relevance 0.06
Unlike classic Lynch syndrome, only 43% (6/14) of these MMR-deficient CRCs (by IHC) demonstrated loss of expression of one of the two major DNA MMR proteins, hMLH1 or hMSH2 (3 each for hMLH1 and hMSH2), together with the associated losses of hPMS2 or hMSH6.
Negative_regulation (loss) of Gene_expression (expression) of hMLH1 associated with hereditary nonpolyposis colorectal neoplasms
4) Confidence 0.01 Published 2007 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2736982 Disease Relevance 1.15 Pain Relevance 0
Interestingly, Watanabe and coworkers [9] described induction of MSI in ovarian tumours from patients studied before and after they received cisplatin-based chemotherapy, but in their study the cisplatin-induced MSI correlated with a significant decrease in hMLH1 expression.
Negative_regulation (decrease) of Gene_expression (expression) of hMLH1 associated with ovarian cancer and microsatellite instability
5) Confidence 0.00 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064099 Disease Relevance 1.00 Pain Relevance 0

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