INT181745

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Context Info
Confidence 0.48
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 5.73
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (MSH2) ATPase activity (MSH2) nucleus (MSH2)
enzyme binding (MSH2) DNA binding (MSH2)
MSH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 24 85.12 High High
cytokine 4 45.76 Quite Low
abdominal pain 4 44.16 Quite Low
palliative 6 35.36 Quite Low
peptic ulcer disease 1 31.76 Quite Low
alcohol 1 27.20 Quite Low
Pain 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Crohn's disease 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 72 99.86 Very High Very High Very High
Adenocarcinoma 30 99.72 Very High Very High Very High
Oral Lichen Planus 70 99.64 Very High Very High Very High
Hyperplasia 4 99.50 Very High Very High Very High
Microsatellite Instability 44 99.24 Very High Very High Very High
Familial Adenomatous Polyposis 7 93.20 High High
Skin Cancer 17 88.48 High High
Carcinoma 11 87.36 High High
Malignant Neoplastic Disease 16 87.24 High High
INFLAMMATION 22 85.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inactivation of hMSH2, one of the most commonly hMMR genes, is a described alternative pathway in cancer development and progression.
Positive_regulation (Inactivation) of hMSH2 associated with cancer
1) Confidence 0.48 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 1.55 Pain Relevance 0.11
As DNA damage is more prone to occur during the cell cycle, it can be assumed that a higher index of cellular proliferation in OLP would require an increased immunolocalization of hMSH2.
Positive_regulation (increased) of hMSH2 associated with oral lichen planus and hyperplasia
2) Confidence 0.45 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 1.23 Pain Relevance 0
We also observed an inverse correlation between the percentage of cells positive for hMSH2 and the number of MSI events per sample (P = 0.00019) and use of alkylating agents (P = 0.019).


Positive_regulation (positive) of hMSH2 associated with microsatellite instability
3) Confidence 0.01 Published 2005 Journal Breast Cancer Res Section Abstract Doc Link PMC1064099 Disease Relevance 0.98 Pain Relevance 0
An extensive study revealed all duodenal AC tumors to be positive for mismatch repair (MMR) on genes hMHL1 and hMSH2 but no mutations were found in the mutation cluster region (MCR) of the APC gene [66].
Positive_regulation (positive) of hMSH2 associated with adenocarcinoma and cancer
4) Confidence 0.01 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2949773 Disease Relevance 1.97 Pain Relevance 0

General Comments

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