INT181756

Context Info Confidence 0.46 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 4.12 Pain Relevance 0.28

signal transduction (Erbb2) plasma membrane (Erbb2) nucleus (Erbb2) kinase activity (Erbb2) cytoplasm (Erbb2)

Anatomy Link Frequency MDA-MB-468 1 brain 1 lung 1 Erbb2 (Mus musculus)

Pain Link Frequency Relevance Heat metalloproteinase 6 97.36 Inflammatory response 1 72.00 imagery 16 64.24 cINOD 2 62.32 aspirin 1 35.12 abdominal pain 1 30.92 positron emission tomography 9 5.00 cytokine 5 5.00 agonist 4 5.00 anesthesia 3 5.00

Disease Link Frequency Relevance Heat Lung Cancer 27 99.78 Breast Cancer 120 99.60 Cancer 160 99.16 Apoptosis 38 95.60 Non-small-cell Lung Cancer 13 95.20 Disease 5 92.76 Metastasis 28 91.48 Death 8 91.08 Recurrence 12 90.68 Malignant Neoplastic Disease 7 84.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The Her-2 oncogene can be activated by point mutations, gene amplification or over-expression and it is now well accepted that this predicts for a poor outcome in mammalian breast cancer [13,14] and is associated with ER negativity and nodal/brain metastasis.

Positive_regulation (activated) of Her-2 oncogene in brain associated with breast cancer and metastasis

1) Confidence 0.46 Published 2008 Journal Int Semin Surg Oncol Section Body Doc Link PMC2383915 Disease Relevance 0.66 Pain Relevance 0

In contrast, low 89Zr-DFO-trastuzumab accumulation in HER2/neu negative MDA-MB-468 tumors (mean and maximum T/M ratios of 2.26 and 4.15, respectively) was found to occur in accordance with the “enhanced permeation and retention” (EPR) mechanism.[58]

Positive_regulation (accumulation) of HER2/neu in MDA-MB-468 associated with cancer

2) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810330 Disease Relevance 0.70 Pain Relevance 0.03

Therefore, lung tumors with high levels of both EGFR and HER-2 may be appropriate for treatment with lapatinib.

Positive_regulation (levels) of HER-2 in lung associated with lung cancer

3) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 1.03 Pain Relevance 0

EGFR expression has also been linked to activation of ErbB2 in human breast cancers [22].

Positive_regulation (activation) of ErbB2 associated with breast cancer

4) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.16 Pain Relevance 0

, which transactivates the epidermal growth factor receptor, and epidermal growth factor receptor/c-erbB2 heterodimers, leading to a positive feedback loop in which cells exhibit increased proliferation and reduced apoptosis.

Positive_regulation (transactivates) of c-erbB2 associated with apoptosis

5) Confidence 0.21 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064113 Disease Relevance 1.02 Pain Relevance 0.24

Immunohistochemical stainings for oestrogen and progesterone receptors (Fig 4), GFCDP-15, C-ERB-B2 and CK 7 were positive.

Positive_regulation (positive) of C-ERB-B2

6) Confidence 0.00 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1550421 Disease Relevance 0.55 Pain Relevance 0

General Comments

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