INT181780

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.13
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGFBP7) extracellular region (IGFBP7) cell adhesion (IGFBP7)
Anatomy Link Frequency
margin 1
IGFBP7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 39 86.68 High High
fibrosis 3 36.48 Quite Low
metalloproteinase 3 5.16 Low Low
cytokine 5 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 3 100.00 Very High Very High Very High
Cancer 29 99.14 Very High Very High Very High
Dermal Scarring 48 98.64 Very High Very High Very High
Keloid Scars 6 96.26 Very High Very High Very High
Inflammatory Breast Neoplasms 134 87.12 High High
Advanced Or Metastatic Breast Cancer 13 86.88 High High
INFLAMMATION 29 86.68 High High
Breast Cancer 20 79.48 Quite High
Disease 31 53.92 Quite High
Internal Fibrosis 2 36.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The other 20 upregulated genes encoded growth factors (VEGF, DTR/HB-EGF, IGFBP7, IL-6, ANGPT2, EREG, CCL3/MIP1A, and CCL5/RANTES) or growth factor receptors (TBXA2R, TNFRSF10A/ TRAILR1, and ROBO2), mainly involved in angiogenesis.
Positive_regulation (upregulated) of IGFBP7
1) Confidence 0.40 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.08 Pain Relevance 0.08
The overexpression of SERPINH1, which showed a 5.7-fold upregulation in keloid margin in this study (P = .003), has been suggested to promote excessive collagen deposition in keloids.33 LGALS1 is a type of lectin that has been implicated in cell-cell and cell-matrix interactions and has been suggested to be involved in tumor progression, at least partly, through the induction of T-cell apoptosis.34 IGFBP7 shows a 2.8-fold upregulation in keloid margins (P = .022).
Positive_regulation (induction) of IGFBP7 in margin associated with dermal scarring, cancer, apoptosis and keloid scars
2) Confidence 0.35 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 1.05 Pain Relevance 0

General Comments

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