INT181781

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.77
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (FOSB) DNA binding (FOSB) transcription factor binding (FOSB)
Anatomy Link Frequency
nucleus 1
FOSB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 137 97.76 Very High Very High Very High
alcohol 2 70.00 Quite High
Inflammatory marker 3 60.88 Quite High
cytokine 60 19.44 Low Low
tolerance 3 9.40 Low Low
Arthritis 10 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
chemokine 9 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gauchers Disease 86 99.74 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 26 97.96 Very High Very High Very High
INFLAMMATION 133 97.76 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 285 96.16 Very High Very High Very High
Inflammatory Breast Neoplasms 268 94.52 High High
Breast Cancer 43 90.56 High High
Diabetes Mellitus 33 84.20 Quite High
Viral Infection 2 82.00 Quite High
Disease 74 71.12 Quite High
Nicotine Addiction 4 68.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 27 upregulated genes encoded seven transcription factors (JUN, EGR1, JUNB, FOS, FOSB, MYCN, and SNAIL1), four of which are components of the AP-1 transcription factor family (JUN, JUNB, FOS, and FOSB).
Positive_regulation (upregulated) of FOSB
1) Confidence 0.39 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.19 Pain Relevance 0.12
Although AP-1 proteins become constitutively expressed, the level of Ref-1, which is required for the DNA binding activity of AP-1, is significantly reduced in the nucleus of MDMs [201,202].
Positive_regulation (required) of AP-1 in nucleus
2) Confidence 0.31 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.21 Pain Relevance 0
B- and AP-1-mediated increase in LTR activity.
Positive_regulation (increase) of AP-1
3) Confidence 0.31 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.66 Pain Relevance 0
The 27 upregulated genes encoded seven transcription factors (JUN, EGR1, JUNB, FOS, FOSB, MYCN, and SNAIL1), four of which are components of the AP-1 transcription factor family (JUN, JUNB, FOS, and FOSB).
Positive_regulation (upregulated) of FOSB
4) Confidence 0.15 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.26 Pain Relevance 0.12
Rare variant forms of Gaucher disease result from deficiency of the sphingolipid activator protein, saposin C.3 Latterly, inherited defects in a recently discovered molecule, LIMP-2, have been associated with an usual phenotype with ?
Positive_regulation (deficiency) of activator protein associated with gauchers disease
5) Confidence 0.03 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC3010821 Disease Relevance 0.52 Pain Relevance 0
Furthermore, incadronate disodium significantly prevented transcriptional activation of nuclear factor-kappaB and activator protein-1 and the subsequent up-regulation of VEGF mRNA levels in AGE-exposed EC.
Positive_regulation (activation) of activator protein-1
6) Confidence 0.03 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.91 Pain Relevance 0.10

General Comments

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