INT181783

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Context Info
Confidence 0.71
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.44
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SNAI1) intracellular (SNAI1) cytoplasm (SNAI1)
SNAI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 43 96.48 Very High Very High Very High
cytokine 5 80.96 Quite High
chemokine 1 24.72 Low Low
palliative 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 191 99.60 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 13 96.68 Very High Very High Very High
INFLAMMATION 33 96.48 Very High Very High Very High
Recurrence 7 94.92 High High
Inflammatory Breast Neoplasms 134 93.24 High High
Breast Cancer 21 92.76 High High
Metastasis 41 90.52 High High
Colon Cancer 14 61.64 Quite High
Skin Cancer 21 57.04 Quite High
Disease 11 46.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, most of these studies have been carried out measuring RNA levels and should be interpreted with care since the expression of Snail1 mRNA and the corresponding protein levels do not always correlate, since Snail1 protein is very unstable and its half-life is controlled either by phosphorylation or lysine oxidation (see introduction).
Transcription (expression) of Snail1
1) Confidence 0.71 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.56 Pain Relevance 0.08
Similarly, high cytoplasmic FAK expression was not exclusively found in SNAI1-positive tumors pointing towards other mechanisms which may confer a migratory phenotype.
Neg (not) Transcription (found) of SNAI1 associated with cancer
2) Confidence 0.67 Published 2010 Journal BMC Clin Pathol Section Body Doc Link PMC2829523 Disease Relevance 0.70 Pain Relevance 0
The 27 upregulated genes encoded seven transcription factors (JUN, EGR1, JUNB, FOS, FOSB, MYCN, and SNAIL1), four of which are components of the AP-1 transcription factor family (JUN, JUNB, FOS, and FOSB).
Transcription (transcription) of SNAIL1
3) Confidence 0.05 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.17 Pain Relevance 0.09

General Comments

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