INT181787

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Context Info
Confidence 0.71
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 10.03
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ERBB2) signal transduction (ERBB2) plasma membrane (ERBB2)
nucleus (ERBB2) cytoplasm (ERBB2)
Anatomy Link Frequency
blood 2
ERBB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 15 77.20 Quite High
Inflammation 68 61.44 Quite High
addiction 4 39.52 Quite Low
opiate 1 37.76 Quite Low
Bioavailability 4 21.96 Low Low
Central nervous system 21 5.00 Very Low Very Low Very Low
palliative 7 5.00 Very Low Very Low Very Low
Codeine 4 5.00 Very Low Very Low Very Low
beta blocker 4 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 318 99.72 Very High Very High Very High
Inflammatory Breast Neoplasms 134 99.44 Very High Very High Very High
Adenocarcinoma 37 99.44 Very High Very High Very High
Noninfiltrating Intraductal Carcinoma 3 99.22 Very High Very High Very High
Skin Cancer 32 98.24 Very High Very High Very High
Carcinoma 19 97.52 Very High Very High Very High
Ductal Carcinoma 2 95.92 Very High Very High Very High
Disease 145 95.28 Very High Very High Very High
Non-small-cell Lung Cancer 81 91.76 High High
Carcinoma In Situ 6 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The HO-1, SOD-1, and SOD-2 transcript levels were significantly lower in the cancerous tissue, whereas no significant difference was apparent for both EGFR and HER-2 mRNA levels.
Transcription (levels) of HER-2
1) Confidence 0.71 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2911612 Disease Relevance 0.97 Pain Relevance 0.04
These guidelines have limitations, particularly the presumption of homogenous HER2 expression within a tumor.
Transcription (presumption) of HER2 associated with cancer
2) Confidence 0.64 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004582 Disease Relevance 0.63 Pain Relevance 0
Correlation between mRNA expression and CNA in ERBB2-amplified tumors
Transcription (expression) of ERBB2 associated with cancer
3) Confidence 0.63 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.37 Pain Relevance 0.03
ERBB2 mRNA expression, studied with northern blotting, is also high in IBC (overexpressed in 61%, compared with 39% in non-IBC) [22].
Transcription (expression) of ERBB2 associated with inflammatory breast neoplasms
4) Confidence 0.62 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 2.24 Pain Relevance 0.03
Furthermore, DCIS frequently overexpresses mutated p53, HER-2/neu,
Transcription (neu) of HER-2 associated with noninfiltrating intraductal carcinoma
5) Confidence 0.57 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 1.63 Pain Relevance 0
Such a correlation was not demonstrated for HER2, Top IIa, Ki 67 or p53.
Neg (not) Transcription (demonstrated) of HER2
6) Confidence 0.56 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410751 Disease Relevance 0.64 Pain Relevance 0
The HER-2 transcript levels prevailed in adenocarcinomas, whereas EGFR in squamocellular carcinomas.
Transcription (levels) of HER-2 associated with adenocarcinoma and carcinoma
7) Confidence 0.52 Published 2010 Journal Journal of Nucleic Acids Section Abstract Doc Link PMC2911612 Disease Relevance 0.49 Pain Relevance 0
Interestingly, the patients' prognosis shows a significant inverse association to the ratio of HER-2 transcript levels in the cancerous versus the unaffected tissue.
Transcription (levels) of HER-2
8) Confidence 0.52 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2911612 Disease Relevance 0.16 Pain Relevance 0
In agreement with this, 5-year survivors showed significantly lower HER-2 transcript levels in the cancerous versus the unaffected tissue than patients dead within 5 years from surgery (medians (interquartile ranges) of 0.48 (0.32–0.73) a.u. versus 1.39 (0.70–2.95) a.u., P < .05).
Transcription (levels) of HER-2
9) Confidence 0.52 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2911612 Disease Relevance 0.61 Pain Relevance 0
The levels of HER-2 mRNA were significantly higher in ADC than SCC tumor samples (median values of 0.38 (interquartile range 0.24–0.51) a.u. versus 0.10 (0.07–0.13) a.u., P < .001), whereas the difference was not significant for the EGFR transcript (Figure 1(a)).
Transcription (levels) of HER-2 associated with adenocarcinoma, cancer and skin cancer
10) Confidence 0.52 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2911612 Disease Relevance 0.85 Pain Relevance 0.03
Figure 1(b) shows the ratios of EGFR and HER-2 transcript levels in the cancerous versus unaffected tissues.
Transcription (levels) of HER-2
11) Confidence 0.52 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2911612 Disease Relevance 0.92 Pain Relevance 0.03
In the case of HER2, the qPCR assays are available both for the detection of HER2 amplification at the chromosome level and for HER2 transcripts in blood.
Transcription (detection) of HER2 in blood
12) Confidence 0.39 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.21 Pain Relevance 0
In the case of HER2, the qPCR assays are available both for the detection of HER2 amplification at the chromosome level and for HER2 transcripts in blood.
Transcription (detection) of HER2 in blood
13) Confidence 0.29 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.31 Pain Relevance 0

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