INT181801

Context Info Confidence 0.29 First Reported 2005 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.08 Pain Relevance 0

nucleoplasm (Atxn1) RNA binding (Atxn1) nucleus (Atxn1) cytoplasm (Atxn1)

Atxn1 (Mus musculus)

Pain Link Frequency Relevance Heat Calcium channel 2 22.64 agonist 2 16.00 Action potential 14 5.00 cerebral cortex 6 5.00 imagery 4 5.00 anesthesia 3 5.00 Thoracotomy 2 5.00 alcohol 2 5.00 Hippocampus 1 5.00

Disease Link Frequency Relevance Heat Repression 2 96.88 Disease 50 95.44 Myocardial Infarction 30 89.12 Apoptosis 6 76.48 Obesity 2 61.84 Targeted Disruption 35 56.28 Aging 6 54.44 Dilated Cardiomyopathy 2 53.48 Cerebellar Ataxia 1 41.76 Werner Syndrome 1 36.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Meanwhile, DNA damage by itself is shared by the SCA1 pathology through high mobility group protein B proteins (Qi et al., 2007), and it is still possible that other molecules regulate DNA damage in SCA1 in addition to HMGBs.

Spec (possible) Regulation (regulate) of SCA1

1) Confidence 0.29 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.77 Pain Relevance 0

population of CPS cells is replated onto a nontagged adherent monolayer of the purified Sca-1+ cells, the fluorescent Sca-1?

Regulation (replated) of Sca-1

2) Confidence 0.23 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064849 Disease Relevance 0.06 Pain Relevance 0

Thus, there is likely a role for the Sca-1+ fraction in engraftment efficiency through any number of mechanisms, including migration, tropism, and entrapment.

Regulation (role) of Sca-1

3) Confidence 0.23 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064849 Disease Relevance 0.25 Pain Relevance 0

General Comments

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