INT181804

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 57
Total Number 58
Disease Relevance 12.54
Pain Relevance 3.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 14
plaque 4
internal 4
eye 4
anterior 2
Tg(CAG-EGFP)D4Nagy (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 97 99.80 Very High Very High Very High
Pyramidal cell 92 99.16 Very High Very High Very High
imagery 243 99.04 Very High Very High Very High
GABAergic 171 98.20 Very High Very High Very High
Glutamate 19 88.80 High High
Spinal cord 319 88.56 High High
dorsal root ganglion 55 86.80 High High
Locus ceruleus 50 85.28 High High
medulla 26 84.64 Quite High
ischemia 24 78.00 Quite High
Disease Link Frequency Relevance Heat
Salivary Gland Disease 24 99.84 Very High Very High Very High
Targeted Disruption 286 99.70 Very High Very High Very High
Cold Sores 158 99.26 Very High Very High Very High
Cytomegalovirus Infection 126 99.24 Very High Very High Very High
Cancer 507 99.12 Very High Very High Very High
Sprains And Strains 113 98.12 Very High Very High Very High
Respiratory Syncytial Virus 109 97.64 Very High Very High Very High
Skin Cancer 27 97.16 Very High Very High Very High
Reprotox - General 1 44 97.04 Very High Very High Very High
Infection 322 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, if no EP were applied after injection of the eGFP22 Alexa labeled siRNA (anti-eGFP-EP) no reduction of the eGFP expression relative to controls was observed.
Neg (no) Negative_regulation (reduction) of Gene_expression (expression) of eGFP
1) Confidence 0.50 Published 2008 Journal Journal of RNAi and Gene Silencing : An International Journal of RNA and Gene Targeting Research Section Body Doc Link PMC2737239 Disease Relevance 0.50 Pain Relevance 0.03
This suggests that the level of eGFP expression decreased in most viable cells that had been permeabilized.
Negative_regulation (decreased) of Gene_expression (expression) of eGFP
2) Confidence 0.50 Published 2008 Journal Journal of RNAi and Gene Silencing : An International Journal of RNA and Gene Targeting Research Section Body Doc Link PMC2737239 Disease Relevance 0.24 Pain Relevance 0.06
Interestingly, when Ad5.CMV-GFP was injected intravitreally, the expression of GFP in the anterior segment was clearly higher than when it was injected intracamerally.
Negative_regulation (higher) of Gene_expression (expression) of GFP in anterior associated with cytomegalovirus infection
3) Confidence 0.38 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267727 Disease Relevance 0.27 Pain Relevance 0
The expression of GFP can be easily monitored by the green fluorescence.
Negative_regulation (monitored) of Gene_expression (expression) of GFP
4) Confidence 0.38 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267727 Disease Relevance 0.47 Pain Relevance 0.10
Furthermore, we defined experimental systems to visualize and quantify down-regulation of a constitutively expressed eGFP reporter gene, and the localization of siRNAs in subcutaneous B16-F10 melanoma tumors using fluorescence imaging.
Negative_regulation (regulation) of Gene_expression (expressed) of eGFP in B16-F10 associated with cancer, skin cancer and imagery
5) Confidence 0.37 Published 2008 Journal Journal of RNAi and Gene Silencing : An International Journal of RNA and Gene Targeting Research Section Body Doc Link PMC2737239 Disease Relevance 0.37 Pain Relevance 0.09
After day 7, GFP expression declined significantly.
Negative_regulation (declined) of Gene_expression (expression) of GFP
6) Confidence 0.33 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2267727 Disease Relevance 0.30 Pain Relevance 0
In agreement with a previous report by Filleur et al (2003), we did not observe any detectable reduction in eGFP expression after intratumoral injection of the eGFP22 siRNA alone (Figures 3). eGFP expression knockdown was only observed on the application of electric pulses.
Negative_regulation (reduction) of Gene_expression (expression) of eGFP
7) Confidence 0.32 Published 2008 Journal Journal of RNAi and Gene Silencing : An International Journal of RNA and Gene Targeting Research Section Body Doc Link PMC2737239 Disease Relevance 0.07 Pain Relevance 0.04
The TFA-GFP nanoparticles appeared to confer substantial levels of EGFP expression throughout the RPE and sparse expression in the ONL.
Negative_regulation (levels) of Gene_expression (expression) of EGFP
8) Confidence 0.32 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762345 Disease Relevance 0 Pain Relevance 0
Fluorescent microscopy at 48 h post-transduction revealed that transduction with HSV-U6shLacZ had no effect on GFP expression levels, whereas transduction with HSV-U6shGFP resulted in almost complete inhibition of GFP expression (Figure 4).
Negative_regulation (inhibition) of Gene_expression (expression) of GFP associated with cold sores
9) Confidence 0.21 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2504301 Disease Relevance 1.53 Pain Relevance 0.08
upregulation in the MG132-injected mice, it was possible to detect GFP?
Spec (possible) Negative_regulation (possible) of Gene_expression (detect) of GFP
10) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.22 Pain Relevance 0
detecting a 0.5 kB GFP band, against an internal 0.3 kB ?
Negative_regulation (0.5) of Gene_expression (band) of GFP in internal
11) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.11 Pain Relevance 0
Here we show that a generic serotype 2/9 AAV-GFP virus efficiently transfected neurons in the neocortex and drove green fluorescent protein (GFP) expression in both glutamatergic pyramidal neurons and GABAergic interneurons by a strong and ubiquitous CMV promoter, PCMV (Fig. 1a, and data not shown).
Negative_regulation (drove) of Gene_expression (expression) of GFP in pyramidal neurons associated with gabaergic, pyramidal cell and cytomegalovirus infection
12) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289876 Disease Relevance 0.23 Pain Relevance 0.13
The intensity of GFP expression in basket interneurons transfected by our AAV-LS1L-GFP virus at 15 days post-injection (dpi) was comparable to that of Thy1-GFP labeled pyramidal neurons in young adult mice [29]: GFP intensity at the somata of brightly labeled AAV-LS1L-GFP basket cells (GFPAAV:Pv) was 1.48+/?
Negative_regulation (intensity) of Gene_expression (expression) of GFP in basket cells associated with pyramidal cell
13) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289876 Disease Relevance 0.09 Pain Relevance 0.28
We therefore directly compared LacZ and GFP expression using immunohistochemistry.
Negative_regulation (compared) of Gene_expression (expression) of GFP
14) Confidence 0.15 Published 2007 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2526007 Disease Relevance 0 Pain Relevance 0.11
Furthermore, we found that the intensity of AAV-driven GFP expression was similar between pyramidal neurons in Emx-cre mice and basket interneurons in Pv-cre mice (GFPAAV:Emx/GFPThy1?
Negative_regulation (driven) of Gene_expression (expression) of GFP in interneurons associated with pyramidal cell
15) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289876 Disease Relevance 0.07 Pain Relevance 0.30
The number of GFP expressing neurons around the injection site can range from tens to thousands.
Negative_regulation (number) of Gene_expression (expressing) of GFP in neurons
16) Confidence 0.13 Published 2007 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2526007 Disease Relevance 0 Pain Relevance 0.03
Because the number of GFP expressing cells in each section was low, an alternative method was used to determine background fluorescence of GFP.
Negative_regulation (number) of Gene_expression (expressing) of GFP
17) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2900238 Disease Relevance 0 Pain Relevance 0.13
2 in Golgi cells by driving expression of GFP and GluR?
Negative_regulation (driving) of Gene_expression (expression) of GFP in Golgi cells
18) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2666267 Disease Relevance 0.06 Pain Relevance 0
Pre-treating cells with 75 pmol siGFP efficiently reduced eGFP expression in infected cells (Figure 1C), without having any effect on EHV-1 infectivity, i.e. plaque sizes and titers remained unaffected even though eGFP expression was no longer detectable (Figure 1C).
Negative_regulation (reduced) of Gene_expression (expression) of eGFP in plaque
19) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2606062 Disease Relevance 0.16 Pain Relevance 0
gp2 was used for in vitro studies because eGFP expression allows for ready identification of infected cells and virus-induced plaques.
Negative_regulation (allows) of Gene_expression (expression) of eGFP in plaques
20) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2606062 Disease Relevance 0.15 Pain Relevance 0

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