INT181805

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.78
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Atxn1) RNA binding (Atxn1) nucleus (Atxn1)
cytoplasm (Atxn1)
Anatomy Link Frequency
skeletal muscle 1
Atxn1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 1 66.24 Quite High
Calcium channel 2 55.72 Quite High
Pyramidal cell 9 25.00 Low Low
Action potential 14 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Thoracotomy 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spinocerebellar Ataxia Type 2 47 100.00 Very High Very High Very High
Death 5 92.56 High High
Carcinoma 14 91.20 High High
Disease 32 85.64 High High
Neurodegenerative Disease 7 83.12 Quite High
Disease Progression 1 79.44 Quite High
Depression 1 66.24 Quite High
Cognitive Disorder 9 59.20 Quite High
Huntington's Chorea 5 57.92 Quite High
Ataxia 3 57.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Early in SCA1, the production of several messenger RNAs (the templates for protein production) decreases, possibly because transcription factors (proteins that control gene expression) interact with the mutant protein.
Transcription (transcription) of SCA1 associated with spinocerebellar ataxia type 2
1) Confidence 0.69 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1880853 Disease Relevance 1.63 Pain Relevance 0.03
We also observed by qPCR analysis that Cd24a, Cd49f and Sca1 genes are transcribed in both subsets (Figure S3C).
Transcription (transcribed) of Sca1
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.15 Pain Relevance 0
When the skeletal muscle–derived Sca-1+ fraction of Spoc cells are plated under our conditions (see Materials and Methods) separately from the Sca-1?
Transcription (plated) of Sca-1 in skeletal muscle
3) Confidence 0.35 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064849 Disease Relevance 0 Pain Relevance 0.03
fraction, the former cells rapidly adhere to the plate and, with the exception of a few putative contaminating Sca-1?
Neg (exception) Transcription (exception) of Sca-1
4) Confidence 0.35 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064849 Disease Relevance 0 Pain Relevance 0

General Comments

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