INT181807

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.34
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 16
Disease Relevance 3.96
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Atxn1) RNA binding (Atxn1) nucleus (Atxn1)
cytoplasm (Atxn1)
Anatomy Link Frequency
hematopoietic stem cells 2
stem cell 2
striatum 1
stem 1
Atxn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 2 74.60 Quite High
anesthesia 8 59.80 Quite High
Tendonitis 5 51.60 Quite High
Dopamine 3 48.36 Quite Low
Inflammation 2 14.96 Low Low
Action potential 14 5.00 Very Low Very Low Very Low
antagonist 10 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Thoracotomy 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 59 97.80 Very High Very High Very High
Myocardial Infarction 168 97.68 Very High Very High Very High
Targeted Disruption 28 97.54 Very High Very High Very High
Cancer 210 97.40 Very High Very High Very High
Osteoporosis 195 97.16 Very High Very High Very High
Sprains And Strains 16 96.64 Very High Very High Very High
Breast Cancer 110 78.96 Quite High
Recurrence 6 75.16 Quite High
Obesity 9 61.84 Quite High
Overdose 2 59.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As both types of cells are derived from mice, the cells were examined for Sca-1 (stem cell antigen-1) activation.
Spec (examined) Positive_regulation (activation) of Sca-1 in stem cell
1) Confidence 0.34 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.21 Pain Relevance 0.05
We found that only undifferentiated mononucleated cells activate the Sca-1 gene (Figure 3).
Positive_regulation (activate) of Sca-1
2) Confidence 0.34 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.17 Pain Relevance 0
Further fractionation of Spoc cells by sorting for the Sca-1 marker (a cell-surface antigen found on murine hematopoietic stem cells [HSCs]) shows that the beating cells develop out of the Sca-1?
Positive_regulation (sorting) of Sca-1 in hematopoietic stem cells
3) Confidence 0.25 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064849 Disease Relevance 0 Pain Relevance 0.04
population of CPS cells is replated onto a nontagged adherent monolayer of the purified Sca-1+ cells, the fluorescent Sca-1?
Positive_regulation (fluorescent) of Sca-1
4) Confidence 0.25 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064849 Disease Relevance 0.06 Pain Relevance 0
The Sca-1 gene was activated only in undifferentiated mononucleated cells, as shown by the amplification of the 167-bp Sca-1 transcript (Figure 3(iii)).
Positive_regulation (activated) of Sca-1
5) Confidence 0.23 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.14 Pain Relevance 0
Sca-1 was activated only in undifferentiated mononucleated cells, indicating that the cells were hematopoietic stem cells.
Positive_regulation (activated) of Sca-1 in hematopoietic stem cells
6) Confidence 0.23 Published 2010 Journal Cancer Cell Int Section Abstract Doc Link PMC2984396 Disease Relevance 0.08 Pain Relevance 0
Activation of Opn, CatK, Sca-1 and Gapdh Genes
Positive_regulation (Activation) of Sca-1
7) Confidence 0.23 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.15 Pain Relevance 0
Our results are also in agreement with similar levels of instability seen in knock-in and fragment transgenic models of HD that exhibit different rates of inclusion formation [24], and with the observation that striatal instability occurs in SCA1 and DM1, although the striatum is not the target of pathogenesis in these disorders [2,5].


Positive_regulation (occurs) of SCA1 in striatum associated with targeted disruption and disease
8) Confidence 0.20 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2856555 Disease Relevance 0.70 Pain Relevance 0
The cells were then trypsinized for 1 minute, centrifuged, washed with PBS, fixed in 4% paraformaldehyde for 0.5 hour at room temperature, washed and blocked in 2%FCS for 0.5 hour at room temperature with agitation. 1.5×105cells were then incubated with each of the following conjugated monoclonal antibodies: Tie-2, Flk-1, CD34, c-Kit, Thy-1, Sca-1 (PharMingen, San Diego, CA) for 90 mins at room temperature.
Positive_regulation (incubated) of Sca-1
9) Confidence 0.19 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0.24 Pain Relevance 0.06
Like E-RoSH cells, plating of E-RoSHL1 cells on matrigel dramatically increased expression of endothelial markers such as Tie-2, Flk-1, c-kit, Sca1 and thy1 within 60 hours (fig. 5d) and they formed a network of vascular structures that covered the entire culture dish after one week (fig. 5e).


Positive_regulation (ly increa) of Sca1
10) Confidence 0.08 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0 Pain Relevance 0
Thus, while induction of Sca-1 supports the concept of progenitor cell activation, the molecular profile of the Sca-1-expressing population is distinct from that previously describe for BASCs [32], emphasizing the need for a better understanding of the phenotypic and functional characteristics of potential stem/progenitor cells in the lung.


Positive_regulation (induction) of Sca-1 in stem
11) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
The Sox17-induced Sca-1 positive cells located in the alveolar region did not coexpress proSP-C (Fig. 4F–N).
Positive_regulation (induced) of Sca-1
12) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Flow cytometric analysis indeed displayed a significant increase of LacZ+ cells in both Sca-1+ and CD31+ cell populations, parallel with an increase in total Sca+ and CD31+ cell numbers (Fig. 5a–d).
Positive_regulation (increase) of Sca-1
13) Confidence 0.06 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.40 Pain Relevance 0
Flow cytometric analysis showing a significant increase of LacZ+ cells in both Sca-1+ (b) and CD31+ (d) cell populations, parallel with an increase in total Sca+ (a) and CD31+ (c) cell numbers.
Positive_regulation (increase) of Sca-1
14) Confidence 0.06 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.79 Pain Relevance 0
In comparison to the non-treated cells, the number of cells expressing Sca-1 and MDR1 were enhanced by about 2-fold and 5-fold respectively after TGF?
Positive_regulation (enhanced) of Sca-1
15) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.16 Pain Relevance 0
or doxorubicin increased the number of 4T1 cells expressing stem cell marker Sca-1 and the drug resistant transporter protein MDR1, and with the stem cell property of self-renewal as indicated by mammosphere formation.
Positive_regulation (increased) of Sca-1 in stem cell
16) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.83 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox