INT181808

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Context Info
Confidence 0.54
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 6.22
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pax7) DNA binding (Pax7)
Anatomy Link Frequency
satellite cells 5
myoblasts 2
muscle 2
TEK 2
dorsal 1
Pax7 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 35 87.52 High High
cytokine 94 79.92 Quite High
anesthesia 20 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
tolerance 10 5.00 Very Low Very Low Very Low
Central nervous system 9 5.00 Very Low Very Low Very Low
chemokine 9 5.00 Very Low Very Low Very Low
ketamine 8 5.00 Very Low Very Low Very Low
Action potential 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 201 99.30 Very High Very High Very High
Chordoma 131 98.12 Very High Very High Very High
Appetite Loss 210 95.76 Very High Very High Very High
Cancer 496 95.40 Very High Very High Very High
Neuroblastoma 2 94.80 High High
Injury 25 92.68 High High
Apoptosis 19 90.40 High High
Chronic Renal Failure 10 90.20 High High
Body Weight 65 88.36 High High
Muscular Atrophy 130 87.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In C26 hosts, muscle wasting is also associated with increased Pax7 expression and reduced myogenin levels.
Gene_expression (expression) of Pax7 in muscle associated with frailty
1) Confidence 0.54 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2965098 Disease Relevance 0.80 Pain Relevance 0.04
While MyoD remains generally detectable, although at variable levels, high and low expression of Pax7 and myogenin, respectively, characterizes proliferating satellite cells, while the opposite pattern defines differentiating cells [43].
Gene_expression (expression) of Pax7 in satellite cells
2) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.35 Pain Relevance 0.07
The present study suggests an alternative mechanism based on ERK activation: when the C26 hosts are treated with PD, and ERK is thus inhibited, Pax7 and myogenin expression is restored to control values.
Gene_expression (expression) of Pax7
3) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.40 Pain Relevance 0
The present study demonstrates that in the muscle of the C26 hosts Pax7 expression is significantly increased with respect to controls, while myogenin levels are reduced.
Gene_expression (expression) of Pax7 in muscle
4) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.69 Pain Relevance 0
During differentiation, phosphorylated ERK, occurring at high levels over days 1–3, progressively declines concomitantly with Pax7 reduction and myogenin and MyoD increases (Fig.
Gene_expression (reduction) of Pax7
5) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.27 Pain Relevance 0
In previous reports Pax7 overexpression was found to result in inhibition of myogenesis [49].
Gene_expression (overexpression) of Pax7
6) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.74 Pain Relevance 0
ERK-dependent reduction in Pax7 expression was also shown in differentiating C2C12 myoblasts treated with myostatin [52].


Gene_expression (expression) of Pax7 in myoblasts
7) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.25 Pain Relevance 0
In the tibialis anterior of the C26 hosts we indeed detected by immunofluorescence microscopy increased levels of Pax7 and caveolin-1 (Fig. 5A), two markers of undifferentiated cells.
Gene_expression (levels) of Pax7 in tibialis anterior
8) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.54 Pain Relevance 0
Satellite cell phenotype is defined by the differential expression of specific factors, among which Pax7, MyoD and myogenin.
Gene_expression (expression) of Pax7 in Satellite cell
9) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.34 Pain Relevance 0.07
A different pattern can be observed for Pax7, whose expression in both differentiating myoblasts (Fig.
Gene_expression (expression) of Pax7 in myoblasts
10) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.23 Pain Relevance 0
Single Sk-34 cells typically showed no expression of Myf5, Pax3, Pax7, VE-cadherin or Nkx2.5, lower % expression of MyoD, M-cadherin, Cacn-1b, TEK, cardiac actin, GATA-4, Mef2c, Hand2 and isl-1, and higher (>50%) expression of c-met, Scn-1b, ?
Neg (no) Gene_expression (expression) of Pax7 in TEK
11) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.08 Pain Relevance 0
Single Sk-34 cells typically showed no expression of Myf5, Pax3, Pax7, VE-cadherin or Nkx2.5, lower % expression of MyoD, M-cadherin, Cacn-1b, TEK, cardiac actin, GATA-4, Mef2c, Hand2 and isl-1, and higher (>50%) expression of c-met, Scn-1b, ?
Gene_expression (expression) of Pax7 in TEK
12) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.08 Pain Relevance 0
At present, the most consistent and reliable marker for satellite cells is the paired-box transcription factor Pax7 and formation of satellite cells occurs via the expression of Pax7 and MyoD and/or Myf5 [30], [31], [32].
Gene_expression (expression) of Pax7 in satellite cells
13) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.14 Pain Relevance 0
At present, the most consistent and reliable marker for satellite cells is the paired-box transcription factor Pax7 and formation of satellite cells occurs via the expression of Pax7 and MyoD and/or Myf5 [30], [31], [32].
Gene_expression (expression) of Pax7 in satellite cells
14) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.14 Pain Relevance 0
The transplant population also expressed additional markers for neural precursors (Sox1) as well as anterior (Otx1) and ventral forebrain markers (Mash1, Nkx2.1) and dorsal markers (Pax7), demonstrating the presence of broad regional identities in these cultures (Figure S1D).


Gene_expression (expressed) of Pax7 in dorsal
15) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.08 Pain Relevance 0.08
These include Olig3, Neurog2(Ngn2), Ascl1(Mash1), Gsh1, Gsh2, Math1, Pax3, Pax7, and Ptf1a.
Gene_expression (include) of Pax7
16) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0
Spoc cells are distinguished from satellite cells by the following criteria: (1) Spoc cells do not express Pax-7 [21] or the surface marker c-met [22]; (2) approximately the same number of Spoc cells are isolated from both young (less than 4-wk-old) and older (12- to 16-wk-old) mice, whereas satellite cells are difficult to isolate from normal mouse muscle after 8 wk of age without first inducing muscle injury [21]; (3) at isolation, Spoc cells remain round floating cells approximately 4 ?
Neg (not) Gene_expression (express) of Pax-7 in satellite cells associated with injury
17) Confidence 0.26 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064849 Disease Relevance 0.09 Pain Relevance 0
They include the paired box 7 (PAX7) gene encoding a transcriptional factor expressed in the neural tube which is regulated by notochord specific signals [76], the differentially screening-selected gene aberrant in neuroblastoma (DAN), involved in the negative regulation of cell proliferation [77], the Dishevelled 1 gene (DVL1), a key factor in Wnt signalling expressed in the neural tube [78] and a few genes belonging to the tumour necrosis factor receptor superfamily (TNFRSF-1B, -8, -9, -14), the DNA fragmentation factor (DFF-A and- B) and TP73 [UCSC], all acting in apoptotic pathways.
Gene_expression (expressed) of PAX7 in notochord associated with necrosis, neuroblastoma, cancer and apoptosis
18) Confidence 0.17 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837065 Disease Relevance 1.00 Pain Relevance 0

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