INT181812

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Context Info
Confidence 0.66
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 13.47
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Msc) DNA binding (Msc)
Anatomy Link Frequency
endothelial cells 2
astrocyte 2
T lymphocytes 2
blood 1
striatum 1
Msc (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 77 99.92 Very High Very High Very High
Central nervous system 50 90.40 High High
imagery 71 83.68 Quite High
Arthritis 34 80.56 Quite High
chemokine 31 76.24 Quite High
rheumatoid arthritis 70 53.24 Quite High
Inflammation 67 53.12 Quite High
Neuropeptide 2 29.48 Quite Low
GABA receptor 1 28.40 Quite Low
Somatostatin 3 26.92 Quite Low
Disease Link Frequency Relevance Heat
Cancer 1390 99.98 Very High Very High Very High
Lymphatic System Cancer 248 99.92 Very High Very High Very High
Apoptosis 72 99.84 Very High Very High Very High
Middle Cerebral Artery Infarction 85 98.44 Very High Very High Very High
Shock 4 98.14 Very High Very High Very High
Aggression 36 98.08 Very High Very High Very High
Stroke 135 97.00 Very High Very High Very High
Solid Tumor 14 96.66 Very High Very High Very High
Severe Combined Immunodeficiency 43 95.60 Very High Very High Very High
Epstein-barr Virus 20 92.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, specific bHLH genes, including those encoding NeuroD1, NeuroD6, Msc, and Nhlh2, were increased, and, perhaps consistent with this, the inhibitory bHLH factor Id1, which can act to oppose the action of neurogenic bHLH genes, was decreased.
Positive_regulation (increased) of Msc
1) Confidence 0.66 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.18 Pain Relevance 0
Of note, increasing the amount of injected MSC to a lymphoma?
Positive_regulation (increasing) of MSC associated with lymphatic system cancer
2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886845 Disease Relevance 0.79 Pain Relevance 0
Intra-peritoneal (i.p.) injection of MSC (4 days after i.p. injection of lymphoma cells) significantly increased the overall survival at an optimal MSC?
Positive_regulation (increased) of MSC associated with lymphatic system cancer
3) Confidence 0.57 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2886845 Disease Relevance 1.69 Pain Relevance 0.03
Thus, although we were unable to document the relevance of these in vitro data in our animal models, our findings suggest the existence of a complex interplay between MSC, lymphoma cells and endothelial cells, characterized by: i) a significant release of pro-angiogenic/pro-migratory cytokines by MSC, which is enhanced by the presence of lymphoma cells; ii) a potent chemotactic activity of MSC on endothelial cells, followed by a cytotoxic activity of MSC on endothelial cells, which required the MSC/endothelial cell contact.
Positive_regulation (enhanced) of MSC in endothelial cell associated with lymphatic system cancer and cytokine
4) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886845 Disease Relevance 0.59 Pain Relevance 0.11
In parallel, in MSC/HUVEC co-cultures, we documented a progressive collapse of the endothelial cell monolayer, with the prevalence of dead endothelial cells nearby the MSC and a significant increase of apoptotic cells, quantified by Annexin-V/PI double staining (Figure 5B–C).
Positive_regulation (increase) of MSC in endothelial cells associated with shock and apoptosis
5) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886845 Disease Relevance 0.47 Pain Relevance 0
We do not exclude a contribution from other parenchymal cells to the MSC enhanced tPA activity; however, the high concentration of astrocytes in the IBZ and the predominance of numbers astrocytes in parenchymal tissue, suggest that the astrocyte is a robust contributor to the MSC mediated tPA activity and subsequent functional recovery.
Positive_regulation (mediated) of MSC in astrocyte
6) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.18 Pain Relevance 0
We therefore sought to identify the key restorative factors that promote MSC stimulated neurite outgrowth.
Positive_regulation (promote) of MSC in neurite
7) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.27 Pain Relevance 0.12
We do not exclude a contribution from other parenchymal cells to the MSC enhanced tPA activity; however, the high concentration of astrocytes in the IBZ and the predominance of numbers astrocytes in parenchymal tissue, suggest that the astrocyte is a robust contributor to the MSC mediated tPA activity and subsequent functional recovery.
Positive_regulation (enhanced) of MSC in astrocytes
8) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.31 Pain Relevance 0
Axonal fiber density in the IBZ of the striatum was significantly increased after MSC treatment (Fig. 6c, 6d) compared with MCAo control animals (Fig. 6b, 6d).
Positive_regulation (increased) of MSC in striatum associated with middle cerebral artery infarction
9) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.66 Pain Relevance 0
These data suggest that, although we cannot exclude a contribution of MSC induced neuroprotection to the MSC mediated increase in axonal fiber density and synaptophysin expression, the reduction in apoptosis likely plays a minor role in the observed white matter remodeling.


Positive_regulation (increase) of MSC in white matter associated with apoptosis
10) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 1.12 Pain Relevance 0
In the following sections, we provide in vivo evidence of the expression of these factors only in tumors that have an admixed population of MSC, thereby illustrating the MSC involvement as a TAF within the tumor microenvironment.


Positive_regulation (population) of MSC associated with cancer
11) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.86 Pain Relevance 0
We show the “activation” of MSC by tumor conditioned media by the increase of TAF-like surface markers (Figure 1A).
Positive_regulation (activation) of MSC in TAF associated with cancer
12) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.89 Pain Relevance 0
TAF marker expression in tumors harboring MSC
Positive_regulation (harboring) of MSC associated with cancer
13) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.92 Pain Relevance 0
Accordingly, we suggest that several growth factors mediate the transition from the tumor supportive MSC to the tumor supportive TAF.
Positive_regulation (supportive) of MSC associated with cancer
14) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.86 Pain Relevance 0
The ability of MSC to travel to solid tumors after intravenous administration and their ability to develop myofibroblast-like characteristics under defined culture conditions [20] both suggest that TAF could be derived from MSC.
Positive_regulation (derived) of MSC associated with solid tumor
15) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 1.29 Pain Relevance 0
Growth factors stain in patches that do not correlate with the more sparse staining patterns of the TAF markers themselves due to the fact that the tumor cells also secrete the growth factors HGF, IL-6 and EGF in the presence of MSC as demonstrated by in vitro co-culture data (Figure S4).


Positive_regulation (presence) of MSC in HGF associated with cancer
16) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 1.33 Pain Relevance 0.04
Castrated mice had elevated MSC recruitment to the epithelial compartment of the prostate (mean?
Positive_regulation (elevated) of MSC
17) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944821 Disease Relevance 0.05 Pain Relevance 0.10
Antibody MSC 21 was generated after peripheral blood injection of Spoc cells into rats (performed by Antibody Solutions, Palo Alto, California, United States).
Positive_regulation (generated) of MSC in blood
18) Confidence 0.13 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064849 Disease Relevance 0 Pain Relevance 0
In MSC-treated immunized mice, CD4+CD25+CD27+ Tregs were increased significantly compared with non-MSC-treated mice, and Tregs from these mice inhibited proliferation of T lymphocytes when proliferation was recalled using collagen type II.
Positive_regulation (increased) of MSC in T lymphocytes
19) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592798 Disease Relevance 0.48 Pain Relevance 0.23
In MSC-treated immunized mice, CD4+CD25+CD27+ Tregs were increased significantly compared with non-MSC-treated mice, and Tregs from these mice inhibited proliferation of T lymphocytes when proliferation was recalled using collagen type II.
Positive_regulation (increased) of MSC in T lymphocytes
20) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592798 Disease Relevance 0.53 Pain Relevance 0.23

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