INT181813

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 3.47
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Atxn1) RNA binding (Atxn1) nucleus (Atxn1)
cytoplasm (Atxn1)
Anatomy Link Frequency
hematopoietic stem cells 2
tail vein 2
stem cell 2
Atxn1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 1 76.00 Quite High
Inflammation 54 65.32 Quite High
Spinal cord 46 61.00 Quite High
Thoracotomy 4 52.56 Quite High
Calcium channel 3 45.64 Quite Low
anesthesia 8 30.00 Quite Low
Central nervous system 37 28.64 Quite Low
Pyramidal cell 9 25.00 Low Low
cytokine 20 18.56 Low Low
Action potential 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spinocerebellar Ataxia Type 2 47 100.00 Very High Very High Very High
Infarction 15 91.00 High High
Disease Progression 1 89.20 High High
Myocardial Infarction 114 88.16 High High
Cancer 354 85.44 High High
Death 7 83.76 Quite High
Multiple Sclerosis 88 77.72 Quite High
Targeted Disruption 45 77.68 Quite High
Disease 60 76.84 Quite High
Carcinoma 29 76.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Could the progression of SCA1 be slowed, therefore, by using an agent that affects gene expression?
Negative_regulation (slowed) of Gene_expression (progression) of SCA1 associated with spinocerebellar ataxia type 2
1) Confidence 0.42 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1880853 Disease Relevance 1.46 Pain Relevance 0.04
While the RNA levels of the Cd24a and Cd49f genes positively correlated with increased cell density, expression of the Sca1 decreased as a function of cell density (Figure 10C).
Negative_regulation (decreased) of Gene_expression (expression) of Sca1
2) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0 Pain Relevance 0
Cellular subsets sorted according to expression of CD24a, CD49f, CD61, Epcam, Sca1, and Thy1 cell surface proteins, or metabolic markers (e.g.
Negative_regulation (sorted) of Gene_expression (expression) of Sca1
3) Confidence 0.23 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920333 Disease Relevance 0.65 Pain Relevance 0
This finding is consistent with our in vitro findings described earlier, in which purified Sca-1?
Negative_regulation (which) of Gene_expression (purified) of Sca-1
4) Confidence 0.21 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064849 Disease Relevance 0.33 Pain Relevance 0
With the Sca-1+ population removed, the remaining Sca-1?
Negative_regulation (removed) of Gene_expression (population) of Sca-1
5) Confidence 0.21 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064849 Disease Relevance 0 Pain Relevance 0
Four hours after irradiation, mice were injected via the tail vein with either 1.5 × 105 GFP+/Sca-1?
Negative_regulation (irradiation) of Gene_expression (injected) of Sca-1 in tail vein
6) Confidence 0.21 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064849 Disease Relevance 0.15 Pain Relevance 0.03
The onset of differentiation after 5 days of culture and the gradual loss of Sca-1, c-Kit and Musashi-1 expression after 3 days of culture indicated that for subsequent functional experiments employing transplantation, cells that had been cultured for 3 days were most suitable.


Negative_regulation (loss) of Gene_expression (expression) of Sca-1
7) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2329592 Disease Relevance 0 Pain Relevance 0
No expression of MHC class II, CD80, CD86, CD133, Sca1, and c-kit (CD117) was detected, indicating that BM-MC still have an immature phenotype, but without expressing stem cell surface markers (Figure 2A).
Negative_regulation (detected) of Gene_expression (expression) of Sca1 in stem cell
8) Confidence 0.14 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 0.39 Pain Relevance 0.09
Also, flow cytometry analysis revealed that the bone marrow cell compartments enriched in long-term repopulating hematopoietic stem cells, defined here as KLS (c-Kit+ Sca1+ lineages?)
Negative_regulation (defined) of Gene_expression (lineages) of Sca1 in hematopoietic stem cells
9) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759285 Disease Relevance 0 Pain Relevance 0
LacZ+ cells displayed expression of both Sca-1 and CD31 on their cell surface (Fig. 4a).
Negative_regulation (displayed) of Gene_expression (expression) of Sca-1
10) Confidence 0.05 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.49 Pain Relevance 0

General Comments

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