INT181817

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 58
Total Number 60
Disease Relevance 43.24
Pain Relevance 7.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
lipid metabolic process (Ppara)
Anatomy Link Frequency
kidney 6
monocytes 6
hepatocytes 4
fibroblasts 4
brain 2
Ppara (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 729 100.00 Very High Very High Very High
cytokine 307 100.00 Very High Very High Very High
Inflammation 997 99.90 Very High Very High Very High
Crohn's disease 8 99.86 Very High Very High Very High
Multiple sclerosis 59 99.62 Very High Very High Very High
ischemia 31 98.12 Very High Very High Very High
aspirin 65 95.84 Very High Very High Very High
Central nervous system 118 95.04 Very High Very High Very High
cINOD 223 93.84 High High
cva 1 89.56 High High
Disease Link Frequency Relevance Heat
Shock 611 100.00 Very High Very High Very High
Atherosclerosis 194 100.00 Very High Very High Very High
Sprains And Strains 122 100.00 Very High Very High Very High
Polyps 95 100.00 Very High Very High Very High
Cancer 1137 99.98 Very High Very High Very High
Intestinal Cancer 38 99.92 Very High Very High Very High
INFLAMMATION 1164 99.90 Very High Very High Very High
Disease 460 99.86 Very High Very High Very High
Targeted Disruption 189 99.84 Very High Very High Very High
Metabolic Disorder 75 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
on obesity, due in part to reductions in hepatic expression of PPAR?
Negative_regulation (reductions) of Gene_expression (expression) of PPAR associated with obesity
1) Confidence 0.58 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.32 Pain Relevance 0
An additional and intriguing aspect of inflammation is the putative link between inflammation and impaired PPAR expression.
Negative_regulation (impaired) of Gene_expression (expression) of PPAR associated with inflammation
2) Confidence 0.57 Published 2010 Journal PPAR Research Section Body Doc Link PMC2748193 Disease Relevance 1.14 Pain Relevance 0.21
play a central role in mediating PPAR-induced effects

[7–9], and the expression of both PPARs and RXRs decreases

Negative_regulation (decreases) of Gene_expression (expression) of PPAR
3) Confidence 0.57 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.53 Pain Relevance 0.46
MS

patients showed a decrease in the expression of PPAR?

Negative_regulation (decrease) of Gene_expression (expression) of PPAR associated with multiple sclerosis
4) Confidence 0.53 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 1.23 Pain Relevance 0.52
Decreased expression of Ppara has also been observed in aging heart, liver, and kidney [72] and recently it has been broadly implicated in aging and systemic inflammation [73].
Negative_regulation (Decreased) of Gene_expression (expression) of Ppara in kidney associated with aging and inflammation
5) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975639 Disease Relevance 0.78 Pain Relevance 0.05
However, the knockdown of FATP3 (ACSLV3) in primary rat hepatocytes revealed a significant reduction in the expression of several lipogenic transcription factors, PPAR?
Negative_regulation (reduction) of Gene_expression (expression) of PPAR in hepatocytes
6) Confidence 0.43 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.23 Pain Relevance 0
on obesity, due in part to reductions in hepatic expression of PPAR?
Negative_regulation (reductions) of Gene_expression (expression) of PPAR associated with obesity
7) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.32 Pain Relevance 0
Thus, inhibition of the actions of PPAR?
Negative_regulation (inhibition) of Gene_expression (actions) of PPAR
8) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.56 Pain Relevance 0
As mentioned above, both PPAR?
Negative_regulation (above) of Gene_expression (mentioned) of PPAR
9) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.61 Pain Relevance 0.03
The RXR/PPAR heterodimer is activated by
Negative_regulation (The) of Gene_expression (heterodimer) of PPAR
10) Confidence 0.42 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.30 Pain Relevance 0.30
Although preliminary, these data confirm previous studies in which radiation has been shown to reduce PPAR expression within hours to several days of treatment in the kidney [102] and the colon [103].
Negative_regulation (reduce) of Gene_expression (expression) of PPAR in kidney
11) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2748193 Disease Relevance 0.74 Pain Relevance 0.23
showed inversed phase in response to daytime feeding corresponding to altered expression of PPAR?
Negative_regulation (altered) of Gene_expression (expression) of PPAR
12) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0 Pain Relevance 0.10
isotypes, the expression of PPAR?
Negative_regulation (isotypes) of Gene_expression (expression) of PPAR
13) Confidence 0.41 Published 2010 Journal PPAR Research Section Body Doc Link PMC2748193 Disease Relevance 0.33 Pain Relevance 0.08
, but not PPAR?
Neg (not) Negative_regulation (not) of Gene_expression (but) of PPAR
14) Confidence 0.41 Published 2008 Journal Thromb J Section Body Doc Link PMC2396603 Disease Relevance 0.46 Pain Relevance 0
We dissected the contribution of PPAR?
Negative_regulation (dissected) of Gene_expression (contribution) of PPAR
15) Confidence 0.40 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.84 Pain Relevance 0.07
The species differences may be attributable to lower PPAR mRNA expression levels in h-hepatocytes compared with rodent cells [56, 57].
Negative_regulation (lower) of Gene_expression (expression) of PPAR mRNA in hepatocytes
16) Confidence 0.40 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.19 Pain Relevance 0.04
published concerning hemodynamic parameters in the brain of PPAR?
Negative_regulation (published) of Gene_expression (brain) of PPAR in brain
17) Confidence 0.39 Published 2008 Journal PPAR Research Section Body Doc Link PMC2581793 Disease Relevance 0.93 Pain Relevance 0.28
expression of IL-12 family cytokines by PPAR agonists suggests this be a
Negative_regulation (cytokines) of Gene_expression (expression) of PPAR agonists associated with agonist and cytokine
18) Confidence 0.39 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 0.38 Pain Relevance 0.38
In

addition, the development of selective PPAR modulators (SPPARMs), rather than

Negative_regulation (development) of Gene_expression (modulators) of PPAR
19) Confidence 0.39 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.78 Pain Relevance 0.21
Several potential downstream targets of PPAR?
Negative_regulation (downstream) of Gene_expression (targets) of PPAR
20) Confidence 0.39 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422873 Disease Relevance 1.52 Pain Relevance 0

General Comments

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