INT181823

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 23
Disease Relevance 6.45
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppargc1a) RNA binding (Ppargc1a) mitochondrion organization (Ppargc1a)
nucleus (Ppargc1a) DNA binding (Ppargc1a) transcription factor binding (Ppargc1a)
Anatomy Link Frequency
ventricle 2
cardiac myocytes 2
muscle 2
Ppargc1a (Mus musculus)
Pain Link Frequency Relevance Heat
electroacupuncture 328 98.76 Very High Very High Very High
fibrosis 50 96.16 Very High Very High Very High
Acupuncture 40 94.72 High High
cerebral cortex 20 71.60 Quite High
adenocard 2 69.24 Quite High
Inflammation 10 67.00 Quite High
medulla 8 59.36 Quite High
cOX1 4 53.04 Quite High
cytokine 8 52.76 Quite High
alcohol 16 50.00 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 40 100.00 Very High Very High Very High
Diabetes Mellitus 116 99.52 Very High Very High Very High
Insulin Resistance 220 99.26 Very High Very High Very High
Lifespan 25 96.88 Very High Very High Very High
Fibrosis 50 96.16 Very High Very High Very High
Hypertrophy 45 95.24 Very High Very High Very High
Obesity 205 93.16 High High
Stress 86 90.56 High High
Left Ventricular Hypertrophy 50 89.08 High High
Coronary Heart Disease 69 82.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biochemical analysis of these cells also revealed an
                       increase in the expression of PGC-1? 
Positive_regulation (increase) of Gene_expression (expression) of PGC
1) Confidence 0.67 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC2837205 Disease Relevance 0.18 Pain Relevance 0
In response to glucagon, protein kinase A phosphorylates transcription factor CREB at Ser133 and increases its transcriptional activity (23), which activates the expression of PGC-1?
Positive_regulation (activates) of Gene_expression (expression) of PGC
2) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.09 Pain Relevance 0.03
These results indicate that high ROS levels activate CREB phosphorylation and result in increased expression of PGC-1?.
Positive_regulation (result) of Gene_expression (expression) of PGC
3) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.07 Pain Relevance 0
Lastly, forced expression of PGC-1?
Positive_regulation (forced) of Gene_expression (expression) of PGC-1
4) Confidence 0.66 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064854 Disease Relevance 0.37 Pain Relevance 0
Third, studies in primary cardiac myocytes in culture and in the hearts of transgenic mice have demonstrated that overexpression of PGC-1?
Positive_regulation (overexpression) of Gene_expression (overexpression) of PGC-1 in cardiac myocytes associated with targeted disruption
5) Confidence 0.66 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064854 Disease Relevance 0.37 Pain Relevance 0
This is somewhat supported by our current data of upregulated PGC-1?
Positive_regulation (supported) of Gene_expression (data) of PGC
6) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.25 Pain Relevance 0
This result indicates that the reduced expression of PGC-1?
Positive_regulation (indicates) of Gene_expression (expression) of PGC
7) Confidence 0.49 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.08 Pain Relevance 0
Specifically, low-frequency EA improved insulin sensitivity in a mouse model of genetic insulin resistance and diabetes, at least in part, via stimulation of SIRT1/PGC-1?
Positive_regulation (stimulation) of Gene_expression (/) of PGC-1 associated with diabetes mellitus, insulin resistance and electroacupuncture
8) Confidence 0.46 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.69 Pain Relevance 0.31
Meanwhile, electric stimulation such as exercise induces muscle contraction, which has been observed to activate SIRT1/PGC-1?
Positive_regulation (activate) of Gene_expression (/) of PGC-1 in muscle
9) Confidence 0.46 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.71 Pain Relevance 0.37
Collectively, these studies support the possibility that EA improves insulin sensitivity, at least partially, because of increasing SIRT1/PGC-1?
Positive_regulation (increasing) of Gene_expression (/) of PGC-1 associated with electroacupuncture
10) Confidence 0.46 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.44 Pain Relevance 0.15
These results indicate that high ROS levels activate CREB phosphorylation and result in increased expression of PGC-1?.
Positive_regulation (increased) of Gene_expression (expression) of PGC
11) Confidence 0.45 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.07 Pain Relevance 0
Forced expression of PGC-1?
Positive_regulation (Forced) of Gene_expression (expression) of PGC-1
12) Confidence 0.45 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064854 Disease Relevance 0.07 Pain Relevance 0.10
Overexpression of PGC-1?
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of PGC-1
13) Confidence 0.43 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.37 Pain Relevance 0.25
Overexpression of CCNH, but not RASA1, resulted in significantly increased levels of mitochondrial density and oxidative phosphorylation, similar to those observed with overexpression of PGC-1?
Positive_regulation (overexpression) of Gene_expression (overexpression) of PGC-1
14) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0.24 Pain Relevance 0
Second, forced expression studies in adipogenic and myogenic mammalian cell lines demonstrated that PGC-1?
Positive_regulation (demonstrated) of Gene_expression (demonstrated) of PGC-1
15) Confidence 0.42 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064854 Disease Relevance 0.36 Pain Relevance 0
MAT1 down-regulation had no effect, in agreement with findings that this protein is dispensable for basal expression of PGC-1 target genes [26].
Positive_regulation (dispensable) of Gene_expression (expression) of PGC-1
16) Confidence 0.29 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0.29 Pain Relevance 0
As shown in Figure 6B, aortic constriction (1 day) induced a rapid increase in the expression of PGC-1?
Positive_regulation (induced) of Gene_expression (expression) of PGC-1
17) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0 Pain Relevance 0
All three siRNAs against CCNH induced a significant decrease in mitochondrial density and oxidative phosphorylation, similar to what is observed with knock-down of PGC-1?
Positive_regulation (induced) of Gene_expression (down) of PGC-1 associated with targeted disruption
18) Confidence 0.27 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0.26 Pain Relevance 0
We detected that the depletion of MEF2C also results in lowered levels of both PGC-1?
Positive_regulation (results) of Gene_expression (levels) of PGC-1
19) Confidence 0.20 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2794538 Disease Relevance 0.73 Pain Relevance 0.08
Basal myocardial expression of PGC-1?
Positive_regulation (myocardial) of Gene_expression (expression) of PGC-1
20) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0 Pain Relevance 0

General Comments

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