INT181829

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 9.61
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppargc1a) RNA binding (Ppargc1a) mitochondrion organization (Ppargc1a)
nucleus (Ppargc1a) DNA binding (Ppargc1a) transcription factor binding (Ppargc1a)
Anatomy Link Frequency
neuronal 1
skeletal muscle 1
Ppargc1a (Mus musculus)
Ppargc1a - G482S (6)
Pain Link Frequency Relevance Heat
electroacupuncture 82 95.72 Very High Very High Very High
addiction 2 90.24 High High
Hippocampus 3 88.56 High High
tolerance 25 84.32 Quite High
cytokine 5 38.12 Quite Low
imagery 16 29.96 Quite Low
ischemia 3 25.44 Quite Low
adenocard 3 21.68 Low Low
Pain 2 10.44 Low Low
Spinal cord 8 6.32 Low Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 248 99.80 Very High Very High Very High
Appetite Loss 15 99.80 Very High Very High Very High
Hypertension 139 99.76 Very High Very High Very High
Cancer 98 99.62 Very High Very High Very High
Muscular Atrophy 110 99.34 Very High Very High Very High
Left Ventricular Dysfunction 32 98.76 Very High Very High Very High
Obesity 171 98.44 Very High Very High Very High
Metabolic Syndrome 10 98.20 Very High Very High Very High
Insulin Resistance 44 97.76 Very High Very High Very High
Diabetes Mellitus 163 96.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the association between PPARGC1A and diastolic dysfunction might be secondary, through these intermediate phenotypes.
PPARGC1A Spec (might) Binding (association) of associated with coronary heart disease
1) Confidence 0.48 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2637232 Disease Relevance 1.20 Pain Relevance 0
Future work aimed at uncovering these mechanisms, beginning with an examination of the subcellular localization, post-translational modifications, and protein interactions of PGC-1?
PGC Binding (interactions) of
2) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.33 Pain Relevance 0
A recent large meta-analysis comprising of 13 949 individuals from 17 studies, of which 6 042 were from previously unpublished datasets, failed to find an association of the PPARGC1A Gly482Ser polymorphism with hypertension overall.
PPARGC1A (G482S) Binding (association) of associated with hypertension
3) Confidence 0.37 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2637232 Disease Relevance 0.94 Pain Relevance 0
The interaction between PPARGC1A Gly482Ser and sex was non-significant upon formal testing, which could be due to low statistical power to detect interactions.
PPARGC1A (G482S) Binding (interaction) of
4) Confidence 0.37 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2637232 Disease Relevance 0.65 Pain Relevance 0
Moreover, PPARGC1A interacts with estrogen receptors and enhances their transcriptional activity [44].
PPARGC1A Binding (interacts) of
5) Confidence 0.37 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2637232 Disease Relevance 0.48 Pain Relevance 0
There are
                       several reports on how CR induces the deacetylation of PGC-1? 
PGC Binding (deacetylation) of
6) Confidence 0.36 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC2837205 Disease Relevance 0.21 Pain Relevance 0.07
The results presented here indicate that PGC-1?
PGC Binding (indicate) of
7) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.15 Pain Relevance 0
Recently, skeletal muscle atrophy due to cancer cachexia has been linked to reduced PGC-1?
PGC Binding (linked) of in skeletal muscle associated with appetite loss, cancer and muscular atrophy
8) Confidence 0.36 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1950512 Disease Relevance 1.06 Pain Relevance 0.04
and coactivates with PGC-1?
PGC Binding (coactivates) of
9) Confidence 0.36 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.33 Pain Relevance 0
However, the analyses were stratified on sex according to our a priori analysis plan based on the hypothesis that the association between PPARGC1A Gly482Ser and diastolic dysfunction could differ by sex.
PPARGC1A (G482S) Binding (association) of associated with coronary heart disease
10) Confidence 0.36 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2637232 Disease Relevance 0.41 Pain Relevance 0
The PPARGC1A Gly482Ser polymorphism has also been associated with hypertension in previous studies [15-17].
PPARGC1A (G482S) Binding (associated) of associated with hypertension
11) Confidence 0.36 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2637232 Disease Relevance 1.14 Pain Relevance 0
Although the results were different for men and women, the interaction between PPARGC1A Gly482Ser and sex was non-significant upon formal testing (p = 0.19).
PPARGC1A (G482S) Binding (interaction) of
12) Confidence 0.36 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2637232 Disease Relevance 0.66 Pain Relevance 0
Analyses were stratified on sex according to our a priori analysis plan based on the hypothesis that the association between PPARGC1A Gly482Ser and diastolic dysfunction could differ by sex.
PPARGC1A (G482S) Binding (association) of associated with coronary heart disease
13) Confidence 0.36 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2637232 Disease Relevance 0.32 Pain Relevance 0
First, PGC-1?
PGC-1 Binding (First) of
14) Confidence 0.31 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064854 Disease Relevance 0.25 Pain Relevance 0
Intriguingly, PGC-1?
PGC-1 Binding (Intriguingly) of
15) Confidence 0.30 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.49 Pain Relevance 0.15
in neuronal metabolism (St-Pierre et al 2006) and the link between resveratrol, SIRT-1, and PGC-1?
PGC-1 Binding (link) of in neuronal
16) Confidence 0.05 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546476 Disease Relevance 0.99 Pain Relevance 0.08
Similarly, PGC-1 has been shown to undergo a conformational change upon NR binding [Puigserver et al., 1999].
PGC-1 Binding (binding) of
17) Confidence 0.05 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0

General Comments

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