INT181833

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 6.01
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppargc1a) RNA binding (Ppargc1a) mitochondrion organization (Ppargc1a)
nucleus (Ppargc1a) DNA binding (Ppargc1a) transcription factor binding (Ppargc1a)
Anatomy Link Frequency
muscle 2
skeletal muscle 1
Ppargc1a (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 76 97.68 Very High Very High Very High
cOX1 1 93.44 High High
Central nervous system 22 86.56 High High
Pyramidal cell 8 75.44 Quite High
cerebral cortex 20 73.44 Quite High
Inflammation 16 58.96 Quite High
Acupuncture 10 51.52 Quite High
electroacupuncture 82 50.00 Quite Low
agonist 24 40.20 Quite Low
cytokine 13 37.72 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 57 99.64 Very High Very High Very High
Appetite Loss 15 99.60 Very High Very High Very High
Insulin Resistance 129 99.56 Very High Very High Very High
Cancer 83 99.42 Very High Very High Very High
Muscular Atrophy 10 99.14 Very High Very High Very High
Impaired Glucose Tolerance 65 97.68 Very High Very High Very High
Hypoxia 2 90.96 High High
Obesity 382 90.16 High High
Congenital Anomalies 69 88.24 High High
Targeted Disruption 104 86.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, in nondiabetic rodents, inhibition of PGC-1?
Negative_regulation (inhibition) of PGC
1) Confidence 0.57 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.45 Pain Relevance 0.08
In the present study, we demonstrated that downregulation of PGC-1?
Negative_regulation (downregulation) of PGC
2) Confidence 0.57 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.05 Pain Relevance 0.03
MKO mice along with impaired Pgc-1?
Negative_regulation (impaired) of Pgc
3) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775956 Disease Relevance 0.09 Pain Relevance 0
Recently, skeletal muscle atrophy due to cancer cachexia has been linked to reduced PGC-1?
Negative_regulation (reduced) of PGC in skeletal muscle associated with appetite loss, cancer and muscular atrophy
4) Confidence 0.57 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1950512 Disease Relevance 1.06 Pain Relevance 0.04
Disruption of PGC-1?
Negative_regulation (Disruption) of PGC
5) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.16 Pain Relevance 0
Leptin deficiency was associated with a reduction of Pgc-1?
Negative_regulation (reduction) of Pgc-1
6) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.54 Pain Relevance 0
Leptin deficiency was associated with a reduction of Pgc-1?
Negative_regulation (reduction) of Pgc
7) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.54 Pain Relevance 0
These data indicate that downregulation of PGC-1?
Negative_regulation (downregulation) of PGC
8) Confidence 0.41 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.20 Pain Relevance 0.05
single nucleotide polymorphisms and haplotypes may influence the development of insulin resistance and diabetes [27,30] and that PGC-1 activity is diminished in insulin-resistant and diabetic muscle [22,23].
Negative_regulation (diminished) of PGC-1 in muscle associated with diabetes mellitus and insulin resistance
9) Confidence 0.41 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064854 Disease Relevance 0.75 Pain Relevance 0.11
Consistent with this notion, we and others have shown that mice lacking the PGC-1?
Negative_regulation (lacking) of PGC-1
10) Confidence 0.41 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064854 Disease Relevance 0.82 Pain Relevance 0.12
In addition, we found that triglyceride synthesis was abnormally activated, and the expression of genes encoding SREBP-1c and SCD-1, key proteins in the hepatic lipogenic pathway, failed to be appropriately down-regulated in fasted PGC-1??
Neg (failed) Negative_regulation (regulated) of PGC-1
11) Confidence 0.36 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064854 Disease Relevance 0.07 Pain Relevance 0
target involved in mitochondrial DNA replication/transcription, was diminished in PGC-1??
Negative_regulation (diminished) of PGC-1
12) Confidence 0.36 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064854 Disease Relevance 0.13 Pain Relevance 0
High-fat-diet-induced insulin resistance occurs together with decreased muscle PGC-1?
Negative_regulation (decreased) of PGC-1 in muscle associated with insulin resistance
13) Confidence 0.34 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.81 Pain Relevance 0.10
It is worth noting that the magnitude of the changes observed with CCNH knockdown matches those observed with knockdown of PGC-1?
Negative_regulation (knockdown) of PGC-1
14) Confidence 0.26 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0.33 Pain Relevance 0

General Comments

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