INT181848

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 8.14
Pain Relevance 2.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CD14) extracellular region (CD14) plasma membrane (CD14)
Anatomy Link Frequency
monocytes 7
macrophages 2
CD86 1
CD14 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 29 99.60 Very High Very High Very High
Inflammation 160 96.68 Very High Very High Very High
spinal inflammation 34 95.96 Very High Very High Very High
anesthesia 85 95.80 Very High Very High Very High
cytokine 133 95.56 Very High Very High Very High
antagonist 26 83.52 Quite High
chemokine 17 73.72 Quite High
Inflammatory stimuli 4 72.48 Quite High
Opioid 4 69.00 Quite High
Morphine 11 68.28 Quite High
Disease Link Frequency Relevance Heat
Dengue Hemorrhagic Fever 201 99.68 Very High Very High Very High
Dengue 189 99.36 Very High Very High Very High
Sepsis 90 98.60 Very High Very High Very High
INFLAMMATION 191 96.68 Very High Very High Very High
Disease 83 96.28 Very High Very High Very High
Low Back Pain 34 95.96 Very High Very High Very High
Chlamydia Infection 88 90.48 High High
Infection 181 89.68 High High
Stress 34 87.84 High High
Injury 35 85.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decreased expression of HLA-DR was obtained for 69% of the plasma samples (9 out of 13 patients), with a 42 ± 9% decrease for CD14HIGH and a 11 ± 8% decrease for CD14LOW monocytes.
Negative_regulation (decrease) of CD14LOW in monocytes
1) Confidence 0.43 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.07
Decreased expression of HLA-DR was obtained for 69% of the plasma samples (9 out of 13 patients), with a 42 ± 9% decrease for CD14HIGH and a 11 ± 8% decrease for CD14LOW monocytes.
Negative_regulation (decrease) of CD14HIGH in monocytes
2) Confidence 0.43 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.07
Deciphering the acting mediators associated with HLA-DR down-regulation on CD14HIGH and CD14LOW monocytes
Negative_regulation (regulation) of CD14HIGH in monocytes
3) Confidence 0.31 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.09 Pain Relevance 0.29
Deciphering the acting mediators associated with HLA-DR down-regulation on CD14HIGH and CD14LOW monocytes
Negative_regulation (regulation) of CD14LOW in monocytes
4) Confidence 0.31 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.09 Pain Relevance 0.29
This was consistent with the study by de Kruif et al. [37], who found that CD14 was down-regulated in Indonesian children with DSS, relative to DF and DHF cases.
Negative_regulation (regulated) of CD14 associated with dengue and dengue hemorrhagic fever
5) Confidence 0.30 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2886038 Disease Relevance 1.32 Pain Relevance 0
CD14 was also down-regulated in DSS patients from Vietnam [10].
Negative_regulation (down) of CD14 associated with dengue hemorrhagic fever
6) Confidence 0.30 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2886038 Disease Relevance 1.25 Pain Relevance 0
This was consistent with the study by de Kruif et al. [37], who found that CD14 was down-regulated in Indonesian children with DSS, relative to DF and DHF cases.
Negative_regulation (down) of CD14 associated with dengue and dengue hemorrhagic fever
7) Confidence 0.30 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2886038 Disease Relevance 1.32 Pain Relevance 0
A potential mechanism whereby endotoxin-tolerance develops is a down-regulation of LPS receptors such as membrane CD14 on macrophages [70].
Negative_regulation (regulation) of CD14 in macrophages associated with tolerance
8) Confidence 0.29 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 0.60 Pain Relevance 0.42
The HLA-DR downregulation on the CD14LOW subset, which is increased during sepsis [29], was transient and less severe.
Negative_regulation (downregulation) of CD14LOW associated with sepsis
9) Confidence 0.27 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.26 Pain Relevance 0.08
Differentiation of the monocytes into dendritic cells in non-infected individuals occurred as expected, with a relatively higher expression of CD11c and an absence lack of CD14 (Fig. 1A).
Negative_regulation (lack) of CD14 in monocytes
10) Confidence 0.26 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.20 Pain Relevance 0
When primary human monocytes are treated with ATRA (all-trans retinoic acid), TLR 2 and CD14 are downregulated without any change in expression of TLR 1 and 4 [142].
Negative_regulation (downregulated) of CD14 in monocytes
11) Confidence 0.22 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 0.85 Pain Relevance 0.33
CD14 was reduced from 10.6 ± 16.6% before treatment to 2.5 ± 2% after treatment (P = 0.011), TLR4 was reduced from 46.9 ± 32.7% to 11.7 ± 12.5% (P = 0.008) and TLR2 was reduced from 11.7 ± 19.4% to 1.8 ± 2.9% (P = 0.012).


Negative_regulation (reduced) of CD14
12) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.28 Pain Relevance 0.18
They demonstrated a dose dependent decrease of TLR4 mRNA and protein expression in CD14+ human monocytes incubated in vitro with simvastatin or atorvastatin.
Negative_regulation (decrease) of CD14 in monocytes
13) Confidence 0.15 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.31 Pain Relevance 0.58
Our group alongside others have established that OECs immunophenotype consists of multiple endothelial markers and complete absence of haematopoietic markers such as CD45 and CD14 [23,32].
Negative_regulation (absence) of CD14
14) Confidence 0.13 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0.33 Pain Relevance 0.07
The CD14/TLR complex and associated signaling pathways are essential for the recognition of LPS by macrophages, and several studies suggest that down-regulation of CD14/TLR complexes on macrophages is responsible for the development of tolerance [63,70,75,76].
Negative_regulation (regulation) of CD14 in macrophages associated with tolerance
15) Confidence 0.13 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 0.35 Pain Relevance 0.46
After 7 days of cultivation in vitro, the cells turned into DCs, as indicated by the loss of CD14 receptors and the upregulation of HLA-DR, CD80 and CD86 receptors (data not shown).
Negative_regulation (loss) of CD14 in CD86
16) Confidence 0.07 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064864 Disease Relevance 0.90 Pain Relevance 0.10

General Comments

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