INT18185

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Context Info
Confidence 0.76
First Reported 1987
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 32
Total Number 35
Disease Relevance 12.52
Pain Relevance 8.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Tyr) cell proliferation (Tyr) oxidoreductase activity (Tyr)
cytoplasm (Tyr)
Anatomy Link Frequency
melanocyte 4
SK-MEL-28 2
tail 2
ears 2
macrophage 1
Tyr (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 115 100.00 Very High Very High Very High
Enkephalin 3 100.00 Very High Very High Very High
aspirin 12 99.84 Very High Very High Very High
Neuropeptide 24 99.80 Very High Very High Very High
Paracetamol 25 98.18 Very High Very High Very High
Analgesic 118 95.76 Very High Very High Very High
Opioid 76 95.60 Very High Very High Very High
agonist 24 94.50 High High
antagonist 28 94.26 High High
narcan 63 91.68 High High
Disease Link Frequency Relevance Heat
Cancer 187 100.00 Very High Very High Very High
Microphthalmia 18 100.00 Very High Very High Very High
Skin Cancer 38 99.76 Very High Very High Very High
Glioblastoma 26 99.16 Very High Very High Very High
Experimental Melanoma 6 98.60 Very High Very High Very High
Targeted Disruption 132 96.92 Very High Very High Very High
Injury 51 93.68 High High
Toxicity 16 93.12 High High
Recurrence 4 91.56 High High
Myocardial Infarction 3 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was also found that APAP selectively caused escalation in reactive oxygen species (ROS) formation and intracellular GSH (ICG) depletion in melanocytic human SK-MEL-28 and murine B16-F0 melanoma cells that express functional tyrosinase whereas it lacked significant effects on ROS formation and ICG in amelanotic C32 melanoma cells that do not express functional tyrosinase.
Gene_expression (express) of tyrosinase in SK-MEL-28 associated with paracetamol and skin cancer
1) Confidence 0.76 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19513568 Disease Relevance 1.32 Pain Relevance 0.77
Down-regulation of tyrosinase expression by acetylsalicylic acid in murine B16 melanoma.
Gene_expression (expression) of tyrosinase associated with aspirin and experimental melanoma
2) Confidence 0.76 Published 2008 Journal Biol. Pharm. Bull. Section Title Doc Link 18175938 Disease Relevance 0.60 Pain Relevance 0.29
ASA inhibited tyrosinase expression in a dose-dependent manner.
Gene_expression (expression) of tyrosinase
3) Confidence 0.76 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18175938 Disease Relevance 0.52 Pain Relevance 0.16
Therefore, the depigmenting effect of ASA might be due to inhibition of tyrosinase expression or enhancement of tyrosinase degradation.
Gene_expression (expression) of tyrosinase
4) Confidence 0.76 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18175938 Disease Relevance 0.49 Pain Relevance 0.15
Furthermore, K14-SCF Tyr(c2j/c2j) animals demonstrated tyrosinase expression and enzymatic activity, suggesting that the c2j Tyr defect can be rescued in part by SCF in the ears and tail.
Gene_expression (expression) of tyrosinase in tail
5) Confidence 0.75 Published 2009 Journal Pigment Cell Melanoma Res Section Abstract Doc Link 19682281 Disease Relevance 0.16 Pain Relevance 0.09
Stem cell factor rescues tyrosinase expression and pigmentation in discreet anatomic locations in albino mice.
Gene_expression (expression) of tyrosinase in pigmentation
6) Confidence 0.75 Published 2009 Journal Pigment Cell Melanoma Res Section Title Doc Link 19682281 Disease Relevance 0.18 Pain Relevance 0.08
It was also found that APAP selectively caused escalation in reactive oxygen species (ROS) formation and intracellular GSH (ICG) depletion in melanocytic human SK-MEL-28 and murine B16-F0 melanoma cells that express functional tyrosinase whereas it lacked significant effects on ROS formation and ICG in amelanotic C32 melanoma cells that do not express functional tyrosinase.
Neg (not) Gene_expression (express) of tyrosinase in SK-MEL-28 associated with paracetamol and skin cancer
7) Confidence 0.66 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19513568 Disease Relevance 1.38 Pain Relevance 0.79
These genes encoded enzymes involved in melanogenesis, including tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT), as well as melanosomal matrix proteins such as SILV and MLANA.
Gene_expression (including) of TYR
8) Confidence 0.65 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 1.26 Pain Relevance 0
Here we report analyses regarding expression of the melanocyte-stimulating hormone (MSH) receptor (melanocortin-1 receptor, MC1-R) and the melanogenic proteins, tyrosinase (E.C. 1.14.18.1), tyrosinase-related protein 1 (TRP-1), and the tyrosinase-related protein 2 (TRP-2, E.C. 5.3.2.3), by a panel of cell lines consisting of parental Cloudman S91 melanoma cells, macrophages from DBA/2J mice, artificially derived macrophage x melanoma hybrids of high and low metastatic potential, and a naturally occurring highly metastatic hybrid between a Cloudman S91 tumor cell and a DBA/2J tumor-infiltrating cell.
Spec (analyses) Gene_expression (expression) of tyrosinase in macrophage associated with melanocortin 1 receptor, cancer and skin cancer
9) Confidence 0.63 Published 1999 Journal Pigment Cell Res. Section Abstract Doc Link 10614575 Disease Relevance 0.60 Pain Relevance 0.17
3'-Hydroxyacetaminophen, a catechol metabolite of N-acetyl-p-aminophenol (acetaminophen) and N-acetyl-m-aminophenol (a structural analogue of acetaminophen and considered as a possible alternative because it is not hepatotoxic), is enzymatically synthesized for the first time using mushroom tyrosinase.
Gene_expression (synthesized) of tyrosinase associated with paracetamol
10) Confidence 0.58 Published 2003 Journal Biotechnol. Prog. Section Abstract Doc Link 14656133 Disease Relevance 0 Pain Relevance 0.45
Furthermore, K14-SCF Tyr(c2j/c2j) animals demonstrated tyrosinase expression and enzymatic activity, suggesting that the c2j Tyr defect can be rescued in part by SCF in the ears and tail.
Gene_expression (defect) of Tyr in tail
11) Confidence 0.57 Published 2009 Journal Pigment Cell Melanoma Res Section Abstract Doc Link 19682281 Disease Relevance 0.15 Pain Relevance 0.09
A pigmented subclone of this microcell hybrid, however, re-expressed the tyrosinase, TRP-1, TRP-2, and microphthalmia genes.
Gene_expression (expressed) of tyrosinase associated with microphthalmia
12) Confidence 0.56 Published 1996 Journal Somat. Cell Mol. Genet. Section Abstract Doc Link 8643993 Disease Relevance 0.34 Pain Relevance 0
Since the only fibroblast chromosome detected in the unpigmented microcell hybrid was mouse chromosome 1, these results also suggest that the extinguisher locus affecting the expression of the tyrosinase, TRP-1, TRP-2, and microphthalmia genes in hybrid cells is located on that mouse chromosome (or on a fragment of another chromosome present in the unpigmented monochromosomal microcell hybrid but undetected in our analyses).
Gene_expression (expression) of tyrosinase in fibroblast associated with microphthalmia
13) Confidence 0.56 Published 1996 Journal Somat. Cell Mol. Genet. Section Abstract Doc Link 8643993 Disease Relevance 0.33 Pain Relevance 0.07
These data demonstrate that pTT treatment increases eumelanogenesis in HFs, associated with increased tyrosinase, TRP-1 and MC-1R expression.
Gene_expression (expression) of tyrosinase
14) Confidence 0.48 Published 2007 Journal Exp. Dermatol. Section Abstract Doc Link 17620094 Disease Relevance 0 Pain Relevance 0.07
Two O-glucopeptides, H-Tyr(beta-D-Glc)-Gly-Gly-Phe-OH(10) and H-Tyr(beta-D-Glc)-Gly-Gly-Phe-Leu-OH (11), having the amino acid sequence of enkephalin, were synthesized to determine the influence of the carbohydrate molecule on the biological activity and conformation of these opioid peptides.
Gene_expression (synthesized) of H-Tyr associated with enkephalin and opioid
15) Confidence 0.46 Published 1987 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 3692684 Disease Relevance 0 Pain Relevance 0.34
Analysis of melanocyte-specific transcripts using reverse transcription, combined with the polymerase chain reaction (RT-PCR), demonstrated that tyrosinase, TRP-1, TRP-2, and microphthalmia transcripts were all absent in unpigmented whole-cell hybrids and in the monochromosomal unpigmented microcell hybrid.
Neg (absent) Gene_expression (absent) of tyrosinase in melanocyte associated with microphthalmia
16) Confidence 0.43 Published 1996 Journal Somat. Cell Mol. Genet. Section Abstract Doc Link 8643993 Disease Relevance 0.33 Pain Relevance 0
A pigmented subclone of this microcell hybrid, however, re-expressed the tyrosinase, TRP-1, TRP-2, and microphthalmia genes.
Gene_expression (-) of tyrosinase associated with microphthalmia
17) Confidence 0.43 Published 1996 Journal Somat. Cell Mol. Genet. Section Abstract Doc Link 8643993 Disease Relevance 0.34 Pain Relevance 0
Mouse E(+)/E(+) melanocytes, but not e/e or E(so)/E(so) melanocytes, respond to agouti signaling protein with decreased basal tyrosinase activity, and reduction in levels of tyrosinase and tyrosinase-related proteins 1 and 2.
Gene_expression (levels) of tyrosinase in melanocytes
18) Confidence 0.43 Published 2001 Journal J. Cell. Sci. Section Abstract Doc Link 11181184 Disease Relevance 0 Pain Relevance 0.54
Mouse E(+)/E(+) melanocytes, but not e/e or E(so)/E(so) melanocytes, respond to agouti signaling protein with decreased basal tyrosinase activity, and reduction in levels of tyrosinase and tyrosinase-related proteins 1 and 2.
Gene_expression (levels) of tyrosinase in melanocytes
19) Confidence 0.43 Published 2001 Journal J. Cell. Sci. Section Abstract Doc Link 11181184 Disease Relevance 0 Pain Relevance 0.54
Furthermore, K14-SCF Tyr(c2j/c2j) animals demonstrated tyrosinase expression and enzymatic activity, suggesting that the c2j Tyr defect can be rescued in part by SCF in the ears and tail.
Gene_expression (expression) of tyrosinase in ears
20) Confidence 0.25 Published 2009 Journal Pigment Cell Melanoma Res Section Abstract Doc Link 19682281 Disease Relevance 0.16 Pain Relevance 0.09

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