INT181862

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Context Info
Confidence 0.16
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.18
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MPO) aging (MPO) enzyme binding (PRTN3)
cytosol (PRTN3) peptidase activity (PRTN3) extracellular space (MPO)
Anatomy Link Frequency
monocyte 1
MPO (Homo sapiens)
PRTN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 100 90.16 High High
cytokine 8 90.16 High High
Infliximab 87 87.28 High High
Inflammation 8 68.08 Quite High
imagery 1 59.12 Quite High
fibrosis 1 53.12 Quite High
spinal inflammation 56 50.00 Quite Low
cva 4 29.28 Quite Low
methotrexate 25 5.00 Very Low Very Low Very Low
Etanercept 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 17 100.00 Very High Very High Very High
Disease 50 90.88 High High
Rheumatoid Arthritis 100 90.16 High High
Vasculitis 60 85.96 High High
INFLAMMATION 7 68.08 Quite High
Keloid Scars 1 53.64 Quite High
Fibrosis 1 53.12 Quite High
Low Back Pain 56 50.00 Quite Low
Glomerulonephritis 10 48.52 Quite Low
Apoptosis 6 43.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ANCA are specific for the serine protease PR3 or for MPO, both of which are constituents of azurophilic neutrophil granules and monocyte lysosomes.
MPO Binding (specific) of ANCA in monocyte associated with urological neuroanatomy
1) Confidence 0.16 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2893757 Disease Relevance 0.96 Pain Relevance 0.17
Positive sera were further tested for reactivity against myeloperoxidase and proteinase 3 by using an ELISA with an anti-human IgG (H+L) conjugate (Bioadvance, Emerainville, France).
myeloperoxidase Binding (reactivity) of proteinase 3
2) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064868 Disease Relevance 0.22 Pain Relevance 0.21

General Comments

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