INT181870

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.70
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (THPO) extracellular space (THPO) extracellular region (THPO)
Anatomy Link Frequency
platelet 3
liver 1
THPO (Homo sapiens)
Pain Link Frequency Relevance Heat
Infliximab 81 94.16 High High
rheumatoid arthritis 96 92.64 High High
spinal inflammation 55 92.48 High High
methotrexate 9 76.48 Quite High
cva 15 5.00 Very Low Very Low Very Low
fibrosis 15 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
headache 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 2 99.52 Very High Very High Very High
Thrombocytopenia 144 97.16 Very High Very High Very High
Rheumatoid Arthritis 96 92.64 High High
Low Back Pain 55 92.48 High High
Heart Rate Under Development 5 92.40 High High
Syndrome 5 80.32 Quite High
Systemic Lupus Erythematosus 17 79.76 Quite High
Infection 18 79.48 Quite High
Heparin-induced Thrombocytopenia 6 76.96 Quite High
Thrombosis 5 53.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A 5-day time lag occurred, presumably due to TPO stimulation of early and not late megakaryocyte precursors, with a peak platelet count at 12 to 14 days, a log-linear dose response curve and a return to baseline platelet count by day 28 with no rebound thrombocytopenia.21,22
Localization (stimulation) of TPO in platelet associated with thrombocytopenia
1) Confidence 0.75 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2915538 Disease Relevance 0.37 Pain Relevance 0
During times of normal or increased platelet mass there is increased clearance of TPO leading to normalization of TPO levels.19,20

First-generation recombinant thrombopoietin

Localization (clearance) of TPO in platelet
2) Confidence 0.75 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2915538 Disease Relevance 0.10 Pain Relevance 0
During times of normal or increased platelet mass there is increased clearance of TPO leading to normalization of TPO levels.19,20

First-generation recombinant thrombopoietin

Localization (normalization) of TPO in platelet
3) Confidence 0.75 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2915538 Disease Relevance 0.10 Pain Relevance 0
Occurrence of TPO, TG, AMA, LKM, SMA, ADA and ANCA autoantibodies
Localization (Occurrence) of TPO
4) Confidence 0.32 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064868 Disease Relevance 1.95 Pain Relevance 1.39
Following liver trauma, CPP and CO as well as NIRS and TCD values decreased continuously.
Localization (decreased) of NIRS in liver associated with injury
5) Confidence 0.00 Published 2006 Journal Crit Care Section Body Doc Link PMC1550846 Disease Relevance 0.19 Pain Relevance 0

General Comments

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