INT181880

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Context Info
Confidence 0.66
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 21.19
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoa1) extracellular space (Apoa1) extracellular region (Apoa1)
nucleus (Apoa1) enzyme binding (Apoa1)
Anatomy Link Frequency
plasma 4
synovial fluid 3
plaque 1
Apoa1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 152 99.68 Very High Very High Very High
alcohol 77 99.40 Very High Very High Very High
Inflammation 229 99.10 Very High Very High Very High
cytokine 61 81.04 Quite High
Bile 105 80.80 Quite High
agonist 111 74.48 Quite High
chemokine 15 58.56 Quite High
Arthritis 19 51.60 Quite High
psoriasis 126 50.00 Quite Low
Nicotine 6 44.32 Quite Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 2256 100.00 Very High Very High Very High
Rheumatoid Arthritis 154 99.68 Very High Very High Very High
Hyperlipidemia 37 99.24 Very High Very High Very High
INFLAMMATION 248 99.10 Very High Very High Very High
Disease 161 99.08 Very High Very High Very High
Targeted Disruption 97 98.70 Very High Very High Very High
Myocardial Infarction 131 98.12 Very High Very High Very High
Death 45 97.08 Very High Very High Very High
Stroke 18 97.08 Very High Very High Very High
Psoriasis 212 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, apoA-I levels were increased in the synovial fluid of patients with RA [9], although these were still only one-tenth those in plasma.
Positive_regulation (increased) of apoA-I in synovial fluid associated with rheumatoid arthritis
1) Confidence 0.66 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064871 Disease Relevance 1.19 Pain Relevance 0.36
The elevation of apoA-I levels in the synovial fluid of untreated patients with RA was accompanied by increased cholesterol levels, suggesting infiltration of HDL particles in the inflamed joint.
Positive_regulation (elevation) of apoA-I in synovial fluid associated with rheumatoid arthritis and disorder of lipid metabolism
2) Confidence 0.66 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064871 Disease Relevance 1.28 Pain Relevance 0.41
In RA, the levels of circulating apoA-I and HDL cholesterol in untreated patients are lower than in normal controls [6-8].
Positive_regulation (circulating) of apoA-I associated with rheumatoid arthritis and disorder of lipid metabolism
3) Confidence 0.48 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064871 Disease Relevance 1.20 Pain Relevance 0.36
The elevation of apoA-I levels in synovial fluid of RA patients correlated with a rise in cholesterol, suggesting infiltration of HDL particles into the inflamed joint.
Positive_regulation (elevation) of apoA-I in synovial fluid associated with rheumatoid arthritis and disorder of lipid metabolism
4) Confidence 0.44 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064871 Disease Relevance 1.25 Pain Relevance 0.38
The absence of A-SAA suggests that it is unlikely to restrict the inhibitory activity of apoA-I in the contact-mediated induction of IL-1?
Positive_regulation (restrict) of apoA-I
5) Confidence 0.44 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064871 Disease Relevance 0.37 Pain Relevance 0.13
Significantly greater increases in HDL-C and Apo AI with simvastatin compared to atorvastatin (HDL-C: 9% vs 7% p < 0.001; Apo AI: 6% vs 3%, p < 0.001) were observed (Kastelein et al 2000).
Positive_regulation (increases) of Apo AI associated with disorder of lipid metabolism
6) Confidence 0.30 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.89 Pain Relevance 0
While measuring HDL-C subfractions are not recommended at present, recent data suggests that increased Apo AI plasma levels and Apo AI:Apo B ratios correlate with a reduced risk of myocardial infarction and stroke (Qureshi et al 2002).
Positive_regulation (increased) of Apo AI in plasma associated with stroke, myocardial infarction and disorder of lipid metabolism
7) Confidence 0.30 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.44 Pain Relevance 0.08
The level of apoA1 increases also in familiar hyperproteinemia, in pregnancy, during estrogen therapy, and during physical exercise.
Positive_regulation (increases) of apoA1
8) Confidence 0.24 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.18 Pain Relevance 0.05
In most studies, elevated levels of apoA1, apoB [16, 43], apoC3, and apoE [41, 76–78] were detected in the serum of psoriatic patients compared to the healthy control group.
Positive_regulation (elevated) of apoA1 associated with psoriasis
9) Confidence 0.24 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.08 Pain Relevance 0.03
Conversely, over expression of human LCAT in transgenic animal models correlates with a 7-fold increase in serum HDL-C, increases in Apo AI levels, and a marked reduction in atheromatous plaque burden (Francone et al 1990).
Positive_regulation (increases) of Apo AI in plaque associated with targeted disruption and disorder of lipid metabolism
10) Confidence 0.20 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.66 Pain Relevance 0.03
Niacin raises HDL-C levels by reducing the fractional catabolic rate of Apo AI containing HDL-C particles, decreasing hepatic removal of lipoprotein A-I (LpA-I) (a cardioprotective subfraction of HDL-C without Apo AII), and inhibiting removal of Apo AI without affecting HDL cholesterol ester (Jin et al 1997); resulting in an increase of Apo AI enriched, pre-?
Positive_regulation (increase) of Apo AI associated with disorder of lipid metabolism
11) Confidence 0.20 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.62 Pain Relevance 0
While measuring HDL-C subfractions are not recommended at present, recent data suggests that increased Apo AI plasma levels and Apo AI:Apo B ratios correlate with a reduced risk of myocardial infarction and stroke (Qureshi et al 2002).
Positive_regulation (increased) of Apo AI in plasma associated with stroke, myocardial infarction and disorder of lipid metabolism
12) Confidence 0.20 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.39 Pain Relevance 0.08
At the highest dosing regimen, Apo AI and Apo E increased by 27% and 66% respectively, while Apo B decreased by 26% (Clark et al 2004).
Positive_regulation (increased) of Apo AI
13) Confidence 0.20 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.65 Pain Relevance 0
ApoA-I binding to the scavenger receptor-BI (SR-B1) is required for HDL activation of eNOS (Yuhanna et al 2001); however, eNOS is not activated by lipid-free ApoA-I.
Neg (not) Positive_regulation (activated) of ApoA-I associated with disorder of lipid metabolism
14) Confidence 0.19 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.15 Pain Relevance 0.11
ApoA-I binding to the scavenger receptor-BI (SR-B1) is required for HDL activation of eNOS (Yuhanna et al 2001); however, eNOS is not activated by lipid-free ApoA-I.
Positive_regulation (required) of ApoA-I associated with disorder of lipid metabolism
15) Confidence 0.19 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.15 Pain Relevance 0.12
Thus, it seems that weakening of the cytotoxic effect of Ox-LDL in the presence of HDL or ApoA-I is related to the expression of still unknown factors that prevent cell death.
Positive_regulation (presence) of ApoA-I associated with death and disorder of lipid metabolism
16) Confidence 0.19 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.87 Pain Relevance 0
Induction of CYP3A by some SXR ligands was positively correlated with induction of ApoA-I mRNA and plasma HDL and ApoA-I levels in mice [Bachmann et al., 2004].
Positive_regulation (induction) of ApoA-I in plasma associated with disorder of lipid metabolism
17) Confidence 0.14 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.32 Pain Relevance 0.03
Our study reveals an increase in ApoA-I level in pulmonary tissue after treatment with doxycycline.
Positive_regulation (increase) of ApoA-I
18) Confidence 0.11 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2824689 Disease Relevance 0.53 Pain Relevance 0.10
Since ApoA-I overexpression has been demonstrated to play a protective role in lipopolisacharide (LPS) induced systemic inflammation and multiple organ damage in mice [32], the increase in ApoA-I level, which we observed, can thus play an important role in limitation of VILI as well.
Positive_regulation (increase) of ApoA-I associated with lung injury and inflammation
19) Confidence 0.11 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2824689 Disease Relevance 0.55 Pain Relevance 0.13
Induction of CYP3A by some SXR ligands was positively correlated with induction of ApoA-I mRNA and plasma HDL and ApoA-I levels in mice [Bachmann et al., 2004].
Positive_regulation (induction) of ApoA-I in plasma associated with disorder of lipid metabolism
20) Confidence 0.10 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.33 Pain Relevance 0.04

General Comments

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