INT181881

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Context Info
Confidence 0.48
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 14.31
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoa1) extracellular space (Apoa1) extracellular region (Apoa1)
nucleus (Apoa1) enzyme binding (Apoa1)
Anatomy Link Frequency
plasma 4
synovial fluid 2
plaque 2
endothelium 2
Apoa1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 124 100.00 Very High Very High Very High
Inflammation 118 100.00 Very High Very High Very High
rheumatoid arthritis 60 99.12 Very High Very High Very High
Bile 29 98.84 Very High Very High Very High
cytokine 39 81.04 Quite High
Potency 7 59.20 Quite High
imagery 9 43.32 Quite Low
alcohol 79 5.00 Very Low Very Low Very Low
Angina 22 5.00 Very Low Very Low Very Low
cINOD 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 2181 100.00 Very High Very High Very High
INFLAMMATION 125 100.00 Very High Very High Very High
Repression 8 100.00 Very High Very High Very High
Rheumatoid Arthritis 66 99.12 Very High Very High Very High
Disease 68 98.80 Very High Very High Very High
Targeted Disruption 77 98.70 Very High Very High Very High
Myocardial Infarction 136 98.12 Very High Very High Very High
Stroke 14 97.08 Very High Very High Very High
Lung Injury 76 96.96 Very High Very High Very High
Atherosclerosis 353 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies suggest that variations of apoA-I levels may inversely correlate with disease activity.
Positive_regulation (variations) of Gene_expression (levels) of apoA-I associated with disease
1) Confidence 0.48 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064871 Disease Relevance 1.20 Pain Relevance 0.38
The elevation of apoA-I levels in synovial fluid of RA patients correlated with a rise in cholesterol, suggesting infiltration of HDL particles into the inflamed joint.
Positive_regulation (elevation) of Gene_expression (levels) of apoA-I in synovial fluid associated with rheumatoid arthritis and disorder of lipid metabolism
2) Confidence 0.48 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064871 Disease Relevance 1.26 Pain Relevance 0.38
Conversely, over expression of human LCAT in transgenic animal models correlates with a 7-fold increase in serum HDL-C, increases in Apo AI levels, and a marked reduction in atheromatous plaque burden (Francone et al 1990).
Positive_regulation (increases) of Gene_expression (levels) of Apo AI in plaque associated with targeted disruption and disorder of lipid metabolism
3) Confidence 0.22 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.66 Pain Relevance 0.03
While measuring HDL-C subfractions are not recommended at present, recent data suggests that increased Apo AI plasma levels and Apo AI:Apo B ratios correlate with a reduced risk of myocardial infarction and stroke (Qureshi et al 2002).
Positive_regulation (increased) of Gene_expression (levels) of Apo AI in plasma associated with stroke, myocardial infarction and disorder of lipid metabolism
4) Confidence 0.22 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.39 Pain Relevance 0.08
and by enhancing expression of Apo AI and AII, LL, and ABCA1, which collectively enhance RCT (Tilly-Kiesi et al 1992).
Positive_regulation (enhancing) of Gene_expression (expression) of Apo AI
5) Confidence 0.22 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.10 Pain Relevance 0.03
Emerging therapies such as Apo AI mimetics (Eriksson et al 1999) and LXR agonists (Plosch et al 2002) increase fecal sterol excretion (FSE), while CETP inhibition with torcetrapib fails to affect fecal sterol content (Brousseau et al 2005).
Positive_regulation (increase) of Gene_expression (mimetics) of Apo AI associated with agonist
6) Confidence 0.22 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.22 Pain Relevance 0.10
While measuring HDL-C subfractions are not recommended at present, recent data suggests that increased Apo AI plasma levels and Apo AI:Apo B ratios correlate with a reduced risk of myocardial infarction and stroke (Qureshi et al 2002).
Positive_regulation (increased) of Gene_expression (levels) of Apo AI in plasma associated with stroke, myocardial infarction and disorder of lipid metabolism
7) Confidence 0.22 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.44 Pain Relevance 0.08
Exogenous HDL-C or Apo AI administration also enhance fecal steroid excretion, increase serum pre-?
Positive_regulation (-) of Gene_expression (administration) of Apo AI associated with disorder of lipid metabolism
8) Confidence 0.22 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.84 Pain Relevance 0
Some studies suggest increased HDL-C results from a decreased fractional catabolic rate of Apo AI and an increased production of Apo AI induced by inhibiting HMG-Co A reductase (Schaefer et al 1999).
Positive_regulation (increased) of Gene_expression (production) of Apo AI associated with disorder of lipid metabolism
9) Confidence 0.20 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.86 Pain Relevance 0
The PI3K/Akt pathway has been implicated in many of the effects of HDL on the endothelium; furthermore, mice overexpressing ApoA-I present an increased Akt phosphorylation in the arterial wall (Norata et al 2005) and mice lacking one of the lysosphingolipid receptors show a reduced Akt phosphorylation in the arterial wall (Nofer et al 2004).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of ApoA-I in endothelium associated with disorder of lipid metabolism
10) Confidence 0.17 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.11 Pain Relevance 0.07
Since ApoA-I overexpression has been demonstrated to play a protective role in lipopolisacharide (LPS) induced systemic inflammation and multiple organ damage in mice [32], the increase in ApoA-I level, which we observed, can thus play an important role in limitation of VILI as well.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ApoA-I associated with lung injury and inflammation
11) Confidence 0.11 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2824689 Disease Relevance 0.57 Pain Relevance 0.12
case of rat, this induction leads to the repression of the ApoA-I gene
Positive_regulation (leads) of Gene_expression (repression) of ApoA-I gene associated with repression
12) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.25 Pain Relevance 0.03
increases the expressions of ApoA-I and
Positive_regulation (increases) of Gene_expression (expressions) of ApoA-I
13) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.72 Pain Relevance 0.03
Since ApoA-I overexpression has been demonstrated to play a protective role in lipopolisacharide (LPS) induced systemic inflammation and multiple organ damage in mice [32], the increase in ApoA-I level, which we observed, can thus play an important role in limitation of VILI as well.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ApoA-I associated with lung injury and inflammation
14) Confidence 0.08 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2824689 Disease Relevance 0.62 Pain Relevance 0.13

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