INT181882

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Context Info
Confidence 0.71
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 7.94
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoa1) extracellular space (Apoa1) extracellular region (Apoa1)
nucleus (Apoa1) enzyme binding (Apoa1)
Anatomy Link Frequency
T cells 2
Apoa1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 78 99.68 Very High Very High Very High
cytokine 23 96.28 Very High Very High Very High
rheumatoid arthritis 120 90.56 High High
agonist 55 57.08 Quite High
Arthritis 12 38.88 Quite Low
Bile 13 30.08 Quite Low
alcohol 27 5.00 Very Low Very Low Very Low
Angina 10 5.00 Very Low Very Low Very Low
aspirin 9 5.00 Very Low Very Low Very Low
methotrexate 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 80 99.68 Very High Very High Very High
Coronary Artery Disease 24 99.24 Very High Very High Very High
Disease 72 98.72 Very High Very High Very High
Atherosclerosis 154 97.96 Very High Very High Very High
Disorder Of Lipid Metabolism 1090 97.56 Very High Very High Very High
Rheumatoid Arthritis 120 90.56 High High
Hypertriglyceridemia 56 89.72 High High
Metabolic Syndrome 15 74.96 Quite High
Obesity 6 73.36 Quite High
Apoptosis 10 71.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observation that apoA-I can infiltrate and be retained at the inflammatory site suggests that apoA-I may inhibit the local triggering of IL-1?
Localization (infiltrate) of apoA-I associated with inflammation
1) Confidence 0.71 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064871 Disease Relevance 1.15 Pain Relevance 0.37
The observation that apoA-I can infiltrate and be retained at the inflammatory site suggests that apoA-I may inhibit the local triggering of IL-1?
Localization (retained) of apoA-I associated with inflammation
2) Confidence 0.71 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064871 Disease Relevance 1.15 Pain Relevance 0.37
The perivascular localization of apoA-I suggests that it could have an inhibitory role in zones where T lymphocytes are in close contact with monocyte–macrophages, with a tendency to form 'lymphoid microstructures' [12].
Localization (localization) of apoA-I in T lymphocytes
3) Confidence 0.67 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064871 Disease Relevance 0.06 Pain Relevance 0.03
In conclusion, the localization of apoA-I in inflamed synovium suggests that it can locally inhibit the production of proinflammatory cytokines by monocyte–macrophages upon direct contact with stimulated T cells.
Localization (localization) of apoA-I in T cells associated with cytokine
4) Confidence 0.67 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064871 Disease Relevance 1.02 Pain Relevance 0.38
Exogenous administration of Apo AI and Apo AI mimetics
Localization (administration) of Apo AI
5) Confidence 0.32 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.81 Pain Relevance 0.09
Exogenous administration of Apo AI and Apo AI mimetics
Localization (administration) of Apo AI
6) Confidence 0.32 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.81 Pain Relevance 0.09
The ABCA-1 receptor molecule is responsible for lipidating only newly secreted apoA-1, while the ABCG-1 and SR-B1 receptors can directly lipidate HDL molecule.
Localization (secreted) of apoA-1 associated with disorder of lipid metabolism
7) Confidence 0.16 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.76 Pain Relevance 0
Second, ApoA-1 and ApoB were not measured at the baseline; however, Ingelsson et al in a large population based study highlighted that the overall performance of ApoB/ApoA-1 for prediction of CHD was comparable with that of traditional lipid ratios, and did not result in incremental utility over TC/HDL-C [37].
Localization (performance) of ApoA-1 associated with coronary artery disease and disorder of lipid metabolism
8) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2835707 Disease Relevance 2.17 Pain Relevance 0.04

General Comments

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