INT181888

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Context Info
Confidence 0.26
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 5.07
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoa1) extracellular space (Apoa1) extracellular region (Apoa1)
nucleus (Apoa1) enzyme binding (Apoa1)
Anatomy Link Frequency
bile 1
Apoa1 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 44 100.00 Very High Very High Very High
ischemia 2 96.60 Very High Very High Very High
cytokine 14 95.56 Very High Very High Very High
Inflammation 67 89.56 High High
chemokine 4 64.40 Quite High
agonist 34 63.84 Quite High
psoriasis 63 54.16 Quite High
rheumatoid arthritis 31 51.44 Quite High
alcohol 15 44.12 Quite Low
cINOD 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 473 100.00 Very High Very High Very High
Disease 47 99.24 Very High Very High Very High
Psoriasis 106 98.68 Very High Very High Very High
Acute Coronary Syndrome 3 98.44 Very High Very High Very High
Cv Unclassified Under Development 1 96.60 Very High Very High Very High
Targeted Disruption 31 96.40 Very High Very High Very High
Reperfusion Injury 2 96.24 Very High Very High Very High
Repression 7 95.64 Very High Very High Very High
INFLAMMATION 73 89.56 High High
Hyperlipidemia 13 88.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The alterations in apoA-I infiltration may also explain fluctuations of disease activity.
Regulation (alterations) of apoA-I associated with disease
1) Confidence 0.26 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064871 Disease Relevance 0.76 Pain Relevance 0.27
Many authors did not show any differences in apoA1, apoA2, and apoB levels between psoriatic patients and the control group [10, 76, 80].
Neg (not) Regulation (differences) of apoA1 associated with psoriasis
2) Confidence 0.23 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.21 Pain Relevance 0.03
This rapid elevation of HDL-C levels suggests a possible future role for Apo AI mimetic peptides in the management of acute coronary syndromes or in the setting of ischemia-reperfusion injury (Marchesi et al 2004).
Spec (possible) Regulation (role) of Apo AI associated with acute coronary syndrome, reperfusion injury, ischemia and disorder of lipid metabolism
3) Confidence 0.19 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.16 Pain Relevance 0.08
Both ApoA-I and the lysosphingolipids SPC, LSF, and sphingosine 1-phosphate present in the HDL are responsible for intracellular signaling activation.
Regulation (responsible) of ApoA-I associated with disorder of lipid metabolism
4) Confidence 0.10 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.20 Pain Relevance 0.13
response element in the human ApoA-I
Regulation (response) of ApoA-I
5) Confidence 0.09 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.25 Pain Relevance 0.03
Another study showed that the inhibitory effects of bile acids on HDL and ApoA-I levels were much more pronounced in SXR null mice, whereas these effects were blocked in transgenic humanized mice [Masson et al., 2005].
Regulation (effects) of ApoA-I in bile associated with targeted disruption, bile and disorder of lipid metabolism
6) Confidence 0.06 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.49 Pain Relevance 0.05

General Comments

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