INT181895

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Context Info
Confidence 0.03
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.78
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ROS1, HIF1A) cell proliferation (ROS1) signal transduction (HIF1A)
nucleolus (HIF1A) nucleus (HIF1A) plasma membrane (ROS1)
ROS1 (Homo sapiens)
HIF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 15 86.16 High High
rheumatoid arthritis 68 82.72 Quite High
cytokine 8 72.00 Quite High
Inflammation 22 5.00 Very Low Very Low Very Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 58 100.00 Very High Very High Very High
Experimental Arthritis 2 86.16 High High
Synovitis 17 84.32 Quite High
Rheumatoid Arthritis 68 82.72 Quite High
Cancer 21 5.00 Very Low Very Low Very Low
Stress 19 5.00 Very Low Very Low Very Low
INFLAMMATION 17 5.00 Very Low Very Low Very Low
Arthritis 13 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An alternative hypothesis suggests that ROS are in fact produced by mitochondria during hypoxia and may indeed serve to stabilize HIF-1?
ROS Positive_regulation (stabilize) of HIF-1 associated with hypoxia
1) Confidence 0.03 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 0.78 Pain Relevance 0.15

General Comments

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