INT18190

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Context Info
Confidence 0.60
First Reported 1990
Last Reported 2010
Negated 3
Speculated 4
Reported most in Body
Documents 11
Total Number 15
Disease Relevance 9.01
Pain Relevance 7.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (DRD2) plasma membrane (DRD2) signal transducer activity (DRD2)
Anatomy Link Frequency
striatum 3
brain 1
pupil 1
basal ganglia 1
T cell 1
DRD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 663 100.00 Very High Very High Very High
dopamine receptor 43 100.00 Very High Very High Very High
Pain 107 99.96 Very High Very High Very High
antagonist 25 99.96 Very High Very High Very High
Serotonin 98 99.92 Very High Very High Very High
antidepressant 9 99.64 Very High Very High Very High
Fibrositis 94 98.60 Very High Very High Very High
Lasting pain 3 98.56 Very High Very High Very High
agonist 50 98.16 Very High Very High Very High
drug abuse 37 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 113 99.96 Very High Very High Very High
Tourette's Syndrome 53 99.84 Very High Very High Very High
Impulse Control Disorders 11 99.84 Very High Very High Very High
Fibromyalgia 94 98.60 Very High Very High Very High
Disease 106 98.12 Very High Very High Very High
Substance Abuse 67 97.88 Very High Very High Very High
Schizophrenia 9 97.60 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1219 96.52 Very High Very High Very High
Drug Dependence 21 96.16 Very High Very High Very High
Anxiety Disorder 43 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Postsynaptic D2-dopamine receptors (D2Rs) either are not affected or are increased in the striatum of untreated PD patients (Antonini et al. 1994; Brooks et al. 1992; Rinne et al. 1990).
Neg (not) Regulation (affected) of D2R in striatum associated with dopamine receptor and disease
1) Confidence 0.60 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.80 Pain Relevance 0.69
No alteration of D2 dopamine receptors in the major basal ganglia were found in drug naive schizophrenic patients.
Neg (No) Regulation (alteration) of D2 dopamine in basal ganglia associated with dopamine receptor and schizophrenia
2) Confidence 0.56 Published 1990 Journal Acta Radiol Suppl Section Abstract Doc Link 1966956 Disease Relevance 0.10 Pain Relevance 0.54
The effect of dopamine D2 receptor antagonists, such as chlorpromazine and haloperidol, on pupil size in awake subjects suggests that these drugs might also alter pupillary reflex dilation and pupil size during general anesthesia.
Regulation (effect) of dopamine D2 receptor in pupil associated with anesthesia, dopamine and antagonist
3) Confidence 0.44 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 14633536 Disease Relevance 0.07 Pain Relevance 0.46
With this said we must consider these results with caution, especially in terms of in vivo studies by Chen et al [63] showing a down-regulation of D2 receptor density following a 6 day infusion of the D2 agonist quinpirole [64].
Regulation (regulation) of D2 receptor associated with agonist
4) Confidence 0.44 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2615745 Disease Relevance 0.99 Pain Relevance 0.38
Taken together, these results suggest that the down-regulation of D2 dopamine receptor and D2 receptor messenger RNA is the result of the persistent stimulation of D2 receptors and that the up-regulation of mu opioid receptors may be a compensatory response to a decreased biosynthesis of enkephalin.
Regulation (regulation) of D2 receptor associated with dopamine receptor, mu opioid receptor and enkephalin
5) Confidence 0.44 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2615745 Disease Relevance 0.12 Pain Relevance 0.53
Using radioligand binding assays and post-mortem normal human brain tissue, we obtained equilibrium dissociation constants (Kds) for 17 antidepressants and two of their metabolites at histamine H1, muscarinic, alpha 1-adrenergic, alpha 2-adrenergic, dopamine D2, serotonin 5-HT1A, and serotonin 5-HT2 receptors.
Regulation (metabolites) of dopamine D2 in brain associated with dopamine, antidepressant and serotonin
6) Confidence 0.41 Published 1994 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7855217 Disease Relevance 0 Pain Relevance 0.49
These results suggest that genetic variants at the DRD2 gene play a role in pathological gambling and support the concept that variants of this gene are a risk factor for impulsive and addictive behaviors 49
Regulation (role) of DRD2 associated with impulse control disorders
7) Confidence 0.39 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1352384 Disease Relevance 1.01 Pain Relevance 0.21
Due to complicated interactions not only within monoamine neurotransmitter systems but also with related other enzymes and other pain modulating systems, it is not clear whether genetic polymorphisms in DRD2 affect pain sensitivity.
Neg (not) Spec (whether) Regulation (affect) of DRD2 associated with pain, neurotransmitter and monoamine
8) Confidence 0.37 Published 2006 Journal Mol Pain Section Body Doc Link PMC1543620 Disease Relevance 0.80 Pain Relevance 0.72
We propose that the striatal dopamine D2 receptor may be an important target for the diagnosis and treatment of chronic pain.
Regulation (target) of dopamine D2 receptor associated with dopamine and lasting pain
9) Confidence 0.27 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464032 Disease Relevance 0.60 Pain Relevance 1.02
In addition, the two polymorphisms appear to functionally influence the dopamine D2 and D4 receptors, which are densely located in the corticostriatal-mesolimbic system [80-87], the apparent neurobiological substrate and neurotransmitter system underlying delay discounting [59-61,73-75].
Spec (appear) Regulation (influence) of dopamine D2 associated with neurotransmitter and dopamine
10) Confidence 0.26 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1781951 Disease Relevance 0.75 Pain Relevance 0.18
Finally, we suggest that the reported changes in the D3 and D2 receptor RNA levels in peripheral blood lymphocytes of individuals with schizophrenia, Parkinson's disease, Alzheimer's disease and migraine can serve not only as a 'passive' diagnostic marker, but primarily reflect the dynamic functional dopamine-T cell interactions in these diseases.
Regulation (changes) of D2 receptor RNA in T cell associated with dopamine, migraine, disease and schizophrenia
11) Confidence 0.22 Published 2001 Journal Eur. J. Immunol. Section Abstract Doc Link 11745370 Disease Relevance 0.58 Pain Relevance 0.87
These findings are interesting since altered dopamine D2 receptor function has been demonstrated in FMS patients [26] and recent evidence has demonstrated the efficacy of a dopamine-3 agonist, pramipexole, in patients with FMS [27].
Regulation (altered) of dopamine D2 receptor associated with dopamine, agonist and fibrositis
12) Confidence 0.12 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779444 Disease Relevance 1.55 Pain Relevance 0.90
In addition, at 2 and 8 months of treatment, the investigators measured dopamine D2 receptor (D2R) availability in the striatum using [(11)C]raclopride microPET (muPET) imaging.
Spec (investigators) Regulation (measured) of dopamine D2 receptor in striatum associated with dopamine and imagery
13) Confidence 0.11 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 0.41 Pain Relevance 0.23
In addition, at 2 and 8 months of treatment, the investigators measured dopamine D2 receptor (D2R) availability in the striatum using [(11)C]raclopride microPET (muPET) imaging.
Spec (investigators) Regulation (measured) of D2R in striatum associated with dopamine and imagery
14) Confidence 0.11 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 0.41 Pain Relevance 0.23
An indication of the importance of the dopamine D2 receptor in Tourette syndrome comes from SPECT (single photon emission computed tomography) studies of monozygotic twins discordant for tic severity.
Regulation (importance) of dopamine D2 receptor associated with tourette's syndrome, dopamine and tics
15) Confidence 0.06 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 0.83 Pain Relevance 0.18

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