INT18191

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 1986
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 48
Total Number 48
Disease Relevance 10.21
Pain Relevance 13.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cyp3a23/3a1) endoplasmic reticulum (Cyp3a23/3a1)
Anatomy Link Frequency
liver 8
hepatocyte 2
ileum 1
nucleus 1
DLF 1
Cyp3a23/3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 313 100.00 Very High Very High Very High
narcan 12 100.00 Very High Very High Very High
qutenza 9 99.84 Very High Very High Very High
fluoxetine 36 99.68 Very High Very High Very High
diclofenac 5 99.60 Very High Very High Very High
Calcitonin gene-related peptide 33 99.56 Very High Very High Very High
Paracetamol 36 99.40 Very High Very High Very High
cocaine 8 98.64 Very High Very High Very High
Potency 9 97.72 Very High Very High Very High
Inflammation 22 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Overactive Bladder 1 100.00 Very High Very High Very High
Abnormal Reflex 1 100.00 Very High Very High Very High
Adenovirus Infection 28 99.68 Very High Very High Very High
Targeted Disruption 9 99.68 Very High Very High Very High
Primary Sclerosing Cholangitis 6 99.44 Very High Very High Very High
Rheumatoid Arthritis 256 99.12 Very High Very High Very High
Hepatotoxicity 24 99.08 Very High Very High Very High
Adverse Drug Reaction 4 97.76 Very High Very High Very High
INFLAMMATION 25 97.64 Very High Very High Very High
Infection 41 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition of cytochrome P450 (CYP)-mediated substrate oxidations by alkylamine-based drugs was investigated in rat hepatic microsomes.
Negative_regulation (inhibition) of CYP
1) Confidence 0.57 Published 2003 Journal Xenobiotica Section Abstract Doc Link 14555335 Disease Relevance 0 Pain Relevance 0.36
Mechanism-based inhibition of CYP activities in rat liver by fluoxetine and structurally similar alkylamines.
Negative_regulation (inhibition) of CYP in liver associated with fluoxetine
2) Confidence 0.57 Published 2003 Journal Xenobiotica Section Title Doc Link 14555335 Disease Relevance 0 Pain Relevance 0.60
In contrast, with the exception of SKF-525-A, tertiary alkylamines (10 compounds) inhibited specific CYP activities but did not form MI complexes.
Negative_regulation (inhibited) of CYP
3) Confidence 0.57 Published 2003 Journal Xenobiotica Section Abstract Doc Link 14555335 Disease Relevance 0 Pain Relevance 0.61
Pre-incubation of these agents with NADPH-supplemented microsomes did not enhance inhibition of CYP activities, thus suggesting that formation of inhibitory metabolites was minimal for these compounds. 4.
Negative_regulation (inhibition) of CYP
4) Confidence 0.57 Published 2003 Journal Xenobiotica Section Abstract Doc Link 14555335 Disease Relevance 0 Pain Relevance 0.57
The rats with protein-calorie malnutrition (PCM, 5% casein diet for a period of 4-week) were reported to exhibit 60 and 80% suppression in the hepatic microsomal cytochrome P450 (CYP) 1A2 and CYP2C11 levels, respectively, and 40-50% decreases in CYP2E1 and CYP3A1/2 levels compared to control (23% casein diet for a period of 4-week) based on Western blot analysis.
Negative_regulation (decreases) of CYP3A1 in 1A2 associated with appetite loss
5) Confidence 0.57 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15356995 Disease Relevance 0.17 Pain Relevance 0
Within 24 h, these changes were accompanied by a rapid decrease in total P450 contents in FCA-treated rat liver and the selective downregulation of specific CYP isoforms, as illustrated by decreased mRNA levels (CYP2B, CYP2CI1, CYP3A1, and CYP2E1), protein contents (CYP2B, CYP2C11, and CYP2E1) or catalytic activities (CYP2C6, CYP2C11, and CYP2E1).
Negative_regulation (downregulation) of CYP in liver
6) Confidence 0.57 Published 2005 Journal Pharm. Res. Section Body Doc Link 15771231 Disease Relevance 0 Pain Relevance 0
The enzyme inactivation was paralleled by a loss of immunoreactive cytochrome P-450 IIIA protein.
Negative_regulation (loss) of P-450 IIIA protein
7) Confidence 0.52 Published 1995 Journal Transplantation Section Abstract Doc Link 7676491 Disease Relevance 0 Pain Relevance 0.09
Other CYP isozyme selective inhibitors, such as metyrapone (CYP 2B), 7-pentoxyresorufin (CYP 2B1), sulfaphenazole (CYP 2C/3A), and 17-octadecynoic acid (4A-linked omega-hydroxylase inhibitor), did not alter ACh or histamine-induced EDHF response.
Negative_regulation (inhibitors) of CYP isozyme
8) Confidence 0.47 Published 1997 Journal Am. J. Hypertens. Section Abstract Doc Link 9234831 Disease Relevance 0.14 Pain Relevance 0.11
The rate of formation of MEGX was decreased, and plasma concentration of bilirubin was elevated postsurgically; this could have been the result of decreased cytochrome P-450IIIA activity or decreased hepatic blood flow after hepatic resection.
Negative_regulation (decreased) of cytochrome P-450IIIA in blood
9) Confidence 0.46 Published 1995 Journal Ther Drug Monit Section Abstract Doc Link 7624913 Disease Relevance 0 Pain Relevance 0.27
These findings suggest that in this patient, hepatic cytochrome P-450IIIA activity was not impaired, but selective impairment of uptake of ICG into hepatocytes or excretion into the bile ducts was present.
Negative_regulation (impaired) of cytochrome P-450IIIA in bile ducts associated with bile
10) Confidence 0.46 Published 1995 Journal Ther Drug Monit Section Abstract Doc Link 7624913 Disease Relevance 0 Pain Relevance 0.31
CYP3A1 mRNA levels were severely decreased by FCA administration, whereas CYP3A2 mRNA and protein levels remained unchanged.
Negative_regulation (decreased) of CYP3A1
11) Confidence 0.46 Published 2005 Journal Pharm. Res. Section Body Doc Link 15771231 Disease Relevance 0 Pain Relevance 0
P-450 IIIA activity was decreased compared with that in controls, including other liver transplant recipients.
Negative_regulation (decreased) of P-450 IIIA in liver
12) Confidence 0.45 Published 1990 Journal Lancet Section Abstract Doc Link 1967328 Disease Relevance 0.16 Pain Relevance 0.09
One alternative explanation is that fluoxetine, by inhibiting cytochrome P450 (CYP) enzymes, interferes with the metabolism of cocaine.
Negative_regulation (inhibiting) of CYP associated with cocaine and fluoxetine
13) Confidence 0.43 Published 2004 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 14740149 Disease Relevance 0 Pain Relevance 0.53
This effect suggests that fluoxetine slows the metabolism of cocaine, perhaps by inhibition of CYP enzymes involved in metabolizing cocaine.
Negative_regulation (inhibition) of CYP
14) Confidence 0.43 Published 2004 Journal Psychopharmacology (Berl.) Section Body Doc Link 14740149 Disease Relevance 0 Pain Relevance 0
Ph, Cyp and Nal, the reduction of FLI neurons on the DLF-intact side were decreased by 27% (p<0.01), 21% (p<0.01), and 25% (p<0.01), respectively; (3) when rats were pretreated with combined i.t.
Negative_regulation (decreased) of Cyp in DLF associated with narcan
15) Confidence 0.43 Published 1999 Journal Brain Res. Section Abstract Doc Link 10350573 Disease Relevance 0.23 Pain Relevance 0.61
TBARS formation in rat liver microsomes was suppressed by diethyldithiocarbamate (a specific inhibitor of cytochrome P450 (CYP)2E1) and diclofenac (a specific inhibitor of CYP2C11).
Negative_regulation (inhibitor) of CYP in liver associated with diclofenac
16) Confidence 0.42 Published 2010 Journal Chem. Biol. Interact. Section Abstract Doc Link 19948161 Disease Relevance 0.61 Pain Relevance 0.18
The level of CYP 2B1 activity was decreased by Kupffer cell inactivation, but not by FFx.
Neg (not) Negative_regulation (decreased) of CYP in Kupffer cell
17) Confidence 0.42 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 12568358 Disease Relevance 0.30 Pain Relevance 0.15
In addition, Northern blot analysis showed that CYP1A2, CYP2E1, CYP2C11, and CYP3A1/2 mRNAs decreased in the state of PCM as well.
Negative_regulation (decreased) of CYP3A1
18) Confidence 0.42 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15356995 Disease Relevance 0.28 Pain Relevance 0
CYP produced a marked detrusor hyperreflexia which was abolished by capsaicin pretreatment.
Negative_regulation (abolished) of CYP associated with qutenza, abnormal reflex and overactive bladder
19) Confidence 0.41 Published 1993 Journal Agents Actions Section Abstract Doc Link 8317316 Disease Relevance 0.37 Pain Relevance 0.73
Hepatic microsomal CYP 450 content and aniline p-hydroxylase (CYP 2E1) activity were significantly decreased; decreases that were not prevented by GdCl3.
Negative_regulation (decreased) of CYP
20) Confidence 0.41 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 12568358 Disease Relevance 0.30 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox