INT181914

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.03
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EGLN1) nucleus (EGLN1) cytoplasm (EGLN1)
EGLN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 68 91.52 High High
Inflammation 24 71.56 Quite High
Arthritis 15 70.80 Quite High
cytokine 10 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Serotonin 5 5.00 Very Low Very Low Very Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 85 99.84 Very High Very High Very High
Hypoxia 67 99.52 Very High Very High Very High
Cancer 26 91.84 High High
Rheumatoid Arthritis 68 91.52 High High
Synovitis 17 91.28 High High
Hypertension 2 81.92 Quite High
Increased Venous Pressure Under Development 3 78.68 Quite High
Experimental Arthritis 2 71.84 Quite High
INFLAMMATION 19 71.56 Quite High
Arthritis 13 61.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reason for the increase in expression of EGLN1 in IPAH is unknown.
Positive_regulation (increase) of EGLN1 associated with pulmonary hypertension
1) Confidence 0.36 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.92 Pain Relevance 0
The biological basis of preconditioning continues to be defined, and might involve signaling by Akt [113] and/or extracellular signal-related kinase 1/2 [114], and possibly an upregulation of PHD-2 during the hypoxic phase [115].
Spec (possibly) Positive_regulation (upregulation) of PHD-2 associated with hypoxia
2) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 1.11 Pain Relevance 0.25

General Comments

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