INT181916

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Context Info
Confidence 0.28
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.72
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ROS1) cell proliferation (ROS1) plasma membrane (ROS1)
Anatomy Link Frequency
liver 2
ROS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 292 98.40 Very High Very High Very High
Arthritis 15 90.40 High High
rheumatoid arthritis 68 86.96 High High
cytokine 29 57.52 Quite High
Inflammation 70 38.44 Quite Low
fibrosis 19 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
Central nervous system 10 5.00 Very Low Very Low Very Low
chemokine 7 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 153 100.00 Very High Very High Very High
Hypoxia 59 99.80 Very High Very High Very High
Death 69 99.52 Very High Very High Very High
Necrosis 15 96.80 Very High Very High Very High
Apoptosis 135 96.32 Very High Very High Very High
Experimental Arthritis 2 90.40 High High
Synovitis 17 88.56 High High
Rheumatoid Arthritis 68 86.96 High High
Toxicity 10 86.44 High High
Cancer 39 75.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
How ROS and other oxidative stress-related reactive intermediates interact with biological macromolecules
Regulation (How) of ROS Binding (interact) of associated with stress
1) Confidence 0.28 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.63 Pain Relevance 0
During hypoxia, reduced ROS formation serves to activate HIF-1?
Regulation (serves) of ROS Binding (formation) of associated with hypoxia
2) Confidence 0.21 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 0.82 Pain Relevance 0.15
The NCTD -induced increase in ROS and antiproliferation in HepG2 cells are apparently dependent on ROS generation, because the NCTD -induced increase in ROS can be
Regulation (dependent) of ROS Binding (generation) of
3) Confidence 0.11 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 0.81 Pain Relevance 0
Notably it has been demonstrated that the cytochrome P450 dependent N-oxidative pathway is responsible for generation of ROS and glutathione (GSH) depletion during cocaine biotransformation in the liver [37].
Regulation (responsible) of ROS Binding (generation) of in liver associated with cocaine
4) Confidence 0.10 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.46 Pain Relevance 0.46

General Comments

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