INT181922

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 20
Disease Relevance 13.92
Pain Relevance 3.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (RENBP)
Anatomy Link Frequency
endothelial cells 3
developmental stage 1
RENBP (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 76 100.00 Very High Very High Very High
Lasting pain 206 99.76 Very High Very High Very High
rheumatoid arthritis 150 99.76 Very High Very High Very High
Arthritis 42 99.30 Very High Very High Very High
Inflammation 146 99.10 Very High Very High Very High
Inflammatory response 5 98.04 Very High Very High Very High
Pain 133 93.28 High High
Fibrositis 14 93.20 High High
Migraine 7 90.96 High High
headache 6 90.24 High High
Disease Link Frequency Relevance Heat
Obesity 325 100.00 Very High Very High Very High
Depression 94 100.00 Very High Very High Very High
Pain 334 99.76 Very High Very High Very High
Rheumatoid Arthritis 150 99.76 Very High Very High Very High
Stress 163 99.62 Very High Very High Very High
Aging 43 99.40 Very High Very High Very High
Arthritis 37 99.30 Very High Very High Very High
Disorder Of Lipid Metabolism 66 99.08 Very High Very High Very High
INFLAMMATION 138 98.04 Very High Very High Very High
Autoimmune Disease 26 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the context of inflammatory arthritis, we have shown that antibodies to AGE-IgG are specifically associated with RA, whereas the actual formation of AGE-IgG is related to the intensity of the systemic inflammatory response, and is not specific to RA [42,43].


AGE Binding (associated) of associated with inflammatory response, inflammation, rheumatoid arthritis and arthritis
1) Confidence 0.36 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 0.78 Pain Relevance 0.35
In the context of inflammatory arthritis, we have shown that antibodies to AGE-IgG are specifically associated with RA, whereas the actual formation of AGE-IgG is related to the intensity of the systemic inflammatory response, and is not specific to RA [42,43].


AGE Binding (formation) of associated with inflammatory response, inflammation, rheumatoid arthritis and arthritis
2) Confidence 0.35 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 0.78 Pain Relevance 0.35
The Cox regression was adjusted for age, gender, HD age, calcium and PTH.
age Binding (gender) of
3) Confidence 0.17 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2903573 Disease Relevance 0.20 Pain Relevance 0
The Cox regression was adjusted for age, gender, HD age, calcium and PTH.
age Binding (gender) of
4) Confidence 0.17 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2903573 Disease Relevance 0.20 Pain Relevance 0
Age, income, depression and functional interference with activities were strongly associated with chronic pain in general.
Age Binding (associated) of associated with depression and lasting pain
5) Confidence 0.17 Published 2004 Journal BMC Womens Health Section Abstract Doc Link PMC2096686 Disease Relevance 0.91 Pain Relevance 0.86
Not surprisingly, chronic pain was also strongly associated with age and multiple chronic conditions.
age Binding (associated) of associated with lasting pain
6) Confidence 0.16 Published 2004 Journal BMC Womens Health Section Body Doc Link PMC2096686 Disease Relevance 1.60 Pain Relevance 1.61
Associations between lead dose and NAG were unchanged, and uric acid was inversely associated with RBP.
RBP Binding (associated) of
7) Confidence 0.10 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1253707 Disease Relevance 0.23 Pain Relevance 0
Affected Trp2 individuals had more severe degeneration, moreover, the association was age-dependent 15, 16.
age Binding (association) of
8) Confidence 0.07 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.51 Pain Relevance 0
The population average ApoB/ApoA1 ratio (BARP) can be estimated from values for the age and gender-adjusted estimates of TC and HDL using the coefficients in Additional file 1, thus:
age Binding (gender) of associated with disorder of lipid metabolism
9) Confidence 0.06 Published 2008 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2601038 Disease Relevance 1.46 Pain Relevance 0
The association between FTO variants and BMI is not in doubt, and has been described both in childhood and old age [11,14-16,54].
age Binding (association) of associated with obesity
10) Confidence 0.05 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2958899 Disease Relevance 0.41 Pain Relevance 0
But does this effect size alter with age?
age Binding (alter) of
11) Confidence 0.05 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2958899 Disease Relevance 0.40 Pain Relevance 0
On the other hand, longitudinal analysis may still identify the relationship, by examining the association of the combination of SNP allele and age with phenotype in aging individuals, through a SNP × age interaction term.
age Spec (examining) Binding (association) of associated with aging
12) Confidence 0.05 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2958899 Disease Relevance 0.38 Pain Relevance 0
On the other hand, longitudinal analysis may still identify the relationship, by examining the association of the combination of SNP allele and age with phenotype in aging individuals, through a SNP × age interaction term.
age Binding (interaction) of associated with aging
13) Confidence 0.05 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2958899 Disease Relevance 0.37 Pain Relevance 0
The influence of genotype on these traits may also vary over time through interaction with factors such as age, developmental stage or time-dependent environmental factors.
age Binding (interaction) of in developmental stage
14) Confidence 0.05 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2958899 Disease Relevance 0.48 Pain Relevance 0
The samples were blinded with only sex and age noted, and stored at ?
age Binding (blinded) of
15) Confidence 0.04 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1253705 Disease Relevance 1.56 Pain Relevance 0.10
Age-modified plasma proteins can bind to AGE receptors (RAGE = AGE-receptor, macrophage scavenger receptor A) on different cell types like endothelial cells, where it can adversely affect the expression of thrombomodulin, tissue factor, and VCAM-1 genes.
AGE Binding (receptor) of in endothelial cells
16) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.56 Pain Relevance 0
Age-modified plasma proteins can bind to AGE receptors (RAGE = AGE-receptor, macrophage scavenger receptor A) on different cell types like endothelial cells, where it can adversely affect the expression of thrombomodulin, tissue factor, and VCAM-1 genes.
AGE Binding (bind) of in endothelial cells
17) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.56 Pain Relevance 0
Age-modified plasma proteins can bind to AGE receptors (RAGE = AGE-receptor, macrophage scavenger receptor A) on different cell types like endothelial cells, where it can adversely affect the expression of thrombomodulin, tissue factor, and VCAM-1 genes.
AGE Binding (bind) of in endothelial cells
18) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.57 Pain Relevance 0
Antibody formations against ox-LDL and AGE-LDL are able to combine with circulating ox-LDL or AGE-modified antigens and form soluble immune complexes that may contribute to inflammation and autoimmunity [44,45].
AGE-LDL Binding (formations) of associated with autoimmune disease and inflammation
19) Confidence 0.01 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2685801 Disease Relevance 0.76 Pain Relevance 0.08
Single marital status and a positive history of depression were found to be significant predictors of the presence of depression, as has been found before.55 Similarly, cortisol did not predict severity of depressive symptoms or perceived stress, and only younger age56 was associated with both of these.
age56 Binding (associated) of associated with stress and depression
20) Confidence 0.00 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938288 Disease Relevance 1.20 Pain Relevance 0.35

General Comments

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