INT181961

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.90
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL7R) extracellular region (IL7R) cell morphogenesis (IL7R)
plasma membrane (IL7R)
Anatomy Link Frequency
B cells 1
IL7R (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 222 97.76 Very High Very High Very High
Multiple sclerosis 225 96.48 Very High Very High Very High
cytokine 202 91.72 High High
Inflammation 185 79.56 Quite High
Kinase C 1 76.16 Quite High
antagonist 4 59.16 Quite High
chemokine 31 56.44 Quite High
tolerance 48 43.80 Quite Low
methotrexate 9 42.20 Quite Low
cINOD 2 41.64 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 226 97.76 Very High Very High Very High
Demyelinating Disease 169 96.48 Very High Very High Very High
Infection 6 81.48 Quite High
Hypersensitivity 7 80.56 Quite High
Inflammatory Bowel Disease 92 80.12 Quite High
Recurrence 22 80.08 Quite High
Autoimmune Disease 92 77.80 Quite High
Death 11 76.68 Quite High
Syndrome 5 74.64 Quite High
Enteropathy 4 73.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, in a cross-sectional comparison of 10 RA patients and 10 healthy control individuals, we could not find a significant difference in the number of cells expressing the IL-7 receptor (CD127) or in its level of expression (data not shown).
Gene_expression (expressing) of CD127 associated with rheumatoid arthritis
1) Confidence 0.75 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.78 Pain Relevance 0.39
Prominent amongst these was the interleukin-7 receptor (IL7R) (Fernald et al., 2005), a gene that had previously been identified as a candidate and studied by groups from Australia (Teutsch et al., 2003) and Sweden (Zhang et al., 2005).
Gene_expression (Prominent) of IL7R
2) Confidence 0.46 Published 2008 Journal Brain Section Body Doc Link PMC2639203 Disease Relevance 0.10 Pain Relevance 0.05
Prominent amongst these was the interleukin-7 receptor (IL7R) (Fernald et al., 2005), a gene that had previously been identified as a candidate and studied by groups from Australia (Teutsch et al., 2003) and Sweden (Zhang et al., 2005).
Gene_expression (Prominent) of interleukin-7 receptor
3) Confidence 0.46 Published 2008 Journal Brain Section Body Doc Link PMC2639203 Disease Relevance 0.10 Pain Relevance 0.05
IL2RA and IL7RA were also searched in silico for potential VDR binding sequences; no putative VDREs were found.


Gene_expression (searched) of IL7RA
4) Confidence 0.44 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2627899 Disease Relevance 0.42 Pain Relevance 0.21
The recent discovery of low expression of CD127 (IL-7 receptor ?)
Gene_expression (expression) of CD127
5) Confidence 0.25 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.19 Pain Relevance 0
0.872, P<0.001), and 74.03% (52.09–89.75) of CD25+CD127?
Gene_expression (0.872) of CD127
6) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001453 Disease Relevance 0.14 Pain Relevance 0
FoxP3 can also interact with the promoter of IL-127 receptor (IL-127R) and might contribute to reduce expression of CD127 in Tregs.
Gene_expression (expression) of CD127
7) Confidence 0.19 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.59 Pain Relevance 0.07
Thus, CD127 expression inversely correlates with FoxP3 expression [21].
Gene_expression (expression) of CD127
8) Confidence 0.19 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.58 Pain Relevance 0.07
Recently, after the description of an inverse relationship between the expression of FoxP3 and CD127 [21], it has become possible to define an alternative phenotype of Tregs as CD3/CD4/CD25high/CD127?
Gene_expression (expression) of CD127
9) Confidence 0.19 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.42 Pain Relevance 0.06
The IL-7R is expressed by circulating CD4+ and CD8+ T-cells, NK-T-cells and monocytes, but not on human B cells.
Gene_expression (expressed) of IL-7R in B cells
10) Confidence 0.01 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 0.59 Pain Relevance 0.40

General Comments

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