INT181962

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.51
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL7) extracellular region (IL7) cell-cell signaling (IL7)
Anatomy Link Frequency
T-cell 2
IL7 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 732 99.84 Very High Very High Very High
cytokine 55 99.44 Very High Very High Very High
Inflammation 42 98.24 Very High Very High Very High
Infliximab 6 57.68 Quite High
Osteoarthritis 12 46.72 Quite Low
cINOD 6 45.36 Quite Low
methotrexate 6 42.32 Quite Low
corticosteroid 6 23.60 Low Low
Multiple sclerosis 6 5.00 Very Low Very Low Very Low
iatrogenic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 733 99.84 Very High Very High Very High
Lymphopenia 105 99.82 Very High Very High Very High
INFLAMMATION 48 98.24 Very High Very High Very High
Increased Venous Pressure Under Development 12 96.36 Very High Very High Very High
Cancer 126 95.20 Very High Very High Very High
Solid Tumor 24 91.32 High High
Malignant Neoplastic Disease 6 81.72 Quite High
Hematological Disease 12 75.32 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 15 64.80 Quite High
Disease 114 59.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, we found that basal serum IL-7 levels were reduced in a range of RA patients, irrespective of inflammation or medication (Fig. 1b).
Negative_regulation (reduced) of Gene_expression (levels) of IL-7 associated with inflammation and rheumatoid arthritis
1) Confidence 0.47 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.93 Pain Relevance 0.22
This is associated with a reduced production of IL-7 in bone marrow derived stromal cell cultures, and may contribute to the defective CD4+ T-cell reconstitution that occurs following therapeutic lymphodepletion, primarily at the level of mature T-cell expansion in the periphery.
Negative_regulation (reduced) of Gene_expression (production) of IL-7 in T-cell
2) Confidence 0.47 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.64 Pain Relevance 0.21
Lymphopenia-induced interleukin-7 production is defective in rheumatoid arthritis
Negative_regulation (defective) of Gene_expression (production) of interleukin-7 associated with lymphopenia and rheumatoid arthritis
3) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.83 Pain Relevance 0.27
Basal interleukin-7 production is reduced in rheumatoid arthritis
Negative_regulation (reduced) of Gene_expression (production) of interleukin-7 associated with rheumatoid arthritis
4) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.67 Pain Relevance 0.34
RA and control PBMCs responded equivalently to IL-7 stimulation in vitro, suggesting no defect in IL-7 receptor expression or signalling (Fig. 1d).
Neg (no) Negative_regulation (defect) of Gene_expression (expression) of IL-7 associated with rheumatoid arthritis
5) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.86 Pain Relevance 0.24
IL-7 expression is upregulated or downregulated by different cytokines in different tissues (transforming growth factor-?
Negative_regulation (downregulated) of Gene_expression (expression) of IL-7 associated with cytokine
6) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.58 Pain Relevance 0.22
TCR diversity spectratype analysis was performed on sorted CD4+ and CD8+ populations before and after (day 21) rhIL-7 therapy in 6 subjects treated at either 30 or 60 ?
Negative_regulation (day) of Gene_expression (therapy) of rhIL-7
7) Confidence 0.26 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0 Pain Relevance 0

General Comments

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