INT181966

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Context Info
Confidence 0.21
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.41
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Prf1) extracellular region (Prf1) cytoplasmic membrane-bounded vesicle (Prf1)
plasma membrane (Prf1) transmembrane transport (Prf1)
Anatomy Link Frequency
NK cells 7
T cells 4
cytotoxic T lymphocytes 3
macrophages 2
Prf1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 315 98.00 Very High Very High Very High
cytokine 32 80.44 Quite High
Inflammation 21 27.04 Quite Low
methotrexate 14 12.80 Low Low
cINOD 7 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 315 98.00 Very High Very High Very High
Hemophagocytic Lymphohistiocytosis 154 95.60 Very High Very High Very High
Macrophage Activation Syndrome 203 90.16 High High
Infection 21 79.28 Quite High
Chronic Myeloid Leukemia 7 72.04 Quite High
Congenital Anomalies 42 68.88 Quite High
Disease 63 67.28 Quite High
Syndrome 21 62.28 Quite High
Lymphadenopathy 7 59.28 Quite High
Exanthema 7 57.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The exact mechanisms that would link deficient NK cell function and, in some cases, depressed perforin expression with the expansion of activated macrophages are not clear.
Negative_regulation (depressed) of Gene_expression (expression) of perforin in macrophages
1) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.43 Pain Relevance 0.13
Because reduced perforin expression in cytotoxic effector cells has previously been reported in sJRA [26,27], we assessed perforin content and relative proportions of perforin-positive NK cells, CD8+ lymphocytes, and NK T cells.
Negative_regulation (reduced) of Gene_expression (expression) of perforin in NK cells
2) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.38 Pain Relevance 0.18
Although no overall correlation between perforin expression and NK cell cytolytic activty was noted in our study, we still cannot exclude the possibility that, at least in some patients, reduced perforin expression might have functional significance.
Negative_regulation (reduced) of Gene_expression (expression) of perforin in NK cell
3) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.78 Pain Relevance 0.11
Because perforin is a protein that mediates the cytotoxic activity of NK cells, we assessed whether decreased perforin expression might have contributed to the development of NK dysfunction in JRA.
Negative_regulation (decreased) of Gene_expression (expression) of perforin in NK cells associated with rheumatoid arthritis
4) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.43 Pain Relevance 0.15
Relative and absolute numbers of NK, CD8+, and NK T cells, as well as perforin and granzyme B expression in these cell populations, were determined as described previously [14,21].
Negative_regulation (numbers) of Gene_expression (expression) of perforin in T cells
5) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.86 Pain Relevance 0.22
Some decrease in perforin expression in NK cells and cytotoxic T lymphocytes was seen in patients within each of the JRA groups with no statistically significant differences.
Negative_regulation (decrease) of Gene_expression (expression) of perforin in cytotoxic T lymphocytes associated with rheumatoid arthritis
6) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064882 Disease Relevance 1.26 Pain Relevance 0.32
Expression of perforin, granzyme B and Foxp3 in CD8+CD94+T cells was minimal
Negative_regulation (minimal) of Gene_expression (Expression) of perforin in T cells
7) Confidence 0.10 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0
Some decrease in perforin expression in NK cells and cytotoxic T lymphocytes was seen in patients within each of the JRA groups with no statistically significant differences.
Negative_regulation (decrease) of in NK cells Gene_expression (expression) of perforin in cytotoxic T lymphocytes associated with rheumatoid arthritis
8) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064882 Disease Relevance 1.26 Pain Relevance 0.32

General Comments

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