INT181968

Context Info Confidence 0.16 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 5 Disease Relevance 4.27 Pain Relevance 0.15

endosome (Prf1) extracellular region (Prf1) cytoplasmic membrane-bounded vesicle (Prf1) plasma membrane (Prf1) transmembrane transport (Prf1)

Anatomy Link Frequency NK cells 2 B cell 1 T cells 1 Prf1 (Mus musculus)

Pain Link Frequency Relevance Heat rheumatoid arthritis 45 98.32 cytokine 59 26.00 Inflammation 58 5.00 peptic ulcer disease 15 5.00 withdrawal 3 5.00 Inflammatory response 3 5.00 chemokine 3 5.00 methotrexate 2 5.00 tolerance 2 5.00 palliative 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 8 99.88 B-cell Lymphoma 9 99.62 Malignant Neoplastic Disease 1 99.52 Rheumatoid Arthritis 45 98.32 Cancer 211 98.24 Autoimmune Disease 42 94.60 Gastritis 171 92.68 Lymphatic System Cancer 63 92.68 Infection 122 89.20 Sprains And Strains 12 87.80

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In the group of seven patients with low perforin levels in NK cells, only three had NK cytolytic activity below 2SD of the control group.

Negative_regulation (levels) of perforin in NK cells

1) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.55 Pain Relevance 0.15

Reinforcing the role of cytotoxic T lymphocytes (CTLs) in the eradication of malignant cells, transgenic mice deficient in perforin, a component of the cytolytic granules of T and NK cells, are more susceptible to spontaneous and chemically induced tumors than their wild type counterparts [5].

Negative_regulation (deficient) of perforin in NK cells associated with targeted disruption, malignant neoplastic disease and cancer

2) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 1.00 Pain Relevance 0

For example, mice that lack perforin, a cytotoxic molecule used by cytotoxic cells such as CD8+?

Negative_regulation (lack) of perforin

3) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896618 Disease Relevance 0.94 Pain Relevance 0

Conversely in a minority of infected patients, H. pylori is able to induce the development of specific T cells defective of both perforin- and Fas ligand-mediated cytotoxicity, which consequently promotes both B-cell overgrowth and exhaustive B-cell proliferation, finally leading to the onset of low-grade gastric MALT lymphoma.

Negative_regulation (defective) of perforin in T cells associated with lymphatic system cancer

4) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896618 Disease Relevance 0.59 Pain Relevance 0

In addition, B cell lymphomas derived from mice lacking both perforin and ?

Negative_regulation (lacking) of perforin in B cell associated with b-cell lymphoma

5) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896618 Disease Relevance 1.19 Pain Relevance 0

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