INT181968

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.16
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 4.27
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Prf1) extracellular region (Prf1) cytoplasmic membrane-bounded vesicle (Prf1)
plasma membrane (Prf1) transmembrane transport (Prf1)
Anatomy Link Frequency
NK cells 2
B cell 1
T cells 1
Prf1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 45 98.32 Very High Very High Very High
cytokine 59 26.00 Quite Low
Inflammation 58 5.00 Very Low Very Low Very Low
peptic ulcer disease 15 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 8 99.88 Very High Very High Very High
B-cell Lymphoma 9 99.62 Very High Very High Very High
Malignant Neoplastic Disease 1 99.52 Very High Very High Very High
Rheumatoid Arthritis 45 98.32 Very High Very High Very High
Cancer 211 98.24 Very High Very High Very High
Autoimmune Disease 42 94.60 High High
Gastritis 171 92.68 High High
Lymphatic System Cancer 63 92.68 High High
Infection 122 89.20 High High
Sprains And Strains 12 87.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the group of seven patients with low perforin levels in NK cells, only three had NK cytolytic activity below 2SD of the control group.
Negative_regulation (levels) of perforin in NK cells
1) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.55 Pain Relevance 0.15
Reinforcing the role of cytotoxic T lymphocytes (CTLs) in the eradication of malignant cells, transgenic mice deficient in perforin, a component of the cytolytic granules of T and NK cells, are more susceptible to spontaneous and chemically induced tumors than their wild type counterparts [5].
Negative_regulation (deficient) of perforin in NK cells associated with targeted disruption, malignant neoplastic disease and cancer
2) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 1.00 Pain Relevance 0
For example, mice that lack perforin, a cytotoxic molecule used by cytotoxic cells such as CD8+?
Negative_regulation (lack) of perforin
3) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896618 Disease Relevance 0.94 Pain Relevance 0
Conversely in a minority of infected patients, H. pylori is able to induce the development of specific T cells defective of both perforin- and Fas ligand-mediated cytotoxicity, which consequently promotes both B-cell overgrowth and exhaustive B-cell proliferation, finally leading to the onset of low-grade gastric MALT lymphoma.



Negative_regulation (defective) of perforin in T cells associated with lymphatic system cancer
4) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896618 Disease Relevance 0.59 Pain Relevance 0
In addition, B cell lymphomas derived from mice lacking both perforin and ?
Negative_regulation (lacking) of perforin in B cell associated with b-cell lymphoma
5) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896618 Disease Relevance 1.19 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox