INT181969

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.62
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Prf1) extracellular region (Prf1) cytoplasmic membrane-bounded vesicle (Prf1)
plasma membrane (Prf1) transmembrane transport (Prf1)
Anatomy Link Frequency
T cells 6
NK cell 4
pore 2
Prf1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 135 100.00 Very High Very High Very High
Central nervous system 56 87.88 High High
nMDA receptor 10 77.24 Quite High
long-term potentiation 11 70.32 Quite High
Calcium channel 8 61.68 Quite High
imagery 12 61.28 Quite High
corticosteroid 98 53.12 Quite High
Inflammation 13 46.68 Quite Low
dexamethasone 3 43.24 Quite Low
cytokine 22 30.64 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 135 100.00 Very High Very High Very High
Hemophagocytic Lymphohistiocytosis 66 98.92 Very High Very High Very High
Macrophage Activation Syndrome 87 96.84 Very High Very High Very High
Disease 34 86.24 High High
Syndrome 16 80.36 Quite High
Systemic Lupus Erythematosus 6 78.12 Quite High
Rheumatic Diseases 15 75.92 Quite High
Sprains And Strains 7 73.84 Quite High
Immunization 7 68.92 Quite High
Death 8 56.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In light of the discrepancy between past and present findings, we further sought to define the importance of perforin expression in promoting vascular permeability and functional impairment by crossing mice heterozygous for perforin (F1) with C57BL/6 Prf1?
Regulation (importance) of Gene_expression (expression) of perforin
1) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516328 Disease Relevance 0 Pain Relevance 0.11
Although no overall correlation between perforin expression and NK cell cytolytic activty was noted in our study, we still cannot exclude the possibility that, at least in some patients, reduced perforin expression might have functional significance.
Neg (no) Regulation (correlation) of Gene_expression (expression) of perforin in NK cell
2) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.82 Pain Relevance 0.11
+), and CD8+ T cells were also assessed for perforin and granzyme B expression by flow cytometry.
Regulation (assessed) of Gene_expression (expression) of perforin in T cells
3) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064882 Disease Relevance 1.40 Pain Relevance 0.31
However, the examination of the individual patterns of perforin staining revealed a small subgroup of JRA patients with a very low perforin content in NK cells.
Regulation (subgroup) of Gene_expression (content) of perforin in NK cells associated with rheumatoid arthritis
4) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 1.16 Pain Relevance 0.12
CD8+CD94+T cells were characterized by minimal expression of perforin, granzyme B and Foxp3.
Regulation (characterized) of Gene_expression (expression) of perforin in T cells
5) Confidence 0.10 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.07 Pain Relevance 0
The principle of the technique is based on stimulation of perforin expression by CD8+ T cells in presence of BLV proteins from a lysate of FLK-BLV cells.
Regulation (stimulation) of Gene_expression (expression) of perforin in T cells
6) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736388 Disease Relevance 0.11 Pain Relevance 0
On the other hand, Chameau et al. [105] found by quantitative PCR that corticosterone did not change the mRNA expression of the pore-forming Cav1 subunit of the L-type Ca2+ channel, and ruled out transcriptional mechanisms in the effects they observed.
Neg (not) Regulation (change) of Gene_expression (expression) of pore-forming Cav1 subunit in pore
7) Confidence 0.00 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.07 Pain Relevance 0.19

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