INT181972

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Context Info
Confidence 0.16
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.81
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Gzmb) cytoplasm (Gzmb)
Anatomy Link Frequency
T cells 4
Gzmb (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 90 91.92 High High
cytokine 17 31.60 Quite Low
Inflammation 6 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 90 91.92 High High
Disease 18 83.52 Quite High
Syndrome 6 80.36 Quite High
Macrophage Activation Syndrome 58 75.88 Quite High
Hemophagocytic Lymphohistiocytosis 44 74.56 Quite High
Chronic Myeloid Leukemia 2 74.56 Quite High
Immunization 7 68.92 Quite High
Rheumatic Diseases 10 64.36 Quite High
Congenital Anomalies 12 25.84 Quite Low
Systemic Lupus Erythematosus 4 21.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD8+CD94+T cells were characterized by minimal expression of perforin, granzyme B and Foxp3.
Regulation (characterized) of Gene_expression (expression) of granzyme B in T cells
1) Confidence 0.16 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.07 Pain Relevance 0
+), and CD8+ T cells were also assessed for perforin and granzyme B expression by flow cytometry.
Regulation (assessed) of Gene_expression (expression) of granzyme B in T cells
2) Confidence 0.10 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064882 Disease Relevance 1.40 Pain Relevance 0.31
In our study both patient groups had granzyme B expression patterns indistinguishable from those seen in healthy controls, suggesting that the observed NK dysfunction is not likely to be related to abnormal granzyme B expression.
Regulation (had) of Gene_expression (expression) of granzyme B
3) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.35 Pain Relevance 0.04

General Comments

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