INT181973

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 7.64
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (MAS1) plasma membrane (MAS1) signal transducer activity (MAS1)
Anatomy Link Frequency
macrophage 1
capsule 1
skull 1
NK cell 1
parathyroid 1
MAS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 157 98.56 Very High Very High Very High
Onset of action 2 98.34 Very High Very High Very High
addiction 4 98.12 Very High Very High Very High
Inflammation 37 93.16 High High
cytokine 37 92.64 High High
agonist 7 89.56 High High
Dopamine 6 89.20 High High
Somatostatin 6 83.76 Quite High
antagonist 8 76.08 Quite High
headache 12 70.56 Quite High
Disease Link Frequency Relevance Heat
Polyostotic Fibrous Dysplasia 118 100.00 Very High Very High Very High
Macrophage Activation Syndrome 68 100.00 Very High Very High Very High
Fibrous Dysplasia Of Bone 168 99.64 Very High Very High Very High
Disease 160 98.80 Very High Very High Very High
Rheumatoid Arthritis 158 98.56 Very High Very High Very High
Death 8 98.04 Very High Very High Very High
Syndrome 16 97.24 Very High Very High Very High
Lymphadenopathy 5 96.84 Very High Very High Very High
Hypercalcemia 12 95.44 Very High Very High Very High
Exanthema 10 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Legionella count was done by culture using the MAS-100® sampler (two air volumes were collected: 50 L and 500 L), and by culture and the FISH technique using the Impinger (air volume collected: 195 L).
Positive_regulation (using) of MAS
1) Confidence 0.49 Published 2006 Journal BMC Public Health Section Body Doc Link PMC1468404 Disease Relevance 0.59 Pain Relevance 0.07
A trans-sphenoidal approach is the preferred method in pituitary surgery, but the skull base is virtually always involved with FD in patients with MAS and GH excess, so this approach is often impossible, or difficult, at best.
Positive_regulation (excess) of MAS in skull associated with fibrous dysplasia of bone and polyostotic fibrous dysplasia
2) Confidence 0.15 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2459161 Disease Relevance 1.01 Pain Relevance 0.16
When the mutations that cause MAS were sought in parathyroid tissue, they were not present [46].
Positive_regulation (cause) of MAS in parathyroid associated with polyostotic fibrous dysplasia
3) Confidence 0.15 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2459161 Disease Relevance 1.13 Pain Relevance 0.09
The safety profile and rapid onset of action of MAS XR are similar to those of the IR tablets, but the long-acting formulation provides a persistent 12-hour therapeutic effect with once-daily dosing.57 For instance, the pharmacokinetic profile of one MAS XR 20-mg capsule is equivalent to that of two MAS IR 10-mg tablets dosed 4–6 hours apart.60
Positive_regulation (provides) of MAS XR in capsule associated with onset of action
4) Confidence 0.03 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697545 Disease Relevance 0.34 Pain Relevance 0.11
The clinical and pathologic manifestations of macrophage activation syndrome (MAS) are thought to result from the activation and uncontrolled proliferation of T-lymphocytes and well-differentiated macrophages, which leads to an unrestricted release of inflammatory cytokines, such as TNF-?
Positive_regulation (activation) of MAS in macrophage associated with inflammation, macrophage activation syndrome and cytokine
5) Confidence 0.02 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3012271 Disease Relevance 1.10 Pain Relevance 0.16
MAs are generated from the term in Equation 1 and undergo natural death at a rate proportional to their number (-?
Positive_regulation (generated) of MAs associated with death
6) Confidence 0.02 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.33 Pain Relevance 0.05
The reason for the increased incidence of MAS in patients with systemic forms of JRA in comparison with other clinical forms of this disease is not clear, but NK cell abnormalities might have a role [3].
Positive_regulation (increased) of MAS in NK cell associated with congenital anomalies, macrophage activation syndrome, rheumatoid arthritis and disease
7) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 1.79 Pain Relevance 0.30
Other groups have noted low levels of perforin expression in cytotoxic cells from patients with sJRA in comparison with other clinical forms of the disease, suggesting that this feature might be responsible for the increased incidence of MAS [26,27].
Positive_regulation (increased) of MAS associated with macrophage activation syndrome and disease
8) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 1.27 Pain Relevance 0.14

General Comments

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