INT181986

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Context Info
Confidence 0.08
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 7.40
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col7a1) cell adhesion (Col7a1) proteinaceous extracellular matrix (Col7a1)
Anatomy Link Frequency
lung 4
macrophages 3
neutrophils 1
Col7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 110 99.62 Very High Very High Very High
Inflammation 140 98.72 Very High Very High Very High
cytokine 54 91.84 High High
antagonist 41 91.04 High High
metalloproteinase 20 50.00 Quite Low
chemokine 5 38.32 Quite Low
Inflammatory response 10 17.60 Low Low
Inflammatory mediators 1 12.16 Low Low
Arthritis 6 5.00 Very Low Very Low Very Low
Sicca syndrome 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 13 100.00 Very High Very High Very High
Pulmonary Fibrosis 44 99.62 Very High Very High Very High
INFLAMMATION 144 98.72 Very High Very High Very High
Injury 65 98.22 Very High Very High Very High
Fibrosis 79 97.52 Very High Very High Very High
Myocardial Infarction 2 95.68 Very High Very High Very High
Systemic Sclerosis 134 88.88 High High
Lung Injury 11 86.88 High High
Asthma 50 86.20 High High
Cicatrix 63 85.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with PDE4 inhibitor also tended to reduce lung collagen accumulation, as was shown by total collagen assay and Masson's trichrome staining, particularly at day 14 after bleomycin administration.
Negative_regulation (reduce) of Positive_regulation (accumulation) of collagen in lung
1) Confidence 0.08 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 1.03 Pain Relevance 0.49
Babül et al. (23) have reported that EGF was administered to artificial wounds of mice, and the results showed that histamine contents were decreased and the abnormal increase of collagen could be suppressed.
Negative_regulation (suppressed) of Positive_regulation (increase) of collagen associated with injury
2) Confidence 0.04 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844601 Disease Relevance 1.30 Pain Relevance 0.35
In agreement with its central role in goblet cell differentiation treatment with anti-IL-13 almost completely abolished antigen induced GCH (vehicle, 3.9 ± 0.35 versus anti-IL-13, 0.36 ± 0.09 pix/perimeter airway, P < 0.01 )

Total lung collagen

Negative_regulation (abolished) of Positive_regulation (induced) of collagen in lung associated with hyperplasia
3) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.78 Pain Relevance 0.19
type II receptor, Wang et al [40] found that pulmonary fibrosis, including excess collagen accumulation, was greatly reduced in hamsters after bleomycin administration.
Negative_regulation (reduced) of Positive_regulation (accumulation) of collagen associated with fibrosis and pulmonary fibrosis
4) Confidence 0.02 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1177930 Disease Relevance 0.87 Pain Relevance 0.29
Moreover, in mice, targeted deletion of MMP-9 attenuated collagen accumulation, which was correlated with decreased infiltration of neutrophils and macrophages in resolving experimental myocardial infarction [34].
Negative_regulation (attenuated) of Positive_regulation (accumulation) of collagen in macrophages associated with myocardial infarction
5) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.71 Pain Relevance 0.57
Moreover, in mice, targeted deletion of MMP-9 attenuated collagen accumulation, which was correlated with decreased infiltration of neutrophils and macrophages in resolving experimental myocardial infarction [34].
Negative_regulation (attenuated) of in neutrophils Positive_regulation (accumulation) of collagen in macrophages associated with myocardial infarction
6) Confidence 0.00 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.71 Pain Relevance 0.57

General Comments

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