INT181996

Context Info Confidence 0.00 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.67 Pain Relevance 0.18

extracellular region (TNFRSF11B, TIMP1) signal transduction (TNFRSF11B) aging (TIMP1) proteinaceous extracellular matrix (TNFRSF11B) extracellular matrix organization (TNFRSF11B)

Anatomy Link Frequency osteoclast 2 TNFRSF11B (Homo sapiens) TIMP1 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 1 100.00 rheumatoid arthritis 28 89.20 cytokine 1 52.92 Inflammation 5 6.40 Leflunomide 3 5.00 methotrexate 2 5.00 Pain 1 5.00 visual analogue scale 1 5.00 Rheumatism 1 5.00

Disease Link Frequency Relevance Heat Osteoporosis 3 96.48 Rheumatoid Arthritis 28 89.20 Hypercalcemia 6 78.08 Osteoarthritis 1 64.80 Necrosis 2 59.80 Cancer 2 59.44 INFLAMMATION 5 6.40 Disease 13 5.36 Metastasis 3 5.00 Immunization 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Human osteoprotegerin inhibits cathepsin K and tartrate-resistant acid phosphatase, both osteoclast markers, but stimulates the expression of tissue inhibitor of metalloproteinases-1 [29].

osteoprotegerin Positive_regulation (stimulates) of Gene_expression (expression) of metalloproteinases-1 in osteoclast associated with metalloproteinase

1) Confidence 0.00 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 0.67 Pain Relevance 0.18

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