INT181997

Context Info Confidence 0.05 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.58 Pain Relevance 0.14

extracellular matrix organization (TNFRSF11B) cytoplasm (CTSK) signal transduction (TNFRSF11B) extracellular space (CTSK) peptidase activity (CTSK) extracellular region (TNFRSF11B)

TNFRSF11B (Homo sapiens) CTSK (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 1 77.76 rheumatoid arthritis 28 74.76 cytokine 1 59.76 Leflunomide 3 6.60 Inflammation 5 5.00 methotrexate 2 5.00 Pain 1 5.00 visual analogue scale 1 5.00 Rheumatism 1 5.00

Disease Link Frequency Relevance Heat Osteoporosis 3 98.08 Hypercalcemia 6 84.92 Rheumatoid Arthritis 28 74.76 Necrosis 2 66.64 Cancer 2 66.28 Osteoarthritis 1 40.96 Disease 13 5.00 INFLAMMATION 5 5.00 Metastasis 3 5.00 Immunization 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Wittrant and colleagues demonstrated osteoprotegerin to be an inhibitor of cathepsin K.

osteoprotegerin Negative_regulation (inhibitor) of cathepsin K

1) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 0.58 Pain Relevance 0.14

General Comments

This test has worked.